Search Results - "Aris, John P."

Autophagy is required for extension of yeast chronological life span by rapamycin by Alvers, Ashley L., Wood, Michael S., Hu, Doreen, Kaywell, Amelia C., Dunn, Jr, William A., Aris, John P.

“…Rapamycin is an antibiotic that stimulates autophagy in a wide variety of eukaryotes, including the budding yeast Saccharomyces cerevisiae.  Low concentrations…”
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Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast by Aris, John P., Alvers, Ashley L., Ferraiuolo, Roy A., Fishwick, Laura K., Hanvivatpong, Amanda, Hu, Doreen, Kirlew, Christine, Leonard, Michael T., Losin, Kyle J., Marraffini, Michelle, Seo, Arnold Y., Swanberg, Veronica, Westcott, Jennifer L., Wood, Michael S., Leeuwenburgh, Christiaan, Dunn, William A.

“…We have previously shown that autophagy is required for chronological longevity in the budding yeast Saccharomyces cerevisiae. Here we examine the requirements…”
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Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae by Falcón, Alaric A, Chen, Shaoping, Wood, Michael S, Aris, John P

“…Acs2p is one of two acetyl-coenzyme A synthetases in Saccharomyces cerevisiae. We have prepared and characterized a monoclonal antibody specific for Acs2p and…”
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New insights into the role of mitochondria in aging: mitochondrial dynamics and more by Seo, Arnold Y, Joseph, Anna-Maria, Dutta, Debapriya, Hwang, Judy C.Y, Aris, John P, Leeuwenburgh, Christiaan

“…A decline in mitochondrial function plays a key role in the aging process and increases the incidence of age-related disorders. A deeper understanding of the…”
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Plasmid Accumulation Reduces Life Span in Saccharomyces cerevisiae by Falcón, Alaric A., Aris, John P.

“…Aging in the yeast Saccharomyces cerevisiae is under the control of multiple pathways. The production and accumulation of extrachromosomal rDNA circles (ERCs)…”
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Role of Histone Deacetylase Rpd3 in Regulating rRNA Gene Transcription and Nucleolar Structure in Yeast by Oakes, Melanie L., Siddiqi, Imran, French, Sarah L., Vu, Loan, Sato, Manabu, Aris, John P., Beyer, Ann L., Nomura, Masayasu

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A moonlighting metabolic protein influences repair at DNA double-stranded breaks by Torres-Machorro, Ana Lilia, Aris, John P, Pillus, Lorraine

“…Catalytically active proteins with divergent dual functions are often described as 'moonlighting'. In this work we characterize a new, chromatin-based function…”
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Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae by Alvers, Ashley L., Fishwick, Laura K., Wood, Michael S., Hu, Doreen, Chung, Hye S., Dunn Jr, William A., Aris, John P.

“…Summary Following cessation of growth, yeast cells remain viable in a nondividing state for a period of time known as the chronological lifespan (CLS)…”
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Impaired Ribosome Biogenesis Disrupts the Integration between Morphogenesis and Nuclear Duplication during the Germination of Aspergillus fumigatus by Bhabhra, Ruchi, Richie, Daryl L, Kim, H Stanley, Nierman, William C, Fortwendel, Jarrod, Aris, John P, Rhodes, Judith C, Askew, David S

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Resurrecting ancestral alcohol dehydrogenases from yeast by Benner, Steven A, Thomson, J Michael, Gaucher, Eric A, Burgan, Michelle F, De Kee, Danny W, Li, Tang, Aris, John P

“…Modern yeast living in fleshy fruits rapidly convert sugars into bulk ethanol through pyruvate. Pyruvate loses carbon dioxide to produce acetaldehyde, which is…”
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The UF family of hybrid phantoms of the developing human fetus for computational radiation dosimetry by Maynard, Matthew R, Geyer, John W, Aris, John P, Shifrin, Roger Y, Bolch, Wesley

“…Historically, the development of computational phantoms for radiation dosimetry has primarily been directed at capturing and representing adult and pediatric…”
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Saccharomyces cerevisiae Mod5p-II contains sequences antagonistic for nuclear and cytosolic locations by Tolerico, L.H. (Brown University, Providence, RI.), Benko, A.L, Aris, J.P, Stanford, D.R, Martin, N.C, Hopper, A.K

“…MOD5 encodes a tRNA modification activity located in three subcellular compartments. Alternative translation initiation generates Mod5p-I, located in the…”
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Gingival RAGE Expression in Calorie‐Restricted Versus ad Libitum–Fed Rats by Aris, John P., Elios, Megan C., Bimstein, Enrique, Wallet, Shanon M., Cha, Seunghee, Lakshmyya, Kesavalu N., Katz, Joseph

“…Background: The receptor for advanced glycation end products (RAGE) is a multiligand receptor expressed in a number of cell types, including gingival…”
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Loc1p is required for efficient assembly and nuclear export of the 60S ribosomal subunit by Urbinati, Carl R, Gonsalvez, Graydon B, Aris, John P, Long, Roy M

“…Loc1p is an exclusively nuclear dsRNA-binding protein that affects the asymmetric sorting of ASH1 mRNA to daughter cells in Saccharomyces cerevisiae. In…”
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Nop5p is a small nucleolar ribonucleoprotein component required for pre-18 S rRNA processing in yeast by Wu, P. (University of Florida, Gainesville), Brockenbrough, J.S, Metcalfe, A.C, Chen, S, Aris, J.P

“…We have identified a novel nucleolar protein, Nop5p, that is essential for growth in Saccharomyces cerevisiae . Monoclonal antibodies B47 and 37C12 recognize…”
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Nop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast by Hong, Bo, Brockenbrough, J. Scott, Wu, Pei, Aris, John P.

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2-micron circle plasmids do not reduce yeast life span by Falcon, Alaric A., Rios, Natalie, Aris, John P.

“…Extrachromosomal rDNA circles (ERCs) and recombinant origin-containing plasmids (ARS-plasmids) are thought to reduce replicative life span in the budding yeast…”
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Amino acid homeostasis and chronological longevity in Saccharomyces cerevisiae by Aris, John P, Fishwick, Laura K, Marraffini, Michelle L, Seo, Arnold Y, Leeuwenburgh, Christiaan, Dunn, Jr, William A

“…Understanding how non-dividing cells remain viable over long periods of time, which may be decades in humans, is of central importance in understanding…”
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Nucleolar protein Nop12p participates in synthesis of 25S rRNA in Saccharomyces cerevisiae by Wu, K, Wu, P, Aris, J P

“…A genetic screen for mutations synthetically lethal with temperature sensitive alleles of nop2 led to the identification of the nucleolar proteins Nop12p and…”
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Temperature sensitive nop2 alleles defective in synthesis of 25S rRNA and large ribosomal subunits in Saccharomyces cerevisiae by Hong, B, Wu, K, Brockenbrough, J S, Wu, P, Aris, J P

“…Using molecular genetic techniques, we have generated and characterized six temperature sensitive (ts) alleles of nop2. All failed to support growth at 37…”
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