Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine

Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine

Despite the broad anti-microbial and anti-inflammatory properties of silver nanoparticles (AgNPs), their use in bioengineered corneal replacements or bandage contact lenses has been hindered due to their intense yellow coloration. In this communication, we report the development of a new strategy to...

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Bibliographic Details
Published in:Nanoscale Vol. 8; no. 12; p. 6484
Main Authors: Alarcon, E I, Vulesevic, B, Argawal, A, Ross, A, Bejjani, P, Podrebarac, J, Ravichandran, R, Phopase, J, Suuronen, E J, Griffith, M
Format: Journal Article
Language:English
Published: England 01-01-2016
Subjects:
Animals
Anti-Infective Agents - administration & dosage
Antimicrobial Cationic Peptides - chemistry
Biocompatible Materials
Collagen - chemistry
Cornea - surgery
Corneal Transplantation - instrumentation
Corneal Transplantation - methods
Hydrogels - chemistry
Interleukin-6 - metabolism
Lens, Crystalline - surgery
Materials Testing
Metal Nanoparticles - chemistry
Mice
Nanomedicine - methods
Regenerative Medicine - methods
Silver - chemistry
Stress, Mechanical
Tensile Strength
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Summary:Despite the broad anti-microbial and anti-inflammatory properties of silver nanoparticles (AgNPs), their use in bioengineered corneal replacements or bandage contact lenses has been hindered due to their intense yellow coloration. In this communication, we report the development of a new strategy to pre-stabilize and incorporate AgNPs with different colours into collagen matrices for fabrication of corneal implants and lenses, and assessed their in vitro and in vivo activity.
ISSN:2040-3372
DOI:10.1039/c6nr01339b