Search Results - "Argoud, Karène"

Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models by Nicholson, Jeremy K, Wallis, Robert H, Baunsgaard, Dorrit, Sidelmann, Ulla Grove, Keun, Hector C, Gauguier, Dominique, Barton, Richard H, D'Amato, Lisa, Dumas, Marc-Emmanuel, Blancher, Christine, Wilder, Steven P, Argoud, Karène, Bihoreau, Marie-Thérèse, Fearnside, Jane F, Scott, James

“…Characterizing the relationships between genomic and phenotypic variation is essential to understanding disease etiology. Information-dense data sets derived…”
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A modified RNA-Seq approach for whole genome sequencing of RNA viruses from faecal and blood samples by Batty, Elizabeth M, Wong, T H Nicholas, Trebes, Amy, Argoud, Karène, Attar, Moustafa, Buck, David, Ip, Camilla L C, Golubchik, Tanya, Cule, Madeleine, Bowden, Rory, Manganis, Charis, Klenerman, Paul, Barnes, Eleanor, Walker, A Sarah, Wyllie, David H, Wilson, Daniel J, Dingle, Kate E, Peto, Tim E A, Crook, Derrick W, Piazza, Paolo

“…To date, very large scale sequencing of many clinically important RNA viruses has been complicated by their high population molecular variation, which creates…”
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Untargeted Metabolome Quantitative Trait Locus Mapping Associates Variation in Urine Glycerate to Mutant Glycerate Kinase by Cazier, Jean-Baptise, Kaisaki, Pamela J, Argoud, Karène, Blaise, Benjamin J, Veselkov, Kirill, Ebbels, Timothy M. D, Tsang, Tsz, Wang, Yulan, Bihoreau, Marie-Thérèse, Mitchell, Steve C, Holmes, Elaine C, Lindon, John C, Scott, James, Nicholson, Jeremy K, Dumas, Marc-Emmanuel, Gauguier, Dominique

“…With successes of genome-wide association studies, molecular phenotyping systems are developed to identify genetically determined disease-associated…”
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Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression by Kaisaki, Pamela J, Otto, Georg W, Argoud, Karène, Collins, Stephan C, Wallis, Robert H, Wilder, Steven P, Yau, Anthony C Y, Hue, Christophe, Calderari, Sophie, Bihoreau, Marie-Thérèse, Cazier, Jean-Baptiste, Mott, Richard, Gauguier, Dominique

“…To test the impact of genetic heterogeneity on - and -mediated mechanisms of gene expression regulation, we profiled the transcriptome of adipose tissue in 20…”
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Genetic control of differential acetylation in diabetic rats by Kaisaki, Pamela J, Otto, Georg W, McGouran, Joanna F, Toubal, Amine, Argoud, Karène, Waller-Evans, Helen, Finlay, Clare, Caldérari, Sophie, Bihoreau, Marie-Thérèse, Kessler, Benedikt M, Gauguier, Dominique, Mott, Richard

“…Post-translational protein modifications such as acetylation have significant regulatory roles in metabolic processes, but their relationship to both variation…”
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Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series by Dumas, Marc-Emmanuel, Domange, Céline, Calderari, Sophie, Martínez, Andrea Rodríguez, Ayala, Rafael, Wilder, Steven P, Suárez-Zamorano, Nicolas, Collins, Stephan C, Wallis, Robert H, Gu, Quan, Wang, Yulan, Hue, Christophe, Otto, Georg W, Argoud, Karène, Navratil, Vincent, Mitchell, Steve C, Lindon, John C, Holmes, Elaine, Cazier, Jean-Baptiste, Nicholson, Jeremy K, Gauguier, Dominique

“…The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus occurs through complex organ-specific cellular mechanisms and…”
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Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome by Wallis, Robert H, Collins, Stephan C, Kaisaki, Pamela J, Argoud, Karène, Wilder, Steven P, Wallace, Karin J, Ria, Massimiliano, Ktorza, Alain, Rorsman, Patrik, Bihoreau, Marie-Thérèse, Gauguier, Dominique

“…Complex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models. We have…”
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Comparative analysis of methods for gene transcription profiling data derived from different microarray technologies in rat and mouse models of diabetes by Wilder, Steven P, Kaisaki, Pamela J, Argoud, Karène, Salhan, Anita, Ragoussis, Jiannis, Bihoreau, Marie-Thérèse, Gauguier, Dominique

“…Microarray technologies are widely used to quantify the abundance of transcripts corresponding to thousands of genes. To maximise the robustness of…”
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Chromosomal mapping of pancreatic islet morphological features and regulatory hormones in the spontaneously diabetic (Type 2) Goto-Kakizaki rat by Finlay, Clare, Argoud, Karène, Wilder, Steven P, Ouali, Fetta, Ktorza, Alain, Kaisaki, Pamela J, Gauguier, Dominique

“…Insulin resistance and altered endocrine pancreas function are central pathophysiological features of type 2 diabetes mellitus (T2DM). The Goto-Kakizaki (GK)…”
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Chromosomal Mapping of Quantitative Trait Loci Controlling Elastin Content in Rat Aorta by Gauguier, Dominique, Behmoaras, Jacques, Argoud, Karène, Wilder, Steven P, Pradines, Christelle, Bihoreau, Marie Thérèse, Osborne-Pellegrin, Mary, Jacob, Marie Paule

“…Extracellular matrix molecules such as elastin and collagens provide mechanical support to the vessel wall. In addition to its structural role, elastin is a…”
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Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics by Handel, Adam E, Chintawar, Satyan, Lalic, Tatjana, Whiteley, Emma, Vowles, Jane, Giustacchini, Alice, Argoud, Karene, Sopp, Paul, Nakanishi, Mahito, Bowden, Rory, Cowley, Sally, Newey, Sarah, Akerman, Colin, Ponting, Chris P, Cader, M Zameel

“…Induced pluripotent stem cell (iPSC)-derived cortical neurons potentially present a powerful new model to understand corticogenesis and neurological disease…”
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Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats by Collins, Stephan C, Wallis, Robert H, Wilder, Steven P, Wallace, Karin J, Argoud, Karène, Kaisaki, Pamela J, Bihoreau, Marie-Thérèse, Gauguier, Dominique

“…Genetic studies in experimental crosses derived from the inbred Goto-Kakizaki (GK) rat model of spontaneous diabetes mellitus have identified quantitative…”
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Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus by Hu, Yaomin, Kaisaki, Pamela J, Argoud, Karène, Wilder, Steven P, Wallace, Karin J, Woon, Peng Y, Blancher, Christine, Tarnow, Lise, Groop, Per-Henrik, Hadjadj, Samy, Marre, Michel, Parving, Hans-Henrik, Farrall, Martin, Cox, Roger D, Lathrop, Mark, Vionnet, Nathalie, Bihoreau, Marie-Thérèse, Gauguier, Dominique

“…Hyperglycaemia in diabetes mellitus (DM) alters gene expression regulation in various organs and contributes to long term vascular and renal complications. We…”
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Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q by Wallace, Karin J, Wallis, Robert H, Collins, Stephan C, Argoud, Karene, Kaisaki, Pamela J, Ktorza, Alain, Woon, Peng Y, Bihoreau, Marie-Therese, Gauguier, Dominique

“…1 The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom 2 Laboratoire de Physiopathologie de la Nutrition, Centre National…”
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Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains by Woon, Peng Y., Curtis, Anne M., Kaisaki, Pamela J., Argoud, Karène, Wallace, Karin J., Bihoreau, Marie-Thérèse, FitzGerald, Garret A., Gauguier, Dominique

“…While mutations in genes that function in the core molecular clock may disrupt circadian periodicity, their relevance to diurnal variation in metabolic,…”
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Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome by Wilder, Steven P, Bihoreau, Marie-Thérèse, Argoud, Karène, Watanabe, Takeshi K, Lathrop, Mark, Gauguier, Dominique

“…Inbred strains of the laboratory rat are widely used for identifying genetic regions involved in the control of complex quantitative phenotypes of biomedical…”
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Genetic Control of Differential Acetylation in Diabetic Rats: e94555 by Kaisaki, Pamela J, Otto, Georg W, McGouran, Joanna F, Toubal, Amine, Argoud, Karene, Waller-Evans, Helen, Finlay, Clare, Calderari, Sophie, Bihoreau, Marie-Therese, Kessler, Benedikt M

“…Post-translational protein modifications such as acetylation have significant regulatory roles in metabolic processes, but their relationship to both variation…”
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A Modified RNA-Seq Approach for Whole Genome Sequencing of RNA Viruses from Faecal and Blood Samples. e66129 by Batty, Elizabeth M, Wong, T HNicholas, Trebes, Amy, Argoud, Karene, Attar, Moustafa, Buck, David, Ip, Camilla LC, Golubchik, Tanya, Cule, Madeleine, Bowden, Rory

“…To date, very large scale sequencing of many clinically important RNA viruses has been complicated by their high population molecular variation, which creates…”
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