Search Results - "Arkhammar, Per"

Safety update on the use of recombinant activated factor VII in approved indications by Neufeld, Ellis J, Négrier, Claude, Arkhammar, Per, el Fegoun, Soraya Benchikh, Simonsen, Mette Duelund, Rosholm, Anders, Seremetis, Stephanie

“…Abstract This updated safety review summarises the large body of safety data available on the use of recombinant activated factor VII (rFVIIa) in approved…”
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Inhibition of insulin secretion as a new drug target in the treatment of metabolic disorders by Hansen, J Bondo, Arkhammar, Per O G, Bodvarsdottir, Thora B, Wahl, Philip

“…The pattern of insulin release is crucial for regulation of glucose and lipid haemostasis. Deficient insulin release causes hyperglycemia and diabetes, whereas…”
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Possible role of an ischemic preconditioning-like response mechanism in KATP channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function by SANDLER, Stellan, ANDERSSON, Annika K, LARSSON, Jenny, MAKEEVA, Natalia, OLSEN, Therese, ARKHAMMAR, Per O. G, HANSEN, John Bondo, ANDERS KARLSSON, F, WELSH, Nils

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New 3-Alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-Dioxide Derivatives Activate ATP-Sensitive Potassium Channels of Pancreatic Beta Cells by Nielsen, Flemming E, Ebdrup, Søren, Jensen, Anette Frost, Ynddal, Lars, Bodvarsdottir, Thora B, Stidsen, Carsten, Worsaae, Anne, Boonen, Harrie C. M, Arkhammar, Per O. G, Fremming, Tinna, Wahl, Philip, Kornø, Hanne T, Hansen, J. Bondo

“…Compound 1a (NN414) is a potent opener of Kir6.2/SUR1 K ATP channels. Compound 1a inhibits insulin release in vitro and in vivo and preserves beta cell…”
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Separation of the Glucose-Stimulated Cytoplasmic and Mitochondrial NAD(P)H Responses in Pancreatic Islet β Cells by Patterson, George H., Knobel, Susan M., Arkhammar, Per, Thastrup, Ole, Piston, David W.

“…Two-photon excitation microscopy was used to image and quantify NAD(P)H autofluorescence from intact pancreatic islets under glucose stimulation. At maximal…”
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6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-Dioxide Derivatives Potently and Selectively Activate ATP Sensitive Potassium Channels of Pancreatic β-Cells by Nielsen, Flemming E, Bodvarsdottir, Thora B, Worsaae, Anne, MacKay, Peter, Stidsen, Carsten E, Boonen, Harrie C. M, Pridal, Lone, Arkhammar, Per O. G, Wahl, Philip, Ynddal, Lars, Junager, Finn, Dragsted, Nils, Tagmose, Tina M, Mogensen, John P, Koch, Anette, Treppendahl, Svend P, Hansen, J. Bondo

“…6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives were synthesized and characterized as activators of adenosine 5‘-triphosphate…”
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Identification of Akt pathway inhibitors using redistribution screening on the FLIPR and the IN Cell 3000 analyzer by Lundholt, Betina Kerstin, Linde, Viggo, Loechel, Frosty, Pedersen, Hans-Christian, Møller, Søren, Praestegaard, Morten, Mikkelsen, Ivan, Scudder, Kurt, Bjørn, Sara Petersen, Heide, Morten, Arkhammar, Per O G, Terry, Robert, Nielsen, Søren Jensby

“…The PI3-kinase/Akt pathway is an important cell survival pathway that is deregulated in the majority of human cancers. Despite the apparent druggability of…”
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Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels by SCHOU, Søren C, HANSEN, Holger C, LEBRUN, Philippe, HANSEN, John Bondo, TAGMOSE, Tina M, BOONEN, Harrie C. M, WORSAAE, Anne, DRABOWSKI, Michael, WAHL, Philip, ARKHAMMAR, Per O. G, BODVARSDOTTIR, Thora, ANTOINE, Marie-Hélène

“…1,2,4-Thiadiazine derivatives, like 3-methyl-7-chlorobenzo-4H-1,2,4-thiadiazine 1,1-dioxide, diazoxide and 7-chloro-3-isopropylamino-4H-benzo-1,2,4-thiadiazine…”
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Possible role of an ischemic preconditioning-like response mechanism in K(ATP) channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function by Sandler, Stellan, Andersson, Annika K, Larsson, Jenny, Makeeva, Natalia, Olsen, Therese, Arkhammar, Per O G, Hansen, John Bondo, Karlsson, F Anders, Welsh, Nils

“…Potassium channel openers (KCOs) decrease insulin secretion from beta-cells. Some KCOs also protect against damage to beta-cell function and type 1 diabetes in…”
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Arylcyanoguanidines as Activators of Kir6.2/SUR1KATP Channels and Inhibitors of Insulin Release by Tagmose, Tina M, Schou, Søren C, Mogensen, John P, Nielsen, Flemming E, Arkhammar, Per O. G, Wahl, Philip, Hansen, Birgit S, Worsaae, Anne, Boonen, Harrie C. M, Antoine, Marie-Hélène, Lebrun, Philippe, Hansen, John Bondo

“…Phenylcyanoguanidines substituted with lipophilic electron-withdrawing functional groups, e.g. N-cyano-N‘-[3,5-bis-(trifluoromethyl)phenyl]-N‘…”
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Dihydroxyacetone-induced Oscillations in Cytoplasmic Free Ca2+ and the ATP/ADP Ratio in Pancreatic β-Cells at Substimulatory Glucose by Juntti-Berggren, Lisa, Webb, Dominic-Luc, Arkhammar, Per O.G., Schultz, Vera, Schweda, Elke K.H., Tornheim, Keith, Berggren, Per-Olof

“…Glucose stimulation of pancreatic β-cells causes oscillatory influx of Ca2+, leading to pulsatile insulin secretion. We have proposed that this is due to…”
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Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca2+ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K+ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets by MAEDLER, Kathrin, STØRLING, Joachim, STURIS, Jeppe, ZUELLIG, Richard A, SPINAS, Giatgen A, ARKHAMMAR, Per O. G, MANDRUP-POULSEN, Thomas, DONATH, Marc Y

“…Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca 2+ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a…”
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2-(4-methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 KATP channels by NIELSEN, Flemming E, JACOBSEN, Palle, WORSAAE, Anne, ARKHAMMAR, Per O. G, WAHL, Philip, HANSEN, John Bondo

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Su1794 TOLERABILITY, SAFETY, AND CLINICAL PHARMACOLOGY OF AZD7798, A DEPLETING ANTIBODY TARGETING CCR9 by Harper, Andrew R., Bouma, Gerben, Lundahl, Anna, Larsson, Julia, Bock, David, Eck, Steven, Duncan, Marnie, Nys, Josquin, Mo, John, Gehrmann, Ulf, Arkhammar, Per, Kiraga, Joanna, Popinska, Agnieszka, Soto, Pablo Forte, Belvisi, Maria G., Fowler, Andrew, Marks, Daniel J.

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Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells by Tagmose, Tina M, Mogensen, John P, Agerholm, Pia C, Arkhammar, Per O.G, Wahl, Philip, Worsaae, Anne, Hansen, J.Bondo

“…3,5-Disubstituted-phenylcyanoguanidines have been identified as activators of SUR1/Kir6.2 potassium channels and as potent inhibitors of insulin release from…”
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Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release by Tagmose, Tina M, Schou, Søren C, Mogensen, John P, Nielsen, Flemming E, Arkhammar, Per O G, Wahl, Philip, Hansen, Birgit S, Worsaae, Anne, Boonen, Harrie C M, Antoine, Marie-Hélène, Lebrun, Philippe, Hansen, John Bondo

“…Phenylcyanoguanidines substituted with lipophilic electron-withdrawing functional groups, e.g. N-cyano-N'-[3,5-bis-(trifluoromethyl)phenyl]-N'…”
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Activation by adrenaline of a low-conductance G protein-dependent K + channel in mouse pancreatic B cells by Rorsman, Patrik, Bokvist, Krister, Ämmälä, Carina, Arkhammar, Per, Berggren, Per-Olof, Larsson, Olof, Wåhlander, Karin

“…Insulin is produced and secreted by the B cells in the endocrine pancreas. In vivo, insulin secretion is under the control of a number of metabolic, neural and…”
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Recombinant activated factor VII in the treatment of bleeds and for the prevention of surgery-related bleeding in congenital haemophilia with inhibitors by Santagostino, Elena, Escobar, Miguel, Ozelo, Margareth, Solimeno, Luigi, Arkhammar, Per, Lee, Hye Youn, Rosu, Gabriela, Giangrande, Paul

“…Abstract The availability of recombinant activated factor VII (rFVIIa, eptacog alfa activated) has greatly advanced the care of patients with haemophilia A or…”
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Long-Term Safety of Roflumilast in Patients with Chronic Obstructive Pulmonary Disease , a Multinational Observational Database Cohort by Garbe, Edeltraut, Hoti, Fabian, Schink, Tania, Svendsen, Kristian, Al-Eid, Haydar, Arkhammar, Per, Carlholm, Marie, Fjallbrant, Harald, Franzén, Stefan, Hedlund, Cecilia, Kollhorst, Bianca, Kumar, Atul, Lobier, Muriel, Mushnikov, Vasili, Persson, Tore, Qiao, Xu, Salosensaari, Aaro, Schaefer, Wiebke, Sicignano, Nicholas M., Johansson, Gunnar, Dareng, Eileen O.

“…Purpose: This study evaluated the long-term safety of roflumilast in patients with chronic obstructive pulmonary disease or chronic bronchitis using electronic…”
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Long-Term Safety of Roflumilast in Patients with Chronic Obstructive Pulmonary Disease, a Multinational Observational Database Cohort Study by Garbe, Edeltraut, Hoti, Fabian, Schink, Tania, Svendsen, Kristian, Al-Eid, Haydar, Arkhammar, Per, Carlholm, Marie, Fjällbrant, Harald, Franzén, Stefan, Hedlund, Cecilia, Kollhorst, Bianca, Kumar, Atul, Lobier, Muriel, Mushnikov, Vasili, Persson, Tore, Qiao, Xu, Salosensaari, Aaro, Schäfer, Wiebke, Sicignano, Nicholas M, Johansson, Gunnar, Dareng, Eileen O

“…This study evaluated the long-term safety of roflumilast in patients with chronic obstructive pulmonary disease or chronic bronchitis using electronic…”
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