Search Results - "Aristizabal, Maria J"

Biological embedding of experience: A primer on epigenetics by Aristizabal, Maria J., Anreiter, Ina, Halldorsdottir, Thorhildur, Odgers, Candice L., McDade, Thomas W., Goldenberg, Anna, Mostafavi, Sara, Kobor, Michael S., Binder, Elisabeth B., Sokolowski, Marla B., O’Donnell, Kieran J.

“…Biological embedding occurs when life experience alters biological processes to affect later life health and well-being. Although extensive correlative data…”
Get full text

Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip by Chan, Yujia A, Aristizabal, Maria J, Lu, Phoebe Y T, Luo, Zongli, Hamza, Akil, Kobor, Michael S, Stirling, Peter C, Hieter, Philip

“…DNA:RNA hybrid formation is emerging as a significant cause of genome instability in biological systems ranging from bacteria to mammals. Here we describe the…”
Get full text

R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants by Stirling, Peter C, Chan, Yujia A, Minaker, Sean W, Aristizabal, Maria J, Barrett, Irene, Sipahimalani, Payal, Kobor, Michael S, Hieter, Philip

“…Genome instability via RNA:DNA hybrid-mediated R loops has been observed in mutants involved in various aspects of transcription and RNA processing. The…”
Get full text

RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability by Chang, Emily Yun-Chia, Novoa, Carolina A, Aristizabal, Maria J, Coulombe, Yan, Segovia, Romulo, Chaturvedi, Richa, Shen, Yaoqing, Keong, Christelle, Tam, Annie S, Jones, Steven J M, Masson, Jean-Yves, Kobor, Michael S, Stirling, Peter C

“…Sgs1, the orthologue of human Bloom's syndrome helicase BLM, is a yeast DNA helicase functioning in DNA replication and repair. We show that loss increases…”
Get full text

Autosomal sex-associated co-methylated regions predict biological sex from DNA methylation by Gatev, Evan, Inkster, Amy M, Negri, Gian Luca, Konwar, Chaini, Lussier, Alexandre A, Skakkebaek, Anne, Sokolowski, Marla B, Gravholt, Claus H, Dunn, Erin C, Kobor, Michael S, Aristizabal, Maria J

“…Abstract Sex is a modulator of health that has been historically overlooked in biomedical research. Recognizing this knowledge gap, funding agencies now…”
Get full text

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts by Chang, Emily Yun-Chia, Tsai, Shuhe, Aristizabal, Maria J., Wells, James P., Coulombe, Yan, Busatto, Franciele F., Chan, Yujia A., Kumar, Arun, Dan Zhu, Yi, Wang, Alan Ying-Hsu, Fournier, Louis-Alexandre, Hieter, Philip, Kobor, Michael S., Masson, Jean-Yves, Stirling, Peter C.

“…Ectopic R-loop accumulation causes DNA replication stress and genome instability. To avoid these outcomes, cells possess a range of anti-R-loop mechanisms,…”
Get full text

An important role for triglyceride in regulating spermatogenesis by Chao, Charlotte F, Pesch, Yanina-Yasmin, Yu, Huaxu, Wang, Chenjingyi, Aristizabal, Maria J, Huan, Tao, Tanentzapf, Guy, Rideout, Elizabeth

“…is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called…”
Get full text

Risk-focused differences in molecular processes implicated in SARS-CoV-2 infection: corollaries in DNA methylation and gene expression by Konwar, Chaini, Asiimwe, Rebecca, Inkster, Amy M, Merrill, Sarah M, Negri, Gian L, Aristizabal, Maria J, Rider, Christopher F, MacIsaac, Julie L, Carlsten, Christopher, Kobor, Michael S

“…Understanding the molecular basis of susceptibility factors to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health…”
Get full text

The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition by Aristizabal, Maria J, Negri, Gian Luca, Kobor, Michael S

“…RNA polymerase II (RNAPII) contains a unique C-terminal domain that is composed of heptapeptide repeats and which plays important regulatory roles during gene…”
Get full text

Key Functional Regions in the Histone Variant H2A.Z C-Terminal Docking Domain by Wang, Alice Y., Aristizabal, Maria J., Ryan, Colm, Krogan, Nevan J., Kobor, Michael S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8 by Aristizabal, Maria J, Negri, Gian Luca, Benschop, Joris J, Holstege, Frank C P, Krogan, Nevan J, Kobor, Michael S

“…The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is composed of heptapeptide repeats, which play a key regulatory role in gene expression. Using…”
Get full text

Rapid cold hardening modifies ion regulation to delay anoxia-induced spreading depolarization in the CNS of the locust by Srithiphaphirom, Phinyaphat, Wang, Yuyang, Aristizabal, Maria J., Robertson, R. Meldrum

“…Insects experience different kinds of environmental stresses that can impair neural performance, leading to spreading depolarization (SD) of nerve cells and…”
Get full text

Leveraging Gene Redundancy to Find New Histone Drivers in Cancer by Ostroverkhova, Daria, Espiritu, Daniel, Aristizabal, Maria J, Panchenko, Anna R

“…Histones play a critical role in chromatin function but are susceptible to mutagenesis. In fact, numerous mutations have been observed in several cancer types,…”
Get full text

Predominant DNMT and TET mediate effects of allergen on the human bronchial epithelium in a controlled air pollution exposure study by Li, Hang, Ryu, Min Hyung, Rider, Christopher F., Tse, Wayne, Clifford, Rachel L., Aristizabal, Maria J., Wen, Weiping, Carlsten, Chris

“…Epidemiological data show that traffic-related air pollution contributes to the increasing prevalence and severity of asthma. DNA methylation (DNAm) changes…”
Get full text

Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast by Aristizabal, Maria J., Dever, Kristy, Negri, Gian Luca, Shen, Mary, Hawe, Nicole, Benschop, Joris J., Holstege, Frank C.P., Krogan, Nevan J., Sadowski, Ivan, Kobor, Michael S.

“…Fcp1 is a protein phosphatase that facilitates transcription elongation and termination by dephosphorylating the C-terminal domain of RNA polymerase II…”
Get full text

A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans by Lu, Phoebe Y T, Kirlin, Alyssa C, Aristizabal, Maria J, Brewis, Hilary T, Lévesque, Nancy, Setiaputra, Dheva T, Avvakumov, Nikita, Benschop, Joris J, Groot Koerkamp, Marian, Holstege, Frank C P, Krogan, Nevan J, Yip, Calvin K, Côté, Jacques, Kobor, Michael S

“…Abstract The NuA4 lysine acetyltransferase complex acetylates histone and nonhistone proteins and functions in transcription regulation, cell cycle…”
Get full text

Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome by Steunou, Anne-Lise, Cramet, Myriam, Rossetto, Dorine, Aristizabal, Maria J., Lacoste, Nicolas, Drouin, Simon, Côté, Valérie, Paquet, Eric, Utley, Rhea T., Krogan, Nevan, Robert, François, Kobor, Michael S., Côté, Jacques

“…Recognition of histone marks by reader modules is thought to be at the heart of epigenetic mechanisms. These protein domains are considered to function by…”
Get full text

Low Glycolysis Is Neuroprotective during Anoxic Spreading Depolarization (SD) and Reoxygenation in Locusts by Wang (王宇扬), Yuyang, Little, Alexander G., Aristizabal, Maria J., Robertson, R. Meldrum

“…Abstract Migratory locusts enter a reversible hypometabolic coma to survive environmental anoxia, wherein the cessation of CNS activity is driven by spreading…”
Get full text

A single flexible RNAPII-CTD integrates many different transcriptional programs by Aristizabal, Maria J., Kobor, Michael S.

“…The RNAPII-CTD functions as a binding platform for coordinating the recruitment of transcription associated factors. Altering CTD function results in gene…”
Get full text

Conditional genetic interactions of RTT107, SLX4, and HRQ1 reveal dynamic networks upon DNA damage in S. cerevisiae by Leung, Grace P, Aristizabal, Maria J, Krogan, Nevan J, Kobor, Michael S

“…The DNA damage response (DDR) is a dynamic process that is crucial for protecting the cell from challenges to genome integrity. Although many genome-wide…”
Get full text