Search Results - "Arezzo, Joseph"

Long-Acting C-Peptide and Neuropathy in Type 1 Diabetes: A 12-Month Clinical Trial by Wahren, John, Foyt, Howard, Daniels, Mark, Arezzo, Joseph C

“…Lack of C-peptide in type 1 diabetes may be an important contributing factor in the development of microvascular complications. Replacement of native C-peptide…”
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Efficacy and safety of pregabalin 600 mg/d for treating painful diabetic peripheral neuropathy: a double-blind placebo-controlled trial by Arezzo, Joseph C, Rosenstock, Julio, Lamoreaux, Linda, Pauer, Lynne

“…Recent consensus guidelines recommend pregabalin as a first-tier treatment for painful diabetic peripheral neuropathy (DPN). We evaluated the efficacy of…”
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Diabetic polyneuropathies: update on research definition, diagnostic criteria and estimation of severity by Dyck, Peter J., Albers, James W., Andersen, Henning, Arezzo, Joseph C., Biessels, Geert-Jan, Bril, Vera, Feldman, Eva L., Litchy, William J., O'Brien, Peter C., Russell, James W.

“…Prior to a joint meeting of the Neurodiab Association and International Symposium on Diabetic Neuropathy held in Toronto, Ontario, Canada, 13‐18 October 2009,…”
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Use of Nerve Conduction Assessments to Evaluate Drug-Induced Peripheral Neuropathy in Nonclinical Species—A Brief Review by DaSilva, Jamie K., Arezzo, Joseph C.

“…The peripheral nervous system (PNS) is subject to a wide range of structural and functional insults including direct damage to axons, loss of myelin, and…”
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Neurotoxicity of an Hepatitis B Virus (HBV) Transcript Inhibitor in 13-Week Rat and Monkey Studies by Lake, April D, Holsapple, Kevin, McDonnell, Tanya, Arezzo, Joseph C, Ramirez, Ricardo, Gamelin, Lindsay, Yu, Mei, Glatt, Dylan, Dick, Ryan, Xie, Xiaodong, Choy, Regina, Cheng, Guofeng, Tay, Chin H, Chester, Anne, Kato, Darryl, Burns-Naas, Leigh Ann

“…Abstract The nonclinical safety profile of GS-8873, a hepatitis B virus RNA transcript inhibitor was evaluated in rat and monkey 13-week toxicity studies with…”
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Diabetic Neuropathies: A statement by the American Diabetes Association by Boulton, Andrew J.M, Vinik, Arthur I, Arezzo, Joseph C, Bril, Vera, Feldman, Eva L, Freeman, Roy, Malik, Rayaz A, Maser, Raelene E, Sosenko, Jay M, Ziegler, Dan

“…Boulton et al provide a relevant information on diabetic neuropathies, a heterogeneous, affecting different parts of the nervous system that present with…”
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Early uneven ear input induces long-lasting differences in left-right motor function by Antoine, Michelle W, Zhu, Xiaoxia, Dieterich, Marianne, Brandt, Thomas, Vijayakumar, Sarath, McKeehan, Nicholas, Arezzo, Joseph C, Zukin, R Suzanne, Borkholder, David A, Jones, Sherri M, Frisina, Robert D, Hébert, Jean M

“…How asymmetries in motor behavior become established normally or atypically in mammals remains unclear. An established model for motor asymmetry that is…”
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Diabetic somatic neuropathies by BOULTON, Andrew J. M, MALIK, Rayaz A, AREZZO, Joseph C, SOSENKO, Jay M

“…The neuropathies are among the most common of the long-term complications of diabetes, characterized by a progressive loss of nerve fibers, which may affect…”
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NeuroBloc ®/Myobloc ®: Unique features and findings by Arezzo, Joseph C.

“…This review outlines factors that differentiate botulinum toxin serotypes and focuses on the unique features of the commercially available form of BoNT-B…”
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Drug safety is a barrier to the discovery and development of new androgen receptor antagonists by Foster, William R., Car, Bruce D., Shi, Hong, Levesque, Paul C., Obermeier, Mary T., Gan, Jinping, Arezzo, Joseph C., Powlin, Stephanie S., Dinchuk, Joseph E., Balog, Aaron, Salvati, Mark E., Attar, Ricardo M., Gottardis, Marco M.

“…BACKGROUND Androgen receptor (AR) antagonists are part of the standard of care for prostate cancer. Despite the almost inevitable development of resistance in…”
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A Causative Link Between Inner Ear Defects and Long-Term Striatal Dysfunction by Antoine, Michelle W., Hübner, Christian A, Arezzo, Joseph C., Hébert, Jean M.

“…There is a high prevalence of behavioral disorders that feature hyperactivity in individuals with severe inner ear dysfunction. What remains unknown is whether…”
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Neuropathy associated with microtubule inhibitors: diagnosis, incidence, and management by Swain, Sandra M, Arezzo, Joseph C

“…Microtubule inhibitor (MTI)-based chemotherapies used in the treatment of breast cancer--including vinca alkaloids, taxanes, and epothilones--are known to be…”
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The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity by Wieczorek, Michal, Tcherkezian, Joseph, Bernier, Cynthia, Prota, Andrea E, Chaaban, Sami, Rolland, Yannève, Godbout, Claude, Hancock, Mark A, Arezzo, Joseph C, Ocal, Ozhan, Rocha, Cecilia, Olieric, Natacha, Hall, Anita, Ding, Hui, Bramoullé, Alexandre, Annis, Matthew G, Zogopoulos, George, Harran, Patrick G, Wilkie, Thomas M, Brekken, Rolf A, Siegel, Peter M, Steinmetz, Michel O, Shore, Gordon C, Brouhard, Gary J, Roulston, Anne

“…Microtubule-targeting agents (MTAs) are widely used anticancer agents, but toxicities such as neuropathy limit their clinical use. MTAs bind to and alter the…”
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Spectrotemporal Analysis of Evoked and Induced Electroencephalographic Responses in Primary Auditory Cortex (A1) of the Awake Monkey by Steinschneider, Mitchell, Fishman, Yonatan I., Arezzo, Joseph C.

“…Electroencephalography is increasingly being used to probe the functional organization of auditory cortex. Modulation of the electroencephalographic (EEG)…”
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Auditory stream segregation in monkey auditory cortex: effects of frequency separation, presentation rate, and tone duration by FISHMAN, Yonatan I, AREZZO, Joseph C, STEINSCHNEIDER, Mitchell

“…Auditory stream segregation refers to the organization of sequential sounds into "perceptual streams" reflecting individual environmental sound sources. In the…”
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EEG: Characteristics of drug-induced seizures in rats, dogs and non-human primates by Authier, Simon, Arezzo, Joseph, Pouliot, Mylène, Accardi, Michael V., Boulay, Emmanuel, Troncy, Eric, Dubuc Mageau, Michelle, Tan, Wendy, Sanfacon, Audrey, Mignault Goulet, Stephanie, Paquette, Dominique

“…Seizures are amongst the most frequent neurological issues encountered in pre-clinical safety testing. The objective was to characterize EEG morphologies and…”
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Possible Mechanisms for the Effects of Botulinum Toxin on Pain by Arezzo, Joseph C

“…The therapeutic effects of botulinum toxin are principally, if not exclusively, derived from an alteration in the release of acetylcholine (ACh) at…”
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Lenalidomide for complex regional pain syndrome type 1: lack of efficacy in a phase II randomized study by Manning, Donald C, Alexander, Guillermo, Arezzo, Joseph C, Cooper, Alyse, Harden, R Norman, Oaklander, Anne Louise, Raja, Srinivasa N, Rauck, Richard, Schwartzman, Robert

“…Complex regional pain syndrome (CRPS) is a potentially debilitating chronic pain syndrome with a poorly understood but likely neuroimmune/multifactorial…”
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Reprint of "EEG: Characteristics of drug-induced seizures in rats, dogs and non-human primates" by Authier, Simon, Arezzo, Joseph, Pouliot, Mylène, Accardi, Michael V., Boulay, Emmanuel, Troncy, Eric, Dubuc Mageau, Michelle, Tan, Wendy, Sanfacon, Audrey, Mignault Goulet, Stephanie, Paquette, Dominique

“…Seizures are amongst the most frequent neurological issues encountered in pre-clinical safety testing. The objective was to characterize EEG morphologies and…”
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Low Peripheral Nerve Conduction Velocities and Amplitudes Are Strongly Related to Diabetic Microvascular Complications in Type 1 Diabetes: The EURODIAB Prospective Complications Study by Charles, Morten, Soedamah-Muthu, Sabita S, Tesfaye, Solomon, Fuller, John H, Arezzo, Joseph C, Chaturvedi, Nishi, Witte, Daniel R

“…OBJECTIVE: Slow nerve conduction velocity and reduction in response amplitude are objective hallmarks of diabetic sensorimotor polyneuropathy. Because…”
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