Search Results - "Ariazi, Jennifer L."

Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia by Ariazi, Jennifer L, Duffy, Kevin J, Adams, David F, Fitch, Duke M, Luo, Lusong, Pappalardi, Melissa, Biju, Mangatt, DiFilippo, Erin Hugger, Shaw, Tony, Wiggall, Ken, Erickson-Miller, Connie

“…Decreased erythropoietin (EPO) production, shortened erythrocyte survival, and other factors reducing the response to EPO contribute to anemia in patients who…”
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Chronic Inhibition of Hypoxia-inducible Factor Prolyl 4-hydroxylase Improves Ventricular Performance, Remodeling, and Vascularity After Myocardial Infarction in the Rat by Bao, Weike, Qin, Pu, Needle, Saul, Erickson-Miller, Connie L, Duffy, Kevin J, Ariazi, Jennifer L, Zhao, Shufang, Olzinski, Alan R, Behm, David J, Teg Pipes, G C, Jucker, Beat M, Hu, Erding, Lepore, John J, Willette, Robert N

“…BACKGROUND:Hypoxia inducible factors (HIFs) are transcription factors that are regulated by HIF-prolyl 4-hydroxylases (PHDs) in response to changes in oxygen…”
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Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1 by Cheung, Mui, Tangirala, Raghuram S, Bethi, Sridhar R, Joshi, Hemant V, Ariazi, Jennifer L, Tirunagaru, Vijaya G, Kumar, Sanjay

“…Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) plays an important role in triglyceride synthesis and is a target of interest for the treatment of metabolic…”
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Mammary glands of sexually immature rats are more susceptible than those of mature rats to the carcinogenic, lethal, and mutagenic effects of N-nitroso-N-methylurea by Ariazi, Jennifer L., Haag, Jill D., Lindstrom, Mary J., Gould, Michael N.

“…Knowing that the prepubertal period is a time of enhanced susceptibility for radiation‐induced human breast cancer, we used the Fischer 344 rat model to…”
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Estrogen receptors as therapeutic targets in breast cancer by Ariazi, Eric A, Ariazi, Jennifer L, Cordera, Fernando, Jordan, V Craig

“…The estrogen receptor alpha (ERalpha) has proven to be the single most important target in breast cancer over the last 30 years. The use of the selective ER…”
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Methylguanine methyltransferase activity deficiency in immature rat mammary epithelial cells parallels increased carcinogenic susceptibility by Ariazi, Jennifer L., Haag, Jill D., Gould, Michael N.

“…The prepubertal breast is more susceptible than the mature breast to the carcinogenic effects of ionizing radiation, and potentially to cigarette smoke and…”
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Rational Design, Synthesis, and SAR of a Novel Thiazolopyrimidinone Series of Selective PI3K-beta Inhibitors by Lin, Hong, Schulz, Mark J, Xie, Ren, Zeng, Jin, Luengo, Juan I, Squire, Michael D, Tedesco, Rosanna, Qu, Junya, Erhard, Karl, Mack, James F, Raha, Kaushik, Plant, Ramona, Rominger, Cynthia M, Ariazi, Jennifer L, Sherk, Christian S, Schaber, Michael D, McSurdy-Freed, Jeanelle, Spengler, Michael D, Davis, Charles B, Hardwicke, Mary Ann, Rivero, Ralph A

“…A novel thiazolopyrimidinone series of PI3K-beta selective inhibitors has been identified. This chemotype has provided an excellent tool compound, 18, that…”
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Emerging principles for the development of resistance to antihormonal therapy: Implications for the clinical utility of fulvestrant by Ariazi, Eric A., Lewis-Wambi, Joan S., Gill, Shaun D., Pyle, Jennifer R., Ariazi, Jennifer L., Kim, Helen R., Sharma, Catherine G.N., Cordera, Fernando, Shupp, Heather A., Li, Tianyu, Jordan, V. Craig

“…We seek to evaluate the clinical consequences of resistance to antihormonal therapy by studying analogous animal xenograft models. Two approaches were taken:…”
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