Search Results - "Aristotelous, Tonia"

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor by Aristotelous, Tonia, Ahn, Seungkirl, Shukla, Arun K, Gawron, Sylwia, Sassano, Maria F, Kahsai, Alem W, Wingler, Laura M, Zhu, Xiao, Tripathi-Shukla, Prachi, Huang, Xi-Ping, Riley, Jennifer, Besnard, Jérémy, Read, Kevin D, Roth, Bryan L, Gilbert, Ian H, Hopkins, Andrew L, Lefkowitz, Robert J, Navratilova, Iva

“…G-protein coupled receptors (GPCRs) are the primary target class of currently marketed drugs, accounting for about a quarter of all drug targets of approved…”
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Surface plasmon resonance analysis of seven-transmembrane receptors by Aristotelous, Tonia, Hopkins, Andrew L, Navratilova, Iva

“…G-protein coupled receptors (GPCRs) are the primary target class of currently marketed drugs, accounting for around a third of all drug targets of approved…”
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A mutant O-GlcNAcase enriches Drosophila developmental regulators by Selvan, Nithya, Williamson, Ritchie, Mariappa, Daniel, Campbell, David G, Gourlay, Robert, Ferenbach, Andrew T, Aristotelous, Tonia, Hopkins-Navratilova, Iva, Trost, Matthias, van Aalten, Daan M F

“…An inactive mutant of a bacterial O-GlcNAc hydrolase was used as an affinity reagent to enrich O -GlcNAc-modified proteins from Drosophila embryos and led to…”
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Surveying GPCR solubilisation conditions using surface plasmon resonance by Navratilova, Iva Hopkins, Aristotelous, Tonia, Bird, Louise E., Hopkins, Andrew L.

“…Biophysical screening techniques, such as surface plasmon resonance, enable detailed kinetic analysis of ligands binding to solubilised G-protein coupled…”
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O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis by Schimpl, Marianne, Zheng, Xiaowei, Borodkin, Vladimir S, Blair, David E, Ferenbach, Andrew T, Schüttelkopf, Alexander W, Navratilova, Iva, Aristotelous, Tonia, Albarbarawi, Osama, Robinson, David A, Macnaughtan, Megan A, van Aalten, Daan M F

“…OGT modifies numerous proteins with O -GlcNAc, but the mechanism for this reaction has been difficult to define. Ternary crystal structures and activity assays…”
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A biophysical approach for the study of g-protein coupled receptor complexes by Aristotelous, Tonia

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Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening by Navratilova, Iva, Aristotelous, Tonia, Picaud, Sarah, Chaikuad, Apirat, Knapp, Stefan, Filappakopoulos, Panagis, Hopkins, Andrew L

“…The discovery of novel bromodomain inhibitors by fragment screening is complicated by the presence of dimethyl sulfoxide (DMSO), an acetyl-lysine mimetic, that…”
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O‑GlcNAcase Fragment Discovery with Fluorescence Polarimetry by Borodkin, Vladimir S, Rafie, Karim, Selvan, Nithya, Aristotelous, Tonia, Navratilova, Iva, Ferenbach, Andrew T, van Aalten, Daan M. F

“…The attachment of the sugar N-acetyl-D-glucosamine (GlcNAc) to specific serine and threonine residues on proteins is referred to as protein O-GlcNAcylation…”
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A Novel Allosteric Inhibitor of the Uridine Diphosphate N‑Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei by Urbaniak, Michael D, Collie, Iain T, Fang, Wenxia, Aristotelous, Tonia, Eskilsson, Susanne, Raimi, Olawale G, Harrison, Justin, Navratilova, Iva Hopkins, Frearson, Julie A, van Aalten, Daan M. F, Ferguson, Michael A. J

“…Uridine diphosphate N-acetylglucosamine pyrophosphorylase (UAP) catalyzes the final reaction in the biosynthesis of UDP-GlcNAc, an essential metabolite in many…”
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