Search Results - "Areso, Pilar"

The ever changing moods of calmodulin: how structural plasticity entails transductional adaptability by Villarroel, Alvaro, Taglialatela, Maurizio, Bernardo-Seisdedos, Ganeko, Alaimo, Alessandro, Agirre, Jon, Alberdi, Araitz, Gomis-Perez, Carolina, Soldovieri, Maria Virginia, Ambrosino, Paolo, Malo, Covadonga, Areso, Pilar

“…The exceptional versatility of calmodulin (CaM) three-dimensional arrangement is reflected in the growing number of structural models of CaM/protein complexes…”
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Pivoting between calmodulin lobes triggered by calcium in the Kv7.2/calmodulin complex by Alaimo, Alessandro, Alberdi, Araitz, Gomis-Perez, Carolina, Fernández-Orth, Juncal, Bernardo-Seisdedos, Ganeko, Malo, Covadonga, Millet, Oscar, Areso, Pilar, Villarroel, Alvaro

“…Kv7.2 (KCNQ2) is the principal molecular component of the slow voltage gated M-channel, which strongly influences neuronal excitability. Calmodulin (CaM) binds…”
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Differential Regulation of PI(4,5)P2 Sensitivity of Kv7.2 and Kv7.3 Channels by Calmodulin by Gomis-Perez, Carolina, Soldovieri, Maria V., Malo, Covadonga, Ambrosino, Paolo, Taglialatela, Maurizio, Areso, Pilar, Villarroel, Alvaro

“…The identification and understanding of critical factors regulating M-current functional density, whose main components are Kv7.2 and Kv7.3 subunits, has…”
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Calmodulin Activation Limits the Rate of KCNQ2 K+ Channel Exit from the Endoplasmic Reticulum by Alaimo, Alessandro, Gómez-Posada, Juan Camilo, Aivar, Paloma, Etxeberría, Ainhoa, Rodriguez-Alfaro, Jose Angel, Areso, Pilar, Villarroel, Alvaro

“…The potential regulation of protein trafficking by calmodulin (CaM) is a novel concept that remains to be substantiated. We proposed that KCNQ2 K+ channel…”
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Kv7 channels can function without constitutive calmodulin tethering by Gómez-Posada, Juan Camilo, Aivar, Paloma, Alberdi, Araitz, Alaimo, Alessandro, Etxeberría, Ainhoa, Fernández-Orth, Juncal, Zamalloa, Teresa, Roura-Ferrer, Meritxell, Villace, Patricia, Areso, Pilar, Casis, Oscar, Villarroel, Alvaro

“…M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding…”
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Surface expression and subunit specific control of steady protein levels by the Kv7.2 helix A-B linker by Aivar, Paloma, Fernández-Orth, Juncal, Gomis-Perez, Carolina, Alberdi, Araitz, Alaimo, Alessandro, Rodríguez, Manuel S, Giraldez, Teresa, Miranda, Pablo, Areso, Pilar, Villarroel, Alvaro

“…Kv7.2 and Kv7.3 are the main components of the neuronal voltage-dependent M-current, which is a subthreshold potassium conductance that exerts an important…”
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Expression of glutamate transporters in rat optic nerve oligodendrocytes by Domercq, María, Sánchez-Gómez, María Victoria, Areso, Pilar, Matute, Carlos

“…To investigate the role of glutamate transport in non‐synaptic glia, we characterized the expression of three major glutamate transporters (EAAC1, GLAST and…”
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Uncoupling PIP2-calmodulin regulation of Kv7.2 channels by an assembly destabilizing epileptogenic mutation by Alberdi, Araitz, Gomis-Perez, Carolina, Bernardo-Seisdedos, Ganeko, Alaimo, Alessandro, Malo, Covadonga, Aldaregia, Juncal, Lopez-Robles, Carlos, Areso, Pilar, Butz, Elisabeth, Wahl-Schott, Christian, Villarroel, Alvaro

“…We show that the combination of an intracellular bi-partite calmodulin (CaM)-binding site and a distant assembly region affect how an ion channel is regulated…”
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Monitoring Structural Reorganization of Calmodulin in Complex with the C-Terminus of KCNQ Channels by Gomis-Perez, Carolina, Nunez-Viadero, Eider, Bernardo-Seisdedos, Ganeko, Malo, Covadonga, Areso, Pilar, Villarroel, Alvaro

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Structural Insights of the Calcium Mediated Reorganization of the Calmodulin/Kv7.2 Channel Complex by Villarroel, Alvaro, Bernardo-Seisdedos, Ganeko, Alaimo, Alessandro, Gomis-Perez, Carolina, Alberdi, Araitz, Malo, Covadonga, Areso, Pilar, Millet, Oscar

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Calmodulin Binding to a Novel Site in the AB Module of Kv7.2 Subunits Regulates Surface Expression by Bernardo-Seisdedos, Ganeko, Fernandez-Orth, Juncal, Gomis-Perez, Carolina, Alaimo, Alessandro, Alberdi, Araitz, Malo, Covadonga, Areso, Pilar, Villarroel, Alvaro

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Differential Regulation of PI(4,5)P 2 Sensitivity of Kv7.2 and Kv7.3 Channels by Calmodulin by Gomis-Perez, Carolina, Soldovieri, Maria V, Malo, Covadonga, Ambrosino, Paolo, Taglialatela, Maurizio, Areso, Pilar, Villarroel, Alvaro

“…- Calmodulin-dependent Kv7.2 current density without the need of binding calcium.- Kv7.2 current density increase is accompanied with resistance to PI(4,5)P…”
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Anomalous Calcium Dependent Binding of Calmodulin to KCNQ2 Potassium Channels by Alaimo, Alessandro, Areso, Pilar, Villarroel, Alvaro

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Cooperativity between calmodulin-binding sites in Kv7.2 channels by Alaimo, Alessandro, Alberdi, Araitz, Gomis-Perez, Carolina, Fernández-Orth, Juncal, Gómez-Posada, Juan Camilo, Areso, Pilar, Villarroel, Alvaro

“…Among the multiple roles assigned to calmodulin (CaM), controlling the surface expression of Kv7.2 channels by binding to two discontinuous sites is a unique…”
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An unconventional calmodulin-anchoring site within the AB module of Kv7.2 channels by Gomis-Perez, Carolina, Alaimo, Alessandro, Fernandez-Orth, Juncal, Alberdi, Araitz, Aivar-Mateo, Paloma, Bernardo-Seisdedos, Ganeko, Malo, Covadonga, Areso, Pilar, Felipe, Antonio, Villarroel, Alvaro

“…Calmodulin (CaM) binding to the AB module is crucial for multiple mechanisms governing the function of Kv7.2 (also known as KCNQ2) K(+) channel subunits, which…”
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Calcium-Independent Potentation of Kv7.2 Current Density by Calmodulin by Gomis-Perez, Carolina, Soldovieri, Virginia, Alberdi, Araitz, Ambrosino, Paolo, Alaimo, Alessandro, Bernardo-Seisdedos, Ganeko, Areso, Pilar, Taglialatela, Maurizio, Villarroel, Alvaro

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PIP2 and Surface Expression Underlie Apo-Calmodulin Dependent Kv7.2/KCNQ2 Current Potentiation by Gomis-Perez, Carolina, Soldovieri, Maria Virginia, Alberdi, Araitz, Ambrosino, Paolo, Di Maria, Michela, Alaimo, Alessandro, Bernardo-Seisdedos, Ganeko, Malo, Covadonga, Areso, Pilar, Taglialatela, Maurizio, Villarroel, Alvaro

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Disruption of Assembly/Calmodulin-Binding Coupling and Calmodulin-Dependent Potentiation of Kv7.2 Channels by a Epileptogenic Helix D Mutation by Alberdi, Araitz, Bernardo-Seisdedos, Ganeko, Gomis-Perez, Carolina, Alaimo, Alessandro, Malo, Covadonga, Butz, Elisabeth, Wahl-Schott, Christian, Areso, Pilar, Villarroel, Alvaro

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Calmodulin regulates the trafficking of KCNQ2 potassium channels by Etxeberria, Ainhoa, Aivar, Paloma, Rodriguez-Alfaro, Jose Angel, Alaimo, Alessandro, Villacé, Patricia, Gómez-Posada, Juan Camilo, Areso, Pilar, Villarroel, Alvaro

“…Voltage-dependent potassium KCNQ2 (Kv7.2) channels play a prominent role in the control of neuronal excitability. These channels must associate with calmodulin…”
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Pivoting between Calmodulin Lobes in the Calmodulin/Kv7.2 Complex Triggered by Calcium by Villarroel, Alvaro, Alaimo, Alessandro, Alberdi, Araitz, Gomis-Perez, Carolina, Fernandez-Orh, Juncal, Bernardo-Seisdedos, Ganeko, Oscar, Millet, Areso, Pilar

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