Search Results - "Arias, Hugo R"

Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators by Manetti, Dina, Dei, Silvia, Arias, Hugo R, Braconi, Laura, Gabellini, Alessio, Teodori, Elisabetta, Romanelli, Maria Novella

“…Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent agonists, allosteric activating PAMs and neutral or silent allosteric…”
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The role of inflammation in Alzheimer's disease by Tuppo, Ehab E., Arias, Hugo R.

“…Considerable evidence gained over the past decade has supported the conclusion that neuroinflammation is associated with Alzheimer's disease (AD) pathology…”
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Role of Nicotinic and Muscarinic Receptors on Synaptic Plasticity and Neurological Diseases by Fuenzalida, Marco, Pérez, Miguel Ángel, Arias, Hugo R

“…The cholinergic activity in the brain is fundamental for cognitive functions. The modulatory activity of the neurotransmitter acetylcholine (ACh) is mediated…”
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Is the Antidepressant Activity of Selective Serotonin Reuptake Inhibitors Mediated by Nicotinic Acetylcholine Receptors? by Arias, Hugo R, Targowska-Duda, Katarzyna M, García-Colunga, Jesús, Ortells, Marcelo O

“…It is generally assumed that selective serotonin reuptake inhibitors (SSRIs) induce antidepressant activity by inhibiting serotonin (5-HT) reuptake…”
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Modulation of the mammalian GABAA receptor by type I and type II positive allosteric modulators of the α7 nicotinic acetylcholine receptor by Arias, Hugo R., Germann, Allison L., Pierce, Spencer R., Sakamoto, Seiji, Ortells, Marcelo O., Hamachi, Itaru, Akk, Gustav

“…Background and Purpose Positive allosteric modulators of the α7 nicotinic acetylcholine (nACh) receptor (α7‐PAMs) possess promnesic and procognitive properties…”
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Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective by Andersen, Natalia D., Nielsen, Beatriz E., Corradi, Jeremías, Tolosa, María F., Feuerbach, Dominik, Arias, Hugo R., Bouzat, Cecilia

“…Enhancement of α7 nicotinic receptor (nAChR) function by positive allosteric modulators (PAMs) is a promising therapeutic strategy to improve cognitive…”
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3-Furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic receptor, reverses schizophrenia-like cognitive and social deficits in rats by Potasiewicz, Agnieszka, Hołuj, Małgorzata, Kos, Tomasz, Popik, Piotr, Arias, Hugo R., Nikiforuk, Agnieszka

“…The cognitive impairments and negative symptoms experienced by schizophrenia patients still await effective treatment. Alpha7 nicotinic acetylcholine receptors…”
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Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation by Arias, Hugo R., Micheli, Laura, Rudin, Deborah, Bento, Ophelie, Borsdorf, Saskia, Ciampi, Clara, Marin, Philippe, Ponimaskin, Evgeni, Manetti, Dina, Romanelli, Maria Novella, Ghelardini, Carla, Liechti, Matthias E., Di Cesare Mannelli, Lorenzo

“…The aim of this study was to determine the anti-hypersensitivity activity of novel non-hallucinogenic compounds derived from iboga alkaloids (i.e., ibogalogs),…”
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Molecular mechanisms and binding site locations for noncompetitive antagonists of nicotinic acetylcholine receptors by Arias, Hugo R., Bhumireddy, Pankaj, Bouzat, Cecilia

“…Nicotinic acetylcholine receptors are pentameric proteins that belong to the Cys-loop receptor superfamily. Their essential mechanism of functioning is to…”
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(E)‑3-Furan-2-yl‑N‑p‑tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation by Arias, Hugo R, Ghelardini, Carla, Lucarini, Elena, Tae, Han-Shen, Yousuf, Arsalan, Marcovich, Irina, Manetti, Dina, Romanelli, Maria Novella, Elgoyhen, Ana Belén, Adams, David J, Di Cesare Mannelli, Lorenzo

“…The main objective of this study was to determine whether (E)-3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2) and its structural derivative DM489 produce…”
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Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABAA Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor by Pierce, Spencer R., Germann, Allison L., Xu, Sophia Q., Menon, Saumith L., Ortells, Marcelo O., Arias, Hugo R., Akk, Gustav

“…The positive allosteric modulators (PAMs) of the α7 nicotinic receptor N-(5-Cl-2-hydroxyphenyl)-N′-[2-Cl-5-(trifluoromethyl)phenyl]-urea (NS-1738) and…”
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Role of non-neuronal nicotinic acetylcholine receptors in angiogenesis by Arias, Hugo R, Richards, Victoria E, Ng, David, Ghafoori, Mary E, Le, Vanique, Mousa, Shaker A

“…Angiogenesis is a critical physiological process for cell survival and development. Endothelial cells, necessary for the course of angiogenesis, express…”
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3-Furan-2-yl-N-p-tolyl-acrylamide, a highly selective positive allosteric modulator of α7 nicotinic receptors, produces anxiolytic-like activity in mice by Targowska-Duda, Katarzyna M, Budzynska, Barbara, Michalak, Agnieszka, Jozwiak, Krzysztof, Biala, Grazyna, Arias, Hugo R

“…Background: Several lines of investigations support the idea that nicotinic acetylcholine receptors modulate neuronal pathways involved in anxiety and…”
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Similarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological Profile by Möller-Acuña, Patricia, Contreras-Riquelme, J Sebastián, Rojas-Fuentes, Cecilia, Nuñez-Vivanco, Gabriel, Alzate-Morales, Jans, Iturriaga-Vásquez, Patricio, Arias, Hugo R, Reyes-Parada, Miguel

“…Evidence from systems biology indicates that promiscuous drugs, i.e. those that act simultaneously at various protein targets, are clinically better in terms…”
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Novel Positive Allosteric Modulators of the Human α7 Nicotinic Acetylcholine Receptor by Arias, Hugo R, Gu, Ruo-Xu, Feuerbach, Dominik, Guo, Bao-Bao, Ye, Yong, Wei, Dong-Qing

“…The pharmacological activity of a series of novel amide derivatives was characterized on several nicotinic acetylcholine receptors (AChRs). Ca2+ influx results…”
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Inhibitory mechanisms and binding site location for serotonin selective reuptake inhibitors on nicotinic acetylcholine receptors by Arias, Hugo R., Feuerbach, Dominik, Bhumireddy, Pankaj, Ortells, Marcelo O.

“…Functional and structural approaches were used to examine the inhibitory mechanisms and binding site location for fluoxetine and paroxetine, two serotonin…”
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To what extent may aminochrome increase the vulnerability of dopaminergic neurons in the context of Parkinson's disease by Chagraoui, Abdeslam, Anouar, Youssef, De Deurwaerdere, Philippe, Arias, Hugo R.

“…Parkinson's disease (PD) is a neurodegenerative disorder that progresses over time and is characterized by preferential reduction of dopaminergic neurons in…”
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Is the inhibition of nicotinic acetylcholine receptors by bupropion involved in its clinical actions? by Arias, Hugo R.

“…In this mini review we will focus on those molecular and cellular mechanisms exerted by bupropion (BP), ultimately leading to the antidepressant and…”
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Marine Toxins Targeting Ion Channels by Arias, Hugo R.

“…This introductory minireview points out the importance of ion channels for cell communication. The basic concepts on the structure and function of ion channels…”
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Theoretical studies of Alzheimer’s disease drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine (GTS-21) and its derivatives by Wei, Dong-Qing, Sirois, Suzane, Du, Qi-Shi, Arias, Hugo R., Chou, Kuo-Chen

“…Theoretical and molecular modeling studies have been conducted for understanding the details of how 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride…”
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