Search Results - "Arjan, van Caam P M"

Fibroblast Activation Protein Targeted Photodynamic Therapy Selectively Kills Activated Skin Fibroblasts from Systemic Sclerosis Patients and Prevents Tissue Contraction by Dorst, Daphne N, van Caam, Arjan P M, Vitters, Elly L, Walgreen, Birgitte, Helsen, Monique M A, Klein, Christian, Gudi, Shreya, Wubs, Tirza, Kumari, Jyoti, Vonk, Madelon C, van der Kraan, Peter M, Koenders, Marije I

“…Systemic sclerosis (SSc) is a rare, severe, auto-immune disease characterized by inflammation, vasculopathy and fibrosis. Activated (myo)fibroblasts are…”
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Identification of Transcription Factors Responsible for a Transforming Growth Factor-β-Driven Hypertrophy-like Phenotype in Human Osteoarthritic Chondrocytes by Thielen, Nathalie G M, Neefjes, Margot, Vitters, Elly L, van Beuningen, Henk M, Blom, Arjen B, Koenders, Marije I, van Lent, Peter L E M, van de Loo, Fons A J, Blaney Davidson, Esmeralda N, van Caam, Arjan P M, van der Kraan, Peter M

“…During osteoarthritis (OA), hypertrophy-like chondrocytes contribute to the disease process. TGF-β's signaling pathways can contribute to a hypertrophy(-like)…”
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Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-β by Pieters, Bartijn C H, Arntz, Onno J, Bennink, Miranda B, Broeren, Mathijs G A, van Caam, Arjan P M, Koenders, Marije I, van Lent, Peter L E M, van den Berg, Wim B, de Vries, Marieke, van der Kraan, Peter M, van de Loo, Fons A J

“…Extracellular vesicles, including exosomes, have been identified in all biological fluids and rediscovered as an important part of the intercellular…”
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Transcription Factors in Cartilage Homeostasis and Osteoarthritis by Neefjes, Margot, Caam, Arjan P.M. van, Kraan, Peter M. van der

“…Osteoarthritis (OA) is the most common degenerative joint disease, and it is characterized by articular cartilage loss. In part, OA is caused by aberrant…”
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TGFβ/BMP Signaling Pathway in Cartilage Homeostasis by Thielen, Nathalie G M, van der Kraan, Peter M, van Caam, Arjan P M

“…Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate extracellular matrix production and degradation. In turn, chondrocyte…”
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Systemic sclerosis-associated pulmonary arterial hypertension is characterized by a distinct peripheral T helper cell profile by Papadimitriou, Theodoros Ioannis, Lemmers, Jacqueline M J, van Caam, Arjan P M, Vos, Jacqueline L, Vitters, Elly L, Stinissen, Lizan, van Leuven, Sander I, Koenders, Marije I, van der Kraan, P M, Koenen, Hans J P M, Smeets, Ruben L, Nijveldt, Robin, Vonk, Madelon C, Thurlings, Rogier M

“…Systemic sclerosis (SSc) is characterized by multiple clinical manifestations. Vasculopathy is a main disease hallmark and ranges in severity from an…”
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Separating friend from foe: Inhibition of TGF-β-induced detrimental SMAD1/5/9 phosphorylation while maintaining protective SMAD2/3 signaling in OA chondrocytes by Thielen, Nathalie G.M., van Caam, Arjan P.M., v. Beuningen, Henk M., Vitters, Elly L., van den Bosch, Martijn H.J., Koenders, Marije I., van de Loo, Fons A.J., Blaney Davidson, Esmeralda N., van der Kraan, Peter M.

“…Transforming growth factor-β (TGF-β) signaling via SMAD2/3 is crucial to control cartilage homeostasis. However, TGF-β can also have detrimental effects by…”
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Prediction of the Effect of the Osteoarthritic Joint Microenvironment on Cartilage Repair by Neefjes, Margot, Housmans, Bas A C, van Beuningen, Henk M, Vitters, Elly L, van den Akker, Guus G H, Welting, Tim J M, van Caam, Arjan P M, van der Kraan, Peter M

“…Osteoarthritis (OA) is characterized by progressive articular cartilage loss. Human mesenchymal stromal cells (MSCs) can be used for cartilage repair therapies…”
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An Improved Diagnostic Tool to Predict Cartilage Formation in an Osteoarthritic Joint Environment by Margot, Neefjes, Bas, Housmans A C, Nathalie, Thielen G M, Henk, van Beuningen M, Elly, Vitters L, Guus, van den Akker G H, Tim, Welting J M, Arjan, van Caam P M, Peter, van der Kraan M

“…Osteoarthritis (OA) is characterized by progressive articular cartilage loss. Due to the chondrogenic potential of human mesenchymal stromal cells (MSCs),…”
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Reduced Euchromatin histone methyltransferase 1 causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice by Balemans, Monique C.M., Ansar, Muhammad, Oudakker, Astrid R., van Caam, Arjan P.M., Bakker, Brenda, Vitters, Elly L., van der Kraan, Peter M., de Bruijn, Diederik R.H., Janssen, Sanne M., Kuipers, Arthur J., Huibers, Manon M.H., Maliepaard, Eliza M., Walboomers, X. Frank, Benevento, Marco, Nadif Kasri, Nael, Kleefstra, Tjitske, Zhou, Huiqing, Van der Zee, Catharina E.E.M., van Bokhoven, Hans

“…Haploinsufficiency of Euchromatin histone methyltransferase 1 (EHMT1), a chromatin modifying enzyme, is the cause of Kleefstra syndrome (KS). KS is an…”
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IL37 dampens the IL1β-induced catabolic status of human OA chondrocytes by van Geffen, Ellen W, van Caam, Arjan P M, van Beuningen, Henk M, Vitters, Elly L, Schreurs, Wim, van de Loo, Fons A, van Lent, Peter L E M, Koenders, Marije I, Blaney Davidson, Esmeralda N, van der Kraan, Peter M

“…A crucial feature of OA is cartilage degradation. This process is mediated by pro-inflammatory cytokines, among other factors, via induction of…”
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Nailfold capillaroscopy and candidate-biomarker levels in systemic sclerosis-associated pulmonary hypertension: A cross-sectional study by Lemmers, Jacqueline MJ, van Caam, Arjan PM, Kersten, Brigit, van den Ende, Cornelia HM, Knaapen, Hanneke, van Dijk, Arie PJ, Hagmolen of ten Have, Wanda, van den Hoogen, Frank HJ, Koenen, Hans, van Leuven, Sander I, Alkema, Wynand, Smeets, Ruben L, Vonk, Madelon C

“…Objectives: Pulmonary hypertension is one of the leading causes of death in systemic sclerosis. Early detection and treatment of pulmonary hypertension in…”
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Cell-integrated serum-induced signalling patterns can differentiate between hand and knee osteoarthritis patients by Neefjes, Margot, Housmans, Bas A C, Kaffa, Charlotte, Thielen, Nathalie G M, Joosten, Leo A B, van den Ende, Cornelia H M, Vitters, Elly L, van den Akker, Guus G H, Welting, Tim J M, van Caam, Arjan P M, van der Kraan, Peter M

“…Abstract Objective OA is a very heterogeneous disease. Here, we aimed to differentiate OA patients based on their serum-induced cell-integrated signalling…”
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A Novel In Vitro Disease Model for Systemic Sclerosis Using Polyisocyanide Hydrogels by Kumari, Jyoti, Wubs, Tirza, Caam, Arjan P.M., Dorst, Daphne N., Wagener, Frank A. D. T. G., Kouwer, Paul H. J.

“…Systemic sclerosis (SSc) is a rare autoimmune disease with limited treatment options that is characterized by fibrosis in various organs. To screen the…”
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Growth factors that drive aggrecan synthesis in healthy articular cartilage. Role for transforming growth factor-β? by van der Kraan, Peter M., van Caam, Arjan P.M., Blaney Davidson, Esmeralda N., van den Bosch, Martijn H.J., van de Loo, Fons A.J.

“…Articular cartilage makes smooth movement possible and destruction of this tissue leads to loss of joint function. An important biomolecule that determines…”
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Commercial Cow Milk Contains Physically Stable Extracellular Vesicles Expressing Immunoregulatory TGF-[beta] by Pieters, Bartijn C. H, Arntz, Onno J, Bennink, Miranda B, Broeren, Mathijs G. A, van Caam, Arjan P. M, Koenders, Marije I, van Lent, Peter L. E. M, van den Berg, Wim B, de Vries, Marieke, van der Kraan, Peter M, van de Loo, Fons A. J

“…Scope Extracellular vesicles, including exosomes, have been identified in all biological fluids and rediscovered as an important part of the intercellular…”
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