Search Results - "Ariëns, R."

Fibrin(ogen) and thrombotic disease by Ariëns, R. A. S.

“…Summary Fibrinogen is an abundant plasma protein that, when converted to fibrin by thrombin, provides the main building blocks for the clot. Dys‐, a‐, and…”
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Dysfibrinogenemia: from molecular anomalies to clinical manifestations and management by Casini, A., Neerman‐Arbez, M., Ariëns, R. A., Moerloose, P.

“…Summary Congenital dysfibrinogenemia is a qualitative congenital fibrinogen disorder characterized by normal antigen levels of a dysfunctional fibrinogen. The…”
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The effect of blood coagulation factor XIII on fibrin clot structure and fibrinolysis by Hethershaw, E. L., Cilia La Corte, A. L., Duval, C., Ali, M., Grant, P. J., Ariëns, R. A. S., Philippou, H.

“…Summary Background Factor XIII is a 320 kDa tetramer, comprising two enzymatic A‐subunits and two carrier B‐subunits (FXIII A2B2). Activated FXIII (FXIIIa)…”
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Procoagulant changes in fibrin clot structure in patients with cirrhosis are associated with oxidative modifications of fibrinogen by Hugenholtz, G. C. G., Macrae, F., Adelmeijer, J., Dulfer, S., Porte, R. J., Lisman, T., Ariëns, R. A. S.

“…Essentials Patients with cirrhosis have hemostatic changes, which may contribute to a risk of thrombosis. This in vitro study compares clot formation and…”
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Neutrophils can promote clotting via FXI and impact clot structure via neutrophil extracellular traps in a distinctive manner in vitro by Shi, Y., Gauer, J. S., Baker, S. R., Philippou, H., Connell, S. D., Ariëns, R. A. S.

“…Neutrophils and neutrophil extracellular traps (NETs) have been shown to be involved in coagulation. However, the interactions between neutrophils or NETs and…”
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In vitro batch fermentation of (un)saturated homogalacturonan oligosaccharides by Zwolschen, J W, Vos, A P, Ariëns, R M C, Schols, H A

“…Pectin, predominantly present within plant cell walls, is a dietary fiber that potentially induces distinct health effects depending on its molecular…”
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Gender-Specific Alterations in Fibrin Structure Function in Type 2 Diabetes: Associations with Cardiometabolic and Vascular Markers by Alzahrani, Saad H, Hess, Katharina, Price, Jackie F, Strachan, Mark, Baxter, Paul D, Cubbon, Richard, Phoenix, Fladia, Gamlen, T, Ariëns, R. A. S, Grant, Peter J, Ajjan, Ramzi A

“…Context: Diabetes is associated with increased incidence of atherothrombotic disease. The fibrin network forms the backbone of the arterial thrombus, and…”
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Ex vivo addition of fibrinogen concentrate improves the fibrin network structure in plasma samples taken during liver transplantation by Groeneveld, D. J., Adelmeijer, J., Hugenholtz, G. C. G., Ariëns, R. A. S., Porte, R. J., Lisman, T.

“…Summary Background Optimal hemostatic management during orthotopic liver transplantation (OLT) remains a challenge. The cause of bleeding during OLT is…”
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Fibrin clot structure in patients with congenital dysfibrinogenaemia by Casini, A, Duval, C, Pan, X, Tintillier, V, Biron-Andreani, C, Ariëns, R.A.S

“…Abstract The clinical phenotype of patients with congenital dysfibrinogenaemia is highly heterogeneous, from absence of symptoms to mild bleeding, or…”
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Evidence that fibrinogen γ′ directly interferes with protofibril growth: implications for fibrin structure and clot stiffness by ALLAN, P., UITTE de WILLIGE, S., ABOU‐SALEH, R. H., CONNELL, S. D., ARIËNS, R. A. S.

“…Background:  Fibrinogen contains an alternatively spliced γ‐chain (γ′), which mainly exists as a heterodimer with the common γA‐chain (γA/γ′). Fibrinogen γ′…”
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The influence of type 2 diabetes on fibrin structure and function by DUNN, E. J, ARIËNS, R. A. S, GRANT, P. J

“…The precise mechanisms underlying the increased risk of cardiovascular disease (CVD) in type 2 diabetes are unclear. Fibrin clot structure has been related to…”
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Molecular mechanisms involved in the resistance of fibrin to clot lysis by plasmin in subjects with type 2 diabetes mellitus by DUNN, E. J, PHILIPPOU, H, ARIËNS, R. A. S, GRANT, P. J

“…The aim of this study was to determine the influence of type 2 diabetes on fibrinolysis by assessing interactions between the regulatory components of…”
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Elimination of coagulation factor XIII from fibrinogen preparations by Smith, E. L., Cardinali, B., Ping, L., Ariëns, R. A. S., Philippou, H.

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Effects of Aspirin on Clot Structure and Fibrinolysis Using a Novel In Vitro Cellular System by AJJAN, R. A, STANDEVEN, K. F, KHANBHAI, M, PHOENIX, F, GERSH, K. C, WEISEL, J. W, KEARNEY, M. T, ARIËNS, R. A. S, GRANT, P. J

“…The purpose of this study was to investigate the direct effects of aspirin on fibrin structure/function. Chinese Hamster Ovary cell lines stably transfected…”
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Inhibition of thrombin‐mediated factor V activation contributes to the anticoagulant activity of fibrinogen γ by Omarova, F., Uitte De Willige, S., Ariëns, R. A. S., Rosing, J., Bertina, R. M., Castoldi, E.

“…Summary Background Besides its role in blood clotting, fibrinogen exerts a poorly understood anticoagulant function by binding thrombin and modulating its…”
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Aspirin therapy is associated with less compact fibrin networks and enhanced fibrinolysis in patients with abdominal aortic aneurysm by Bailey, M. A., Aggarwal, R., Bridge, K. I., Griffin, K. J., Iqbal, F., Phoenix, F., Purdell‐Lewis, J., Thomas, T., Johnson, A. B., Ariëns, R. A. S., Scott, D. J. A., Ajjan, R. A.

“…Summary Objective Thrombotic changes in fibrin networks contribute to increased cardiovascular risk in patients with abdominal aortic aneurysm (AAA). Given…”
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The role of β‐barrels 1 and 2 in the enzymatic activity of factor XIII A‐subunit by Hethershaw, E. L., Adamson, P. J., Smith, K. A., Goldsberry, W. N., Pease, R. J., Radford, S. E., Grant, P. J., Ariëns, R. A. S., Maurer, M. C., Philippou, H.

“…Essentials The roles of β‐barrels 1 and 2 in factor XIII (FXIII) are currently unknown. FXIII truncations lacking β‐barrel 2, both β‐barrels, or full length…”
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An international study on the standardization of fibrin clot permeability measurement: methodological considerations and implications for healthy control values by PIETERS, M., UNDAS, A., MARCHI, R., DE MAAT, M. P. M., WEISEL, J. W., ARIËNS, R. A. S.

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Characterization of the I4399M variant of apolipoprotein(a): implications for altered prothrombotic properties of lipoprotein(a) by Scipione, C. A., McAiney, J. T., Simard, D. J., Bazzi, Z. A., Gemin, M., Romagnuolo, R., Macrae, F. L., Ariëns, R. A., Hegele, R. A., Auld, J., Gauld, J. W., Boffa, M. B., Koschinsky, M. L.

“…Essentials Elevated lipoproteinp(a) is an independent and causal risk factor for atherothrombotic diseases. rs3798220 (Ile/Met substitution in apo(a)…”
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Clot structure and fibrinolytic potential in patients with post thrombotic syndrome by Bouman, A.C, McPherson, H, Cheung, Y.W, ten Wolde, M, ten Cate, H, Ariëns, R.A.S, ten Cate-Hoek, A.J

“…Abstract Introduction Post-thrombotic syndrome (PTS) is a chronic sequel of deep vein thrombosis (DVT). The clot structure and fibrinolytic potential in PTS is…”
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