Search Results - "Aricescu, A. Radu"

Crystal structure of a human GABAA receptor by Miller, Paul S., Aricescu, A. Radu

“…Type-A γ-aminobutyric acid receptors (GABA A Rs) are the principal mediators of rapid inhibitory synaptic transmission in the human brain. A decline in GABA A…”
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Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer by Laverty, Duncan, Desai, Rooma, Uchański, Tomasz, Masiulis, Simonas, Stec, Wojciech J., Malinauskas, Tomas, Zivanov, Jasenko, Pardon, Els, Steyaert, Jan, Miller, Keith W., Aricescu, A. Radu

“…Type A γ-aminobutyric acid (GABA A ) receptors are pentameric ligand-gated ion channels and the main drivers of fast inhibitory neurotransmission in the…”
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Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins by Elegheert, Jonathan, Behiels, Ester, Bishop, Benjamin, Scott, Suzanne, Woolley, Rachel E., Griffiths, Samuel C., Byrne, Eamon F. X., Chang, Veronica T., Stuart, David I., Jones, E. Yvonne, Siebold, Christian, Aricescu, A. Radu

“…Structural, biochemical and biophysical studies of eukaryotic soluble and membrane proteins require their production in milligram quantities. Although…”
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Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum by Kakegawa, Wataru, Mitakidis, Nikolaos, Miura, Eriko, Abe, Manabu, Matsuda, Keiko, Takeo, Yukari H, Kohda, Kazuhisa, Motohashi, Junko, Takahashi, Akiyo, Nagao, Soichi, Muramatsu, Shin-ichi, Watanabe, Masahiko, Sakimura, Kenji, Aricescu, A Radu, Yuzaki, Michisuke

“…Neuronal networks are dynamically modified by selective synapse pruning during development and adulthood. However, how certain connections win the competition…”
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A synthetic synaptic organizer protein restores glutamatergic neuronal circuits by Suzuki, Kunimichi, Elegheert, Jonathan, Song, Inseon, Sasakura, Hiroyuki, Senkov, Oleg, Matsuda, Keiko, Kakegawa, Wataru, Clayton, Amber J, Chang, Veronica T, Ferrer-Ferrer, Maura, Miura, Eriko, Kaushik, Rahul, Ikeno, Masashi, Morioka, Yuki, Takeuchi, Yuka, Shimada, Tatsuya, Otsuka, Shintaro, Stoyanov, Stoyan, Watanabe, Masahiko, Takeuchi, Kosei, Dityatev, Alexander, Aricescu, A Radu, Yuzaki, Michisuke

“…Neuronal synapses undergo structural and functional changes throughout life, which are essential for nervous system physiology. However, these changes may also…”
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GluD1 binds GABA and controls inhibitory plasticity by Piot, Laura, Heroven, Christina, Bossi, Simon, Zamith, Joseph, Malinauskas, Tomas, Johnson, Chris, Wennagel, Doris, Stroebel, David, Charrier, Cécile, Aricescu, A Radu, Mony, Laetitia, Paoletti, Pierre

“…Fast synaptic neurotransmission in the vertebrate central nervous system relies primarily on ionotropic glutamate receptors (iGluRs), which drive neuronal…”
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Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins by Matsuda, Keiko, Budisantoso, Timotheus, Mitakidis, Nikolaos, Sugaya, Yuki, Miura, Eriko, Kakegawa, Wataru, Yamasaki, Miwako, Konno, Kohtarou, Uchigashima, Motokazu, Abe, Manabu, Watanabe, Izumi, Kano, Masanobu, Watanabe, Masahiko, Sakimura, Kenji, Aricescu, A. Radu, Yuzaki, Michisuke

“…Postsynaptic kainate-type glutamate receptors (KARs) regulate synaptic network activity through their slow channel kinetics, most prominently at mossy fiber…”
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Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent by Thimaradka, Vikram, Hoon Oh, Jae, Heroven, Christina, Radu Aricescu, A., Yuzaki, Michisuke, Tamura, Tomonori, Hamachi, Itaru

“…[Display omitted] The ability to incorporate a desired functionality into proteins of interest in a site-specific manner can provide powerful tools for…”
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Atomic-resolution monitoring of protein maturation in live human cells by NMR by Banci, Lucia, Barbieri, Letizia, Bertini, Ivano, Luchinat, Enrico, Secci, Erica, Zhao, Yuguang, Aricescu, A Radu

“…Analysis of proteins within their native environment can confirm and extend in vitro –derived conclusions. NMR analysis of superoxide dismutase 1 in live human…”
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Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM by Uchański, Tomasz, Masiulis, Simonas, Fischer, Baptiste, Kalichuk, Valentina, López-Sánchez, Uriel, Zarkadas, Eleftherios, Weckener, Miriam, Sente, Andrija, Ward, Philip, Wohlkönig, Alexandre, Zögg, Thomas, Remaut, Han, Naismith, James H., Nury, Hugues, Vranken, Wim, Aricescu, A. Radu, Pardon, Els, Steyaert, Jan

“…Nanobodies are popular and versatile tools for structural biology. They have a compact single immunoglobulin domain organization, bind target proteins with…”
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Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation by Farhy-Tselnicker, Isabella, van Casteren, Adriana C.M., Lee, Aletheia, Chang, Veronica T., Aricescu, A. Radu, Allen, Nicola J.

“…The generation of precise synaptic connections between developing neurons is critical to the formation of functional neural circuits. Astrocyte-secreted…”
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Structural basis for integration of GluD receptors within synaptic organizer complexes by Elegheert, Jonathan, Kakegawa, Wataru, Clay, Jordan E., Shanks, Natalie F., Behiels, Ester, Matsuda, Keiko, Kohda, Kazuhisa, Miura, Eriko, Rossmann, Maxim, Mitakidis, Nikolaos, Motohashi, Junko, Chang, Veronica T., Siebold, Christian, Greger, Ingo H., Nakagawa, Terunaga, Yuzaki, Michisuke, Aricescu, A. Radu

“…Ionotropic glutamate receptor (iGIuR) family members are integrated into supramolecular complexes that modulate their location and function at excitatory…”
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A time- and cost-efficient system for high-level protein production in mammalian cells by Aricescu, A. Radu, Lu, Weixian, Jones, E. Yvonne

“…Most proteins for structural biology studies are produced by high‐level expression in Escherichia coli. However, pro­kary­otic based expression systems fail to…”
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Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling by Chen, Shuo, Bubeck, Doryen, MacDonald, Bryan T., Liang, Wen-Xue, Mao, Jian-Hua, Malinauskas, Tomas, Llorca, Oscar, Aricescu, A. Radu, Siebold, Christian, He, Xi, Jones, E. Yvonne

“…LDL-receptor-related protein 6 (LRP6), alongside Frizzled receptors, transduces Wnt signaling across the plasma membrane. The LRP6 ectodomain comprises four…”
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Proteoglycan-Specific Molecular Switch for RPTPσ Clustering and Neuronal Extension by Coles, Charlotte H., Shen, Yingjie, Tenney, Alan P., Siebold, Christian, Sutton, Geoffrey C., Lu, Weixian, Gallagher, John T., Jones, E. Yvonne, Flanagan, John G., Aricescu, A. Radu

“…Heparan and chondroitin sulfate proteoglycans (HSPGs and CSPGs, respectively) regulate numerous cell surface signaling events, with typically opposite effects…”
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A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis by Altemose, Nicolas, Noor, Nudrat, Bitoun, Emmanuelle, Tumian, Afidalina, Imbeault, Michael, Chapman, J Ross, Aricescu, A Radu, Myers, Simon R

“…PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRDM9-bound loci do not become recombination hotspots. To…”
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Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice by Salzer, Ralf, Clark, Jordan J., Vaysburd, Marina, Chang, Veronica T., Albecka, Anna, Kiss, Leo, Sharma, Parul, Gonzalez Llamazares, Andres, Kipar, Anja, Hiscox, Julian A., Owen, Andrew, Aricescu, A. Radu, Stewart, James P., James, Leo C., Löwe, Jan

“…The COVID‐19 pandemic, caused by the SARS‐CoV‐2 coronavirus, has triggered a worldwide health emergency. Here, we show that ferritin‐like Dps from…”
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Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins by Elegheert, Jonathan, Cvetkovska, Vedrana, Clayton, Amber J., Heroven, Christina, Vennekens, Kristel M., Smukowski, Samuel N., Regan, Michael C., Jia, Wanyi, Smith, Alexandra C., Furukawa, Hiro, Savas, Jeffrey N., de Wit, Joris, Begbie, Jo, Craig, Ann Marie, Aricescu, A. Radu

“…Neuroligin-neurexin (NL-NRX) complexes are fundamental synaptic organizers in the central nervous system. An accurate spatial and temporal control of NL-NRX…”
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An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly by Seiradake, Elena, Sutton, Geoff, Jones, E Yvonne, Harlos, Karl, Aricescu, A Radu

“…Eph receptors are cell surface protein tyrosine kinases that mediate cell-cell communication. The crystal structure of the full ectodomain of unliganded human…”
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Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1 by Siebold, Christian, Jones, E Yvonne, Malinauskas, Tomas, Aricescu, A Radu, Lu, Weixian

“…WIF-1 inhibits Wnt signaling by binding Wnt ligands. Structural and biochemical analysis of WIF-1 shows the EGF-like domains wrapping back to contact the…”
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