Search Results - "Arensdorf, Patrick"
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A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation
Published in Nature communications (02-12-2020)“…DNA 5-hydroxymethylcytosine (5hmC) modification is known to be associated with gene transcription and frequently used as a mark to investigate dynamic DNA…”
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Consensus molecular subtypes and orphan non-coding RNAs in colorectal cancer
Published in Journal of clinical oncology (01-06-2023)“…e15651 Background: Colorectal cancer (CRC) is a highly heterogeneous disease with variable response to different treatment strategies. The consensus molecular…”
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Detection of early-stage cancers using circulating orphan non-coding RNAs in blood
Published in Journal of clinical oncology (01-06-2023)“…3051 Background: Orphan non-coding RNAs (oncRNAs) are a novel category of small RNAs (smRNAs) that are present in tumors and largely absent in healthy tissue…”
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Deep generative AI models analyzing circulating orphan non-coding RNAs enable detection of early-stage lung cancer
Published in Nature communications (21-11-2024)“…Liquid biopsies have the potential to revolutionize cancer care through non-invasive early detection of tumors. Developing a robust liquid biopsy test requires…”
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Abstract 3353: Discovery and validation of orphan noncoding RNA profiles across multiple cancers in TCGA and two independent cohorts
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Small non-coding RNAs (sncRNAs) have established roles as post-transcriptional regulators of cancer pathogenesis. We recently reported a novel and previously…”
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Abstract PO2-13-08: Cell-free orphan noncoding RNAs and AI enable early detection of invasive breast cancer and ductal carcinoma in-situ
Published in Cancer research (Chicago, Ill.) (02-05-2024)“…Background Earlier detection of breast cancer through mammography screening has reduced disease-specific mortality; however, confounding issues such as…”
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Abstract P1-05-18: Orphan non-coding RNAs for early detection of breast cancer with liquid biopsy
Published in Cancer research (Chicago, Ill.) (01-03-2023)“…Background: Early detection of breast cancer is crucial for optimal patient outcomes but cannot always be accomplished based on symptoms or screening…”
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Abstract 3678: Beyond detection: AI-based classification of breast cancer invasiveness using cell-free orphan non-coding RNAs
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Background: Approximately 1 in 8 women will be impacted by breast cancer in their lifetimes. Earlier detection of breast cancer through screening has improved…”
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Abstract 5711: Blood-based early detection of non-small cell lung cancer using orphan noncoding RNAs
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Background: Orphan non-coding RNAs (oncRNAs) are a novel category of small non-coding RNAs that are present in the tumor tissue and blood of people with cancer…”
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