Search Results - "Arjun Surya"

The discovery of potent small molecule activators of human STING by Pryde, David C., Middya, Sandip, Banerjee, Monali, Shrivastava, Ritesh, Basu, Sourav, Ghosh, Rajib, Yadav, Dharmendra B., Surya, Arjun

“…The adaptor protein STING plays a major role in innate immune sensing of cytosolic nucleic acids, by triggering a robust interferon response. Despite the…”
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G10 is a direct activator of human STING by Banerjee, Monali, Middya, Sandip, Shrivastava, Ritesh, Basu, Sourav, Ghosh, Rajib, Pryde, David C, Yadav, Dharmendra B, Surya, Arjun

“…The cGAS/STING pathway initiates an innate immune response when DNA is detected in the cytosol. DNA bound cGAS synthesizes cyclic dinucleotides which bind and…”
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782-D Systemic delivery of novel, allosteric STING agonist CRD3874-SI leads to robust anti-cancer activity by generating pro-inflammatory Type I IFN signals while blocking proton channel mediated toxicity by Banerjee, Monali, Middya, Sandip, Shrivastava, Ritesh, Middya, Anindita, Mane, Nagaswamy, Rawat, Nidhi, Soram, Thanilsana, Chakraborty, Debjani, Ghosh, Rajib, Mansuri, Rubeena Rais, Yadav, Dharmendra, Gautam, Anuj, Singh, Anuj, Puniya, Kavita, Pryde, David, Basu, Sourav, Sonego, Fabiane, Martin, Gaelle, Martin-Jeantet, Perrine, Pappalardo, Angela, Thiam, Kader, Kelly, Ciara, Surya, Arjun

“…BackgroundSTING activates Type1 interferon and pro-inflammatory responses to drive anti-tumor immunity. Current STING agonists under clinical investigation…”
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Transducin Activation by the Bovine Opsin Apoprotein (∗) by Surya, Arjun, Foster, Kenneth W., Knox, Barry E.

“…The interaction of the bovine opsin apoprotein with transducin in rod outer segment membranes was investigated using a guanyl nucleotide exchange assay. In…”
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Molecular cloning and pharmacological characterization of bovine calcitonin receptor-like receptor from bovine aortic endothelial cells by Aiyar, Nambi, Disa, Jyoti, Ao, Zhaohui, Xu, Dong, Surya, Arjun, Pillarisetti, Kodandaram, Parameswaran, Narayanan, Gupta, Shalley K, Douglas, Stephen A, Nambi, Ponnal

“…A complementary DNA encoding calcitonin receptor-like receptor (CRLR) was isolated from a bovine aortic endothelial cell library. The bovine CRLR has 462 amino…”
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The discovery of potent small molecule cyclic urea activators of STING by Basu, Sourav, Middya, Sandip, Banerjee, Monali, Ghosh, Rajib, Pryde, David C., Yadav, Dharmendra B., Shrivastava, Ritesh, Surya, Arjun

“…STING mediates innate immune responses that are triggered by the presence of cytosolic DNA. Activation of STING to boost antigen recognition is a therapeutic…”
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Modulation of Opsin Apoprotein Activity by Retinal by Surya, Arjun, Knox, Barry E.

“…The bovine opsin apoprotein activates transducin, although at a much reduced level than light-activated rhodopsin (Surya, A., Foster, K., and Knox, B. (1995)…”
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Light-dependent Activation of Rod Transducin by Pineal Opsin by Max, Marianna, Surya, Arjun, Takahashi, Joseph S., Margolskee, Robert F., Knox, Barry E.

“…The pineal gland expresses a unique member of the opsin family (P-opsin; Max, M., McKinnon, P. J., Seidenman, K. J., Barrett, R. K., Applebury, M. L.,…”
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Enhancement of Opsin Activity by all-trans-retinal by SURYA, ARJUN, KNOX, BARRY E.

“…The rod cell photoreceptor apoprotein, opsin, activates the G-protein, transducin, although at a much reduced level than light-activated rhodopsin. The ability…”
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Abstract 5322: Discovery of CRD1601, a potent and selective HPK1 inhibitor with robust in vivo anti-cancer activity by Banerjee, Monali, Shrivastava, Ritesh, Pryde, David, Middya, Sandip, Debnath, Sabyasachi, Middya, Anindita, Yadav, Dharmendra, Rawat, Nidhi, Ghosh, Rajib, Padaliya, Manisha, Basu, Sourav, Surya, Arjun

“…Background: Haematopoietic Progenitor Kinase (HPK-1, MAP4K1) is a member of the STE20 family of serine/threonine kinases, expressed predominantly in…”
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Abstract LB-061: CRD5500: A versatile small molecule STING agonist amenable to bioconjugation as an ADC by Banerjee, Monali, Basu, Sourav, Middya, Sandip, Shrivastava, Ritesh, Ghosh, Rajib, Pryde, David C., Yadav, Dharmendra, Bhattacharya, Gopal, Soram, Thanilsana, Puniya, Kavita, Raina, Ritika, Kadam, Vijay, Garai, Sujay, Sharma, Priti, Singh, Anuj, Shinde, Vaibhav, Rawat, Nidhi, Middya, Anindita, Sinha, Arghyotri, Chandel, Sunita, Narisipuram, Ganesh, Chatterjee, Abhisek, Mane, Nagaswamy, Surya, Arjun

“…BACKGROUND Innate immune signaling mediated through STING (Stimulator of Interferon Genes) generates a Type I interferon (Type 1 IFN) signal that increases T…”
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Abstract 3510: Small molecule ACSS2 inhibitors target acetate metabolizing tumor cells in hypoxic conditions by Banerjee, Monali, Basu, Sourav, Chakraborty, Debjani, Shrivastava, Ritesh, Middya, Sandip, Ghosh, Rajib, Yadav, Dharmendra, Sinha, Arghyotri, Das, Avratanu, Pandit, Navin, Naiya, Mohinder, Debnath, Sabyasachi, Dey, Sangeeta, Dasgupta, Debottam, Das, Nirmal, Singh, Anuj, Sarkar, Dipayan, Sarkar, Sukanya, Narasipuram, Ganesh, Mane, Nagaswami, Singhal, Nicky, Rawat, Nidhi, Middya, Anindita, Surya, Arjun

“…BACKGROUND Tumors such as glioblastoma proliferating under hypoxic, hypoglycemic and hypolipidemic conditions derive almost half of their nutritional…”
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Temozolomide analogs with improved brain/plasma ratios – Exploring the possibility of enhancing the therapeutic index of temozolomide by Rai, Roopa, Banerjee, Monali, Wong, Darren H., McCullagh, Emma, Gupta, Ashu, Tripathi, Shailendra, Riquelme, Eduardo, Jangir, Ramnivas, Yadav, Shyamraj, Raja, Mohd, Melkani, Pankaj, Dixit, Vikas, Patil, Umesh, Shrivastava, Ritesh, Middya, Sandip, Olivares, Felipe, Guerrero, Javier, Surya, Arjun, Pham, Son M., Bernales, Sebastián, Protter, Andrew A., Hung, David T., Chakravarty, Sarvajit

“…[Display omitted] Temozolomide is a chemotherapeutic agent that is used in the treatment of glioblastoma and other malignant gliomas. It acts through DNA…”
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Abstract 7481: The allosteric STING agonist CRD3874 is systemically tolerated demonstrates systemic tolerability by Banerjee, Monali, Middya, Sandip, Shrivastava, Ritesh, Middya, Anindita, Mane, Nagaswamy, Rawat, Nidhi, Soram, Thanilsana, Chakraborty, Debjani, Ghosh, Rajib, Mansuri, Rubeena R., Yadav, Dharmendra, Gautam, Anuj, Singh, Anuj, Puniya, Kavita, Pryde, David, Basu, Sourav, Sonego, Fabiane, Martin, Gaelle H., Thiam, Kader, Surya, Arjun

“…Background: The activation of STING by CDN bind site targeting ligands leads to the generation of Type I interferons as well as pyroptosis and autophagy of the…”
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Abstract 1996: Intravenous administration of the small molecule STING agonist CRD5500 elicits potent anti-tumor immune responses in cold tumors by Banerjee, Monali, Basu, Sourav, Middya, Sandip, Shrivastava, Ritesh, Middya, Anindita, Ghosh, Rajib, Mansuri, Rubeena R., Mane, Nagaswamy, Soram, Thanilsana, Yadav, Dharmendra, Chakraborty, Debjani, Singh, Anuj, Pryde, David C., Puniya, Kavita, Rawat, Nidhi, Surya, Arjun

“…Background: Innate immune signaling mediated through STING (Stimulator of Interferon Genes) generates a Type I interferon (Type 1 IFN) signal that increases T…”
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Abstract 2122: CRD1600 is a potent HPK-I inhibitor with robust immune modulatory properties by Shrivastava, Ritesh, Pryde, David C., Yadav, Dharmendra, Chatterjee, Abhisek, Middya, Sandip, Shaikh, Sameer, Ghosh, Rajib, Debnath, Sabyasachi, Mane, Nagaswamy, Middya, Anindita, Rawat, Nidhi, Gautam, Anuj, Basu, Sourav, Banerjee, Monali, Surya, Arjun

“…Background: Haematopoietic Progenitor Kinase (HPK-1, MAP4K1) is a member of the STE20 family of serine/threonine kinases, expressed predominantly in…”
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G10 is a direct activator of human STING by Monali Banerjee, Sandip Middya, Ritesh Shrivastava, Sourav Basu, Rajib Ghosh, David C. Pryde, Dharmendra B. Yadav, Arjun Surya, Michael Nevels

“…The cGAS/STING pathway initiates an innate immune response when DNA is detected in the cytosol. DNA bound cGAS synthesizes cyclic dinucleotides which bind and…”
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Abstract LB-085: RG70099: A novel, highly potent dual IDO1/TDO inhibitor to reverse metabolic suppression of immune cells in the tumor micro-environment by Gyulveszi, Gabor, Fischer, Christine, Mirolo, Massimiliano, Stern, Martin, Green, Luke, Ceppi, Maurizio, Wang, Haiyan, Bürgi, Beatrice, Staempfli, Andreas, Muster, Wolfgang, van Waterschoot, Robert, Gloge, Andreas, Sade, Hadassah, Klaman, Irina, Hoelzlvimmer, Gabriele, Surya, Arjun, Banerjee, Monali, Shrivastava, Ritesh, Middya, Sandip, Yadav, Dharmendra, Basu, Sourav, Acuna, Gonzalo

“…IDO1/TDO* mediate substantial immunosuppressive effects through the metabolism of tryptophan (Trp) to kynurenine (Kyn). The consequent decrease in Trp…”
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Abstract LB-085: RG70099: A novel, highly potent dual IDO1TDO inhibitor to reverse metabolic suppression of immune cells in the tumor micro-environment by Gyulveszi, Gabor, Fischer, Christine, Mirolo, Massimiliano, Stern, Martin, Green, Luke, Ceppi, Maurizio, Wang, Haiyan, Brgi, Beatrice, Staempfli, Andreas, Muster, Wolfgang, van Waterschoot, Robert, Gloge, Andreas, Sade, Hadassah, Klaman, Irina, Hoelzlvimmer, Gabriele, Surya, Arjun, Banerjee, Monali, Shrivastava, Ritesh, Middya, Sandip, Yadav, Dharmendra, Basu, Sourav, Acuna, Gonzalo

“…IDO1TDO mediate substantial immunosuppressive effects through the metabolism of tryptophan (Trp) to kynurenine (Kyn). The consequent decrease in Trp suppresses…”
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Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kδ by Pujala, Brahmam, Agarwal, Anil K, Middya, Sandip, Banerjee, Monali, Surya, Arjun, Nayak, Anjan K, Gupta, Ashu, Khare, Sweta, Guguloth, Rambabu, Randive, Nitin A, Shinde, Bharat U, Thakur, Anamika, Patel, Dhananjay I, Raja, Mohd, Green, Michael J, Alfaro, Jennifer, Avila, Patricio, Pérez de Arce, Felipe, Almirez, Ramona G, Kanno, Stacy, Bernales, Sebastián, Hung, David T, Chakravarty, Sarvajit, McCullagh, Emma, Quinn, Kevin P, Rai, Roopa, Pham, Son M

“…The aberrant activation of B-cells has been implicated in several types of cancers and hematological disorders. BTK and PI3Kδ are kinases responsible for…”
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