Search Results - "Arie. B. Vaandrager"

Retinoids in health and disease: A role for hepatic stellate cells in affecting retinoid levels by Haaker, Maya W., Vaandrager, Arie B., Helms, J. Bernd

“…Vitamin A (retinol) is important for normal growth, vision and reproduction. It has a role in the immune response and the development of metabolic syndrome…”
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Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation by Tuohetahuntila, Maidina, Molenaar, Martijn R., Spee, Bart, Brouwers, Jos F., Wubbolts, Richard, Houweling, Martin, Yan, Cong, Du, Hong, VanderVen, Brian C., Vaandrager, Arie B., Helms, J. Bernd

“…Activation of hepatic stellate cells (HSCs) is a critical step in the development of liver fibrosis. During activation, HSCs lose their lipid droplets (LDs)…”
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ATGL and DGAT1 are involved in the turnover of newly synthesized triacylglycerols in hepatic stellate cells[S] by Tuohetahuntila, Maidina, Molenaar, Martijn R., Spee, Bart, Brouwers, Jos F., Houweling, Martin, Vaandrager, Arie B., Helms, J. Bernd

“…Hepatic stellate cell (HSC) activation is a critical step in the development of chronic liver disease. During activation, HSCs lose their lipid droplets (LDs)…”
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Identification of potential drugs for treatment of hepatic lipidosis in cats using an in vitro feline liver organoid system by Haaker, Maya W., Kruitwagen, Hedwig S., Vaandrager, Arie B., Houweling, Martin, Penning, Louis C., Molenaar, Martijn R., Wolferen, Monique E., Oosterhoff, Loes A., Spee, Bart, Helms, J. Bernd

“…Background Hepatic lipidosis is increasing in incidence in the Western world, with cats being particularly sensitive. When cats stop eating and start utilizing…”
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Replacement of retinyl esters by polyunsaturated triacylglycerol species in lipid droplets of hepatic stellate cells during activation by Testerink, Nicole, Ajat, Mokrish, Houweling, Martin, Brouwers, Jos F, Pully, Vishnu V, van Manen, Henk-Jan, Otto, Cees, Helms, J Bernd, Vaandrager, Arie B

“…Activation of hepatic stellate cells has been recognized as one of the first steps in liver injury and repair. During activation, hepatic stellate cells…”
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Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells by Tuohetahuntila, Maidina, Spee, Bart, Kruitwagen, Hedwig S., Wubbolts, Richard, Brouwers, Jos F., van de Lest, Chris H., Molenaar, Martijn R., Houweling, Martin, Helms, J. Bernd, Vaandrager, Arie B.

“…Hepatic stellate cell (HSC) activation is a critical step in the development of chronic liver disease. We previously observed that the levels of…”
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The CDP-ethanolamine Pathway and Phosphatidylserine Decarboxylation Generate Different Phosphatidylethanolamine Molecular Species by Bleijerveld, Onno B., Brouwers, Jos F.H.M., Vaandrager, Arie B., Helms, J. Bernd, Houweling, Martin

“…In mammalian cells, phosphatidylethanolamine (PtdEtn) is mainly synthesized via the CDP-ethanolamine (Kennedy) pathway and by decarboxylation of…”
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Depletion of phosphatidylcholine affects endoplasmic reticulum morphology and protein traffic at the Golgi complex by Testerink, Nicole, van der Sanden, Michiel H.M., Houweling, Martin, Helms, J. Bernd, Vaandrager, Arie B.

“…The mutant Chinese hamster ovary cell line MT58 contains a thermosensitive mutation in CTP:phosphocholine cytidylyltransferase, the regulatory enzyme in the…”
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Sex specific differences in hepatic and plasma lipid profiles in healthy cats pre and post spaying and neutering: relationship with feline hepatic lipidosis by Valtolina, Chiara, Vaandrager, Arie B, Favier, Robert P, Tuohetahuntila, Maidina, Kummeling, Anne, Jeusette, Isabelle, Rothuizen, Jan, Robben, Joris H

“…A link between lipid metabolism and disease has been recognized in cats. Since hepatic lipidosis is a frequent disorder in cats, the aim of the current study…”
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Molecular properties and biological functions of cGMP-dependent protein kinase II by Vaandrager, Arie B, Hogema, Boris M, de Jonge, Hugo R

“…Type II cGMP-dependent protein kinase (cGK II) is the protein product of one of two genes coding for cGKs in mammalian genomes. cGK II has a domain structure…”
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Inhibition of phosphatidylcholine synthesis induces expression of the endoplasmic reticulum stress and apoptosis-related protein CCAAT/enhancer-binding protein-homologous protein (CHOP/GADD153) by van der Sanden, Michiel H M, Houweling, Martin, van Golde, Lambert M G, Vaandrager, Arie B

“…Inhibition of de novo synthesis of phosphatidylcholine (PC) by some anti-cancer drugs such as hexadecylphosphocholine leads to apoptosis in various cell lines…”
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Oleic Acid Prevents Detrimental Effects of Saturated Fatty Acids on Bovine Oocyte Developmental Competence by AARDEMA, Hilde, VOS, Peter L. A. M, LOLICATO, Francesca, ROELEN, Bernard A. J, KNIJN, Hiemke M, VAANDRAGER, Arie B, BERND HELMS, J, GADELLA, Bart M

“…Mobilization of fatty acids from adipose tissue during metabolic stress will increase the amount of free fatty acids in blood and follicular fluid and, thus,…”
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Oleic Acid Prevents Detrimental Effects of Saturated Fatty Acids on Bovine Oocyte Developmental Competence1 by Aardema, Hilde, Vos, Peter L.A.M, Lolicato, Francesca, Roelen, Bernard A.J, Knijn, Hiemke M, Vaandrager, Arie B, Helms, J. Bernd, Gadella, Bart M

“…Mobilization of fatty acids from adipose tissue during metabolic stress will increase the amount of free fatty acids in blood and follicular fluid and, thus,…”
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Membrane Targeting of cGMP-Dependent Protein Kinase is Required for Cystic Fibrosis Transmembrane Conductance Regulator Cl-Channel Activation by Arie. B. Vaandrager, Smolenski, Albert, Tilly, Ben C., Houtsmuller, Adriaan B., Ehrich M. E. Ehlert, Alice G. M. Bot, Edixhoven, Marcel, Wendy E. M. Boomaars, Lohmann, Suzanne M., De Jonge, Hugo R.

“…A recently cloned isoform of cGMP-dependent protein kinase (cGK), designated type II, was implicated as the mediator of cGMP-provoked intestinal Cl-secretion…”
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Hepatic stellate cells retain the capacity to synthesize retinyl esters and to store neutral lipids in small lipid droplets in the absence of LRAT by Ajat, Mokrish, Molenaar, Martijn, Brouwers, Jos F.H.M., Vaandrager, Arie B., Houweling, Martin, Helms, J. Bernd

“…Hepatic stellate cells (HSCs) play an important role in liver physiology and under healthy conditions they have a quiescent and lipid-storing phenotype. Upon…”
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Induction of CCAAT/Enhancer-binding Protein (C/EBP)-homologous Protein/Growth Arrest and DNA Damage-inducible Protein 153 Expression during Inhibition of Phosphatidylcholine Synthesis Is Mediated via Activation of a C/EBP-activating Transcription Factor-responsive Element by van der Sanden, Michiel H M, Meems, Henriët, Houweling, Martin, Helms, J Bernd, Vaandrager, Arie B

“…The gene for the proapoptotic transcription factor CCAAT/enhancer-binding protein (C/EBP)-homologous protein/growth arrest and DNA damage-inducible protein 153…”
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Bovine Cumulus Cells Protect Maturing Oocytes from Increased Fatty Acid Levels by Massive Intracellular Lipid Storage by AARDEMA, Hilde, LOLICATO, Francesca, VAN DE LEST, Chris H. A, BROUWERS, Jos F, VAANDRAGER, Arie B, VAN TOL, Helena T. A, ROELEN, Bernard A. J, VOS, Peter L. A. M, HELMS, J. Bernd, GADELLA, Bart M

“…Metabolic conditions characterized by elevated free fatty acid concentrations in blood and follicular fluid are often associated with impaired female…”
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Control of the CDPethanolamine pathway in mammalian cells: effect of CTP:phosphoethanolamine cytidylyltransferase overexpression and the amount of intracellular diacylglycerol by Bleijerveld, Onno B, Klein, Wil, Vaandrager, Arie B, Helms, J Bernd, Houweling, Martin

“…For an insight regarding the control of PtdEtn (phosphatidylethanolamine) synthesis via the CDPethanolamine pathway, rat liver cDNA encoding ECT…”
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Some Lipid Droplets Are More Equal Than Others: Different Metabolic Lipid Droplet Pools in Hepatic Stellate Cells by Molenaar, Martijn R, Vaandrager, Arie B, Helms, J Bernd

“…Hepatic stellate cells (HSCs) are professional lipid-storing cells and are unique in their property to store most of the retinol (vitamin A) as retinyl esters…”
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Iron ions derived from the nitric oxide donor sodium nitroprusside inhibit mineralization by Huitema, Leonie F.A., van Weeren, P. René, Barneveld, Ab, van de Lest, Chris H.A., Helms, J. Bernd, Vaandrager, Arie B.

“…Sodium nitroprusside (SNP) is a nitric oxide (NO) donor drug, which is therapeutically used as a vasodilating drug in heart transplantations. In our previous…”
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