Search Results - "Arif, Sefina"

Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes by van Lummel, Menno, Duinkerken, Gaby, van Veelen, Peter A, de Ru, Arnoud, Cordfunke, Robert, Zaldumbide, Arnaud, Gomez-Touriño, Iria, Arif, Sefina, Peakman, Mark, Drijfhout, Jan W, Roep, Bart O

“…Posttranslational modification (PTM) of islet autoantigens can cause lack of central tolerance in type 1 diabetes (T1D). Tissue transglutaminase (tTG),…”
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Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease by Verhagen, Johan, Yusuf, Norkhairin, Smith, Emma L., Whettlock, Emily M., Naran, Kerina, Arif, Sefina, Peakman, Mark

“…Aims/hypothesis The molecular basis for the pathological impact of specific HLA molecules on autoimmune diseases such as type 1 diabetes remains unclear…”
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Evaluating T cell responses prior to the onset of type 1 diabetes by Arif, Sefina, Yusuf, Norkhairin, Domingo‐Vila, Clara, Liu, Yuk‐Fun, Bingley, Polly J., Peakman, Mark

“…Aims In the current study we aimed to evaluat T cell phenotypes and metabolic profiles in high‐risk individuals who progressed to type 1 diabetes compared to…”
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GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells by Arif, Sefina, Gomez-Tourino, Iria, Kamra, Yogesh, Pujol-Autonell, Irma, Hanton, Emily, Tree, Timothy, Melandri, Daisy, Hull, Caroline, Wherrett, Diane K., Beam, Craig, Roep, Bart O., Lorenc, Anna, Peakman, Mark

“…Aims/hypothesis Antigen-specific therapy aims to modify inflammatory T cell responses in type 1 diabetes and restore immune tolerance. One strategy employs…”
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Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials by Arif, Sefina, Domingo-Vila, Clara, Pollock, Emily, Christakou, Eleni, Williams, Evangelia, Tree, Timothy I M

“…The number of immunotherapeutic clinical trials in type 1 diabetes currently being conducted is expanding, and thus there is a need for robust…”
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Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health by Arif, Sefina, Tree, Timothy I, Astill, Thomas P, Tremble, Jennifer M, Bishop, Amanda J, Dayan, Colin M, Roep, Bart O, Peakman, Mark

“…According to the quality of response they mediate, autoreactive T cells recognizing islet beta cell peptides could represent both disease effectors in the…”
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Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects by Arif, Sefina, Pujol-Autonell, Irma, Kamra, Yogesh, Williams, Evangelia, Yusuf, Norkhairin, Domingo-Vila, Clara, Shahrabi, Yasaman, Pollock, Emily, Khatri, Leena, Peakman, Mark, Tree, Timothy, Lorenc, Anna

“…Recent studies highlight the potentially important role of neoepitopes in breaking immune tolerance in type 1 diabetes. T cell reactivity to these neoepitopes…”
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Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes by HEROLD, Kevan C, BROOKS-WORRELL, Barbara, LACHIN, John M, PALMER, Jerry, DOSCH, H. Michael, PEAKMAN, Mark, GOTTLIEB, Peter, REIJONEN, Helena, ARIF, Sefina, SPAIN, Lisa M, THOMPSON, Clinton

“…Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes Kevan C. Herold 1 , Barbara…”
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Anti-TNFα therapy—killing two birds with one stone? by Arif, Sefina, PhD, Cox, Patricia, BSc, Afzali, Behdad, MRCP, Lombardi, Giovanna, Prof, Lechler, Robert I, Prof, Peakman, Mark, Prof, Mirenda, Vincenzo, MRCP

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Identification of a Naturally Processed Cytotoxic CD8 T-Cell Epitope of Coxsackievirus B4, Presented by HLA-A2.1 and Located in the PEVKEK Region of the P2C Nonstructural Protein by VARELA-CALVINO, Ruben, SKOWERA, Ania, ARIF, Sefina, PEAKMAN, Mark

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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T cells in type 1 diabetes: Instructors, regulators and effectors: A comprehensive review by Gomez-Tourino, Iria, Arif, Sefina, Eichmann, Martin, Peakman, Mark

“…Abstract Type 1 diabetes was one of the earliest disorders to be associated with the phenomenon of autoimmunity and is one of the most studied organ-specific…”
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Assessing effector T cells in type 1 diabetes by Arif, Sefina, Pujol-Autonell, Irma, Eichmann, Martin

“…The role of T cells specific for islet autoantigens is proven in pathogenesis of type 1 diabetes. Recently, there has been rapid expansion in the number of…”
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Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes by Arif, Sefina, Leete, Pia, Nguyen, Vy, Marks, Katherine, Nor, Nurhanani Mohamed, Estorninho, Megan, Kronenberg-Versteeg, Deborah, Bingley, Polly J, Todd, John A, Guy, Catherine, Dunger, David B, Powrie, Jake, Willcox, Abby, Foulis, Alan K, Richardson, Sarah J, de Rinaldis, Emanuele, Morgan, Noel G, Lorenc, Anna, Peakman, Mark

“…Studies in type 1 diabetes indicate potential disease heterogeneity, notably in the rate of β-cell loss, responsiveness to immunotherapies, and, in limited…”
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Cytotoxic Preproinsulin-specific CD8 T Cells in Type 1 Diabetes in Man by Skowera, Anna, Postdoctoral Fellow, King's College London, Department of Immunobiology, London, England, Ellis, Richard, Postdoctoral Fellow, King's College London, Department of Immunobiology, London, England, Tree, Timothy, Lecture, King's College London, Department of Immunobiology, London, England, Peakman, Mark, Professor of Clinical Immunology, King's College London, Department of Immunobiology, London, England, Arif, Sefina, Postdoctoral Fellow, King's College London, Department of Immunobiology, London, England

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Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes by Alhadj Ali, Mohammad, Liu, Yuk-Fun, Arif, Sefina, Tatovic, Danijela, Shariff, Hina, Gibson, Vivienne B, Yusuf, Norkhairin, Baptista, Roman, Eichmann, Martin, Petrov, Nedyalko, Heck, Susanne, Yang, Jennie H M, Tree, Timothy I M, Pujol-Autonell, Irma, Yeo, Lorraine, Baumard, Lucas, Stenson, Rachel, Howell, Alex, Clark, Alison, Boult, Zoe, Powrie, Jake, Adams, Laura, Wong, Florence S, Luzio, Stephen, Dunseath, Gareth, Green, Kate, O'Keefe, Alison, Bayly, Graham, Thorogood, Natasha, Andrews, Robert, Leech, Nicola, Joseph, Frank, Nair, Sunil, Seal, Susan, Cheung, HoYee, Beam, Craig, Hills, Robert, Peakman, Mark, Dayan, Colin M

“…Immunotherapy using short immunogenic peptides of disease-related autoantigens restores immune tolerance in preclinical disease models. We studied safety and…”
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Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes by Liu, Yuk-Fun, Powrie, Jake, Arif, Sefina, Yang, Jennie H M, Williams, Evangelia, Khatri, Leena, Joshi, Mamta, Lhuillier, Loic, Fountoulakis, Nikolaos, Smith, Emma, Beam, Craig, Lorenc, Anna, Peakman, Mark, Tree, Timothy

“…Type 1 diabetes is characterized by a loss of tolerance to pancreatic β-cell autoantigens and defects in regulatory T-cell (Treg) function. In preclinical…”
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Targeting of Tumor-Associated Glycoforms of MUC1 with CAR T Cells by Maher, John, Wilkie, Scott, Davies, David M., Arif, Sefina, Picco, Gianfranco, Julien, Sylvain, Foster, Julie, Burchell, Joy, Taylor-Papadimitriou, Joyce

“…We read with interest the manuscript by June and colleagues published recently in Immunity in which they describe targeting of aberrantly glycosylated…”
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Retargeting of Human T Cells to Tumor-Associated MUC1: The Evolution of a Chimeric Antigen Receptor by Wilkie, Scott, Picco, Gianfranco, Foster, Julie, Davies, David M, Julien, Sylvain, Cooper, Lucienne, Arif, Sefina, Mather, Stephen J, Taylor-Papadimitriou, Joyce, Burchell, Joy M, Maher, John

“…MUC1 is a highly attractive immunotherapeutic target owing to increased expression, altered glycosylation, and loss of polarity in >80% of human cancers. To…”
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Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death by ARIF, Sefina, MOORE, Fabrice, GUO CAI HUANG, GURZOV, Esteban N, PUJOL-BORRELL, Ricardo, EIZIRIK, Decio L, PEAKMAN, Mark, MARKS, Katherine, BOUCKENOOGHE, Thomas, DAYAN, Colin M, PLANAS, Raquel, VIVES-PI, Marta, POWRIE, Jake, TREE, Timothy, MARCHETTI, Piero

“…CD4 T-cells secreting interleukin (IL)-17 are implicated in several human autoimmune diseases, but their role in type 1 diabetes has not been defined. To…”
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CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope by Skowera, Ania, Ellis, Richard J, Varela-Calviño, Ruben, Arif, Sefina, Huang, Guo Cai, Van-Krinks, Cassie, Zaremba, Anna, Rackham, Chloe, Allen, Jennifer S, Tree, Timothy I M, Zhao, Min, Dayan, Colin M, Sewell, Andrew K, Unger, Wendy W, Unger, Wendy, Drijfhout, Jan W, Ossendorp, Ferry, Roep, Bart O, Peakman, Mark

“…The final pathway of beta cell destruction leading to insulin deficiency, hyperglycemia, and clinical type 1 diabetes is unknown. Here we show that circulating…”
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