Search Results - "Argyle, D. J"

European consensus document on mast cell tumours in dogs and cats by Blackwood, L, Murphy, S, Buracco, P, De Vos, J. P, De Fornel‐Thibaud, P, Hirschberger, J, Kessler, M, Pastor, J, Ponce, F, Savary-Bataille, K, Argyle, D. J

“…In preparing this document the Authors aimed to pool current information on canine and feline mast cell disease. The information was gathered from…”
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Epithelial-mesenchymal transition as a fundamental mechanism underlying the cancer phenotype by Cervantes-Arias, A., Pang, L. Y., Argyle, D. J.

“…Epithelial–mesenchymal transition (EMT) is a complex process involved in embryonic development, wound healing and carcinogenesis. During this process,…”
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Development of a questionnaire assessing health‐related quality‐of‐life in dogs and cats with cancer by Lynch, S, Savary‐Bataille, K, Leeuw, B, Argyle, D. J

“…Health‐related quality‐of‐life (HRQoL) has been studied extensively in human medicine. There is currently no standard HRQoL evaluation for veterinary oncology…”
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Receptor tyrosine kinase inhibitors: molecularly targeted drugs for veterinary cancer therapy by Bavcar, S, Argyle, D. J

“…Tyrosine kinases (TKs) are key mediators of signalling pathways in cells. Located at the surface of the cell, within the cytoplasm or in the nucleous, TKs have…”
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Flow cytometric techniques for detection of candidate cancer stem cell subpopulations in canine tumour models by Blacking, T. M, Waterfall, M, Samuel, K, Argyle, D. J

“…The cancer stem cell (CSC) hypothesis proposes that tumour growth is maintained by a distinct subpopulation of ‘CSC’. This study applied flow cytometric…”
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Expression of epidermal growth factor receptor (EGFR) and Ki67 in feline oral squamous cell carcinomas (FOSCC) by Bergkvist, G.T, Argyle, D.J, Morrison, L, MacIntyre, N, Hayes, A, Yool, D.A

“…The aims of this study were to establish expression of epidermal growth factor receptor (EGFR) and Ki67 in 67 archived biopsy samples of feline oral squamous…”
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in vitro effects of piroxicam and meloxicam on canine cell lines by Knottenbelt, C, Chambers, G, Gault, E, Argyle, D.J

“…Objectives: To analyse the direct antiproliferative effects of both piroxicam and meloxicam at a variety of concentrations on a series of canine cancer cell…”
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Inflammation and cancer: Till death tears them apart by Raposo, T.P., Beirão, B.C.B., Pang, L.Y., Queiroga, F.L., Argyle, D.J.

“…•Inflammation plays a key role in cancer initiation and propagation.•Chronic and subclinical inflammation increases cancer risk.•Cytokines, chemokines and…”
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Telomerase: A Potential Diagnostic and Therapeutic Tool in Canine Oncology by Argyle, D. J., Nasir, L.

“…In recent years there has been considerable interest in telomerase as a target for therapeutic intervention in oncology. This largely stems from the vast…”
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Notch pathway inhibition targets chemoresistant insulinoma cancer stem cells by Capodanno, Y, Buishand, F O, Pang, L Y, Kirpensteijn, J, Mol, J A, Argyle, D J

“…Insulinomas (INS) are the most common neuroendocrine pancreatic tumours in humans and dogs. The long-term prognosis for malignant INS is still poor due to a…”
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Transcriptomic analysis by RNA sequencing characterises malignant progression of canine insulinoma from normal tissue to metastatic disease by Capodanno, Y., Buishand, F. O., Pang, L. Y., Kirpensteijn, J., Mol, J. A., Elders, R., Argyle, D. J.

“…Insulinomas (INS) are the most common human and canine functioning pancreatic neuroendocrine tumours. The long-term prognosis for malignant INS is poor,…”
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Histopathologic, Immunohistochemical, and Cytologic Analysis of Feline Myeloma-Related Disorders: Further Evidence for Primary Extramedullary Development in the Cat by Mellor, P.J, Haugland, S, Smith, K.C, Powell, R.M, Archer, J, Scase, T.J, Villiers, E.J, McNeil, P.E, Nixon, C, Knott, C, Fournier, D, Murphy, S, Polton, G.A, Belford, C, Philbey, A.W, Argyle, D.J, Herrtage, M.E, Day, M.J

“…Feline myeloma-related disorders (MRD) are rare neoplasms of plasma cells. The multistep transformation model of myeloma in humans is based on the premise that…”
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Telomerase reverse transcriptase (TERT) expression and proliferation in canine brain tumours by Long, S., Argyle, D. J., Nixon, C., Nicholson, I., Botteron, C., Olby, N., Platt, S., Smith, K., Rutteman, G. R., Grinwis, G. C. M., Nasir, L.

“…Telomerase is a ribonucleoprotein enzyme complex that synthesizes telomere DNA. It is detected in 85–90% of malignant tumours in humans, but not in most…”
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Antibiotic prophylaxis in veterinary cancer chemotherapy: A review and recommendations by Bisson, J. L., Argyle, D. J., Argyle, S. A.

“…Bacterial infection following cancer chemotherapy‐induced neutropenia is a serious cause of morbidity and mortality in human and veterinary patients…”
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Cohort study of COX-1 and COX-2 expression in canine rectal and bladder tumours by Knottenbelt, C., Mellor, D., Nixon, C., Thompson, H., Argyle, D. J.

“…Objectives: To determine the role that cyclooxygenase‐1 (COX‐1) and cyclooxygenase‐2 (COX‐2) play in malignant transformation in canine transitional cell…”
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Canine and feline lymphoma: challenges and opportunities for creating a paradigm shift by Argyle, D. J., Pecceu, E.

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Disease- and cell-type-specific transcriptional targeting of vectors for osteoarthritis gene therapy: further development of a clinical canine model by Campbell, S. E., Bennett, D., Nasir, L., Gault, E. A., Argyle, D. J.

“…Objectives. The potential for undesirable systemic effects related to constitutive expression of certain therapeutic transgenes may be limited through the…”
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Gene network and canonical pathway analysis in canine myxomatous mitral valve disease: A microarray study by Lu, C.-C., Liu, M.-M., Culshaw, G., Clinton, M., Argyle, D.J., Corcoran, B.M.

“…•Microarrays were used to analyse transcript changes in canine myxomatous mitral valve disease (MMVD).•In total, 591 differentially expressed genes were…”
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Combination toceranib and lomustine shows frequent high grade toxicities when used for treatment of non-resectable or recurrent mast cell tumours in dogs: A European multicentre study by Bavcar, S., de Vos, J., Kessler, M., de Fornel, P., Buracco, P., Murphy, S., Hirschberger, J., Argyle, D.J.

“…•Non-resectable, recurrent and/or metastatic mast cell tumours (MCTs) in dogs represent a clinical challenge.•Ten dogs with MCTs were treated with a…”
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Exploring new biomarkers in the tumour microenvironment of canine inflammatory mammary tumours by Raposo, T. P., Pires, I., Prada, J., Queiroga, F. L., Argyle, D. J.

“…Human inflammatory breast cancer (IBC) and canine inflammatory mammary cancer (CIMC) are the most aggressive forms of mammary cancer. Current research aims to…”
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