Search Results - "Arias‐Fuenzalida, Jonathan"

Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐Cyclodextrin Treatment by Jarazo, Javier, Barmpa, Kyriaki, Modamio, Jennifer, Saraiva, Cláudia, Sabaté‐Soler, Sònia, Rosety, Isabel, Griesbeck, Anne, Skwirblies, Florian, Zaffaroni, Gaia, Smits, Lisa M., Su, Jihui, Arias‐Fuenzalida, Jonathan, Walter, Jonas, Gomez‐Giro, Gemma, Monzel, Anna S., Qing, Xiaobing, Vitali, Armelle, Cruciani, Gerald, Boussaad, Ibrahim, Brunelli, Francesco, Jäger, Christian, Rakovic, Aleksandar, Li, Wen, Yuan, Lin, Berger, Emanuel, Arena, Giuseppe, Bolognin, Silvia, Schmidt, Ronny, Schröder, Christoph, Antony, Paul M.A., Klein, Christine, Krüger, Rejko, Seibler, Philip, Schwamborn, Jens C.

“…ABSTRACT Background The etiology of Parkinson's disease (PD) is only partially understood despite the fact that environmental causes, risk factors, and…”
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Generation of nonviral integration-free human iPS cell line KISCOi001-A from normal human fibroblasts, under defined xeno-free and feeder-free conditions by Inzunza, Jose, Arias-Fuenzalida, Jonathan, Segura-Aguilar, Juan, Nalvarte, Ivan, Varshney, Mukesh

“…KISCOi001-A is a healthy feeder-free and fully characterized human induced pluripotent stem (iPS) cell line cultured under xeno-free and defined conditions…”
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CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons by Qing, Xiaobing, Walter, Jonas, Jarazo, Javier, Arias-Fuenzalida, Jonathan, Hillje, Anna-Lena, Schwamborn, Jens C.

“…The p.G2019S mutation of the leucine-rich repeat kinase 2 (LRRK2) has been identified as the most prevalent genetic cause of familial and sporadic Parkinson's…”
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FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling by Arias-Fuenzalida, Jonathan, Jarazo, Javier, Qing, Xiaobing, Walter, Jonas, Gomez-Giro, Gemma, Nickels, Sarah Louise, Zaehres, Holm, Schöler, Hans Robert, Schwamborn, Jens Christian

“…Genome editing and human induced pluripotent stem cells hold great promise for the development of isogenic disease models and the correction of…”
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Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality by Walter, Jonas, Bolognin, Silvia, Antony, Paul M.A., Nickels, Sarah L., Poovathingal, Suresh K., Salamanca, Luis, Magni, Stefano, Perfeito, Rita, Hoel, Fredrik, Qing, Xiaobing, Jarazo, Javier, Arias-Fuenzalida, Jonathan, Ignac, Tomasz, Monzel, Anna S., Gonzalez-Cano, Laura, Pereira de Almeida, Luis, Skupin, Alexander, Tronstad, Karl J., Schwamborn, Jens C.

“…Emerging evidence suggests that Parkinson's disease (PD), besides being an age-associated disorder, might also have a neurodevelopment component. Disruption of…”
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Automated high-throughput high-content autophagy and mitophagy analysis platform by Arias-Fuenzalida, Jonathan, Jarazo, Javier, Walter, Jonas, Gomez-Giro, Gemma, Forster, Julia I., Krueger, Rejko, Antony, Paul M. A., Schwamborn, Jens C.

“…Autophagic processes play a central role in cellular homeostasis. In pathological conditions, the flow of autophagy can be affected at multiple and distinct…”
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Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis by Gomez-Giro, Gemma, Arias-Fuenzalida, Jonathan, Jarazo, Javier, Zeuschner, Dagmar, Ali, Muhammad, Possemis, Nina, Bolognin, Silvia, Halder, Rashi, Jäger, Christian, Kuper, Willemijn F E, van Hasselt, Peter M, Zaehres, Holm, Del Sol, Antonio, van der Putten, Herman, Schöler, Hans R, Schwamborn, Jens C

“…The juvenile form of neuronal ceroid Lipofuscinosis (JNCL) is the most common form within this group of rare lysosomal storage disorders, causing pediatric…”
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Generation of a human induced pluripotent stem cell line (PHAi003) from a primary immunodeficient patient with CD70 mutation by Arias-Fuenzalida, Jonathan, Yu, Jingwei, Abolhassani, Hassan, Du, Likun, Custodio, Joaquin, Pan-Hammarström, Qiang

“…Primary immunodeficiency (PID) comprises a heterogeneous group of over 330 genetic disorders, caused mainly by single-gene mutations, such as CD70. We…”
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Generation of human induced pluripotent stem cell lines from patients with selective IgA deficiency by Arias-Fuenzalida, Jonathan, Yu, Jingwei, Du, Likun, Custodio, Joaquin, Notarangelo, Luigi D., Hammarström, Lennart, Pan-Hammarström, Qiang

“…Selective immunoglobulin-A deficiency (IgAD) is the most common primary immunodeficiency (PID) in the Western world and results in higher susceptibility to…”
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The Effects of Ganglioside-Monosialic Acid in Taxane-Induced Peripheral Neurotoxicity in Patients with Breast Cancer: A Randomized Trial by Su, Yanhong, Huang, Jiajia, Wang, Shusen, Unger, Joseph M, Arias-Fuenzalida, Jonathan, Shi, Yanxia, Li, Jibin, Gao, Yongxiang, Shi, Wei, Wang, Xinyue, Peng, Roujun, Xu, Fei, An, Xin, Xue, Cong, Xia, Wen, Hong, Ruoxi, Zhong, Yongyi, Lin, Ying, Huang, Heng, Zhang, Anqin, Zhang, Lehong, Cai, Li, Zhang, Jinxin, Yuan, Zhongyu

“…Abstract Background Taxane-induced peripheral neuropathy (TIPN) is a dose-limiting adverse effect. Ganglioside-monosialic acid (GM1) functions as a…”
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