Search Results - "Arends, Mark J."

Molecular pathology of Lynch syndrome by Cerretelli, Guia, Ager, Ann, Arends, Mark J, Frayling, Ian M

“…Lynch syndrome (LS) is characterised by predisposition to colorectal, endometrial, and other cancers and is caused by inherited pathogenic variants affecting…”
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Molecular pathological classification of colorectal cancer by Müller, Mike F., Ibrahim, Ashraf E. K., Arends, Mark J.

“…Colorectal cancer (CRC) shows variable underlying molecular changes with two major mechanisms of genetic instability: chromosomal instability and…”
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Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen by Pontel, Lucas B., Rosado, Ivan V., Burgos-Barragan, Guillermo, Garaycoechea, Juan I., Yu, Rui, Arends, Mark J., Chandrasekaran, Gayathri, Broecker, Verena, Wei, Wei, Liu, Limin, Swenberg, James A., Crossan, Gerry P., Patel, Ketan J.

“…Endogenous formaldehyde is produced by numerous biochemical pathways fundamental to life, and it can crosslink both DNA and proteins. However, the consequences…”
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Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen by Pham, Tu Anh N., Clare, Simon, Goulding, David, Arasteh, Julia M., Stares, Mark D., Browne, Hilary P., Keane, Jacqueline A., Page, Andrew J., Kumasaka, Natsuhiko, Kane, Leanne, Mottram, Lynda, Harcourt, Katherine, Hale, Christine, Arends, Mark J., Gaffney, Daniel J., Dougan, Gordon, Lawley, Trevor D.

“…Our intestinal microbiota harbors a diverse microbial community, often containing opportunistic bacteria with virulence potential. However, mutualistic…”
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Expression Atlas update: gene and protein expression in multiple species by Moreno, Pablo, Fexova, Silvie, George, Nancy, Manning, Jonathan R, Miao, Zhichiao, Mohammed, Suhaib, Muñoz-Pomer, Alfonso, Fullgrabe, Anja, Bi, Yalan, Bush, Natassja, Iqbal, Haider, Kumbham, Upendra, Solovyev, Andrey, Zhao, Lingyun, Prakash, Ananth, García-Seisdedos, David, Kundu, Deepti J, Wang, Shengbo, Walzer, Mathias, Clarke, Laura, Osumi-Sutherland, David, Tello-Ruiz, Marcela Karey, Kumari, Sunita, Ware, Doreen, Eliasova, Jana, Arends, Mark J, Nawijn, Martijn C, Meyer, Kerstin, Burdett, Tony, Marioni, John, Teichmann, Sarah, Vizcaíno, Juan Antonio, Brazma, Alvis, Papatheodorou, Irene

“…Abstract The EMBL-EBI Expression Atlas is an added value knowledge base that enables researchers to answer the question of where (tissue, organism part,…”
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Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice by Langevin, Frédéric, Crossan, Gerry P., Rosado, Ivan V., Arends, Mark J., Patel, Ketan J.

“…Reactive aldehydes are common carcinogens. They are also by-products of several metabolic pathways and, without enzymatic catabolism, may accumulate and cause…”
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MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype by Sodir, Nicole M, Kortlever, Roderik M, Barthet, Valentin J A, Campos, Tania, Pellegrinet, Luca, Kupczak, Steven, Anastasiou, Panayiotis, Swigart, Lamorna Brown, Soucek, Laura, Arends, Mark J, Littlewood, Trevor D, Evan, Gerard I

“…The signature features of pancreatic ductal adenocarcinoma (PDAC) are its fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that…”
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Lynch syndrome – cancer pathways, heterogeneity and immune escape by Seth, Sidhant, Ager, Ann, Arends, Mark J, Frayling, Ian M

“…Recent work has provided evidence for genetic and molecular heterogeneity in colorectal cancers (CRCs) arising in patients with Lynch syndrome (LS), dividing…”
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DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome by Poulogiannis, George, Frayling, Ian M, Arends, Mark J

“…Poulogiannis G, Frayling I M & Arends M J
(2010) Histopathology56, 167–179 DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome DNA…”
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Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma by Wong, Kim, van der Weyden, Louise, Schott, Courtney R., Foote, Alastair, Constantino-Casas, Fernando, Smith, Sionagh, Dobson, Jane M., Murchison, Elizabeth P., Wu, Hong, Yeh, Iwei, Fullen, Douglas R., Joseph, Nancy, Bastian, Boris C., Patel, Rajiv M., Martincorena, Inigo, Robles-Espinoza, Carla Daniela, Iyer, Vivek, Kuijjer, Marieke L., Arends, Mark J., Brenn, Thomas, Harms, Paul W., Wood, Geoffrey A., Adams, David J.

“…Mucosal melanoma is a rare and poorly characterized subtype of human melanoma. Here we perform a cross-species analysis by sequencing tumor-germline pairs from…”
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Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency by Kuijpers, Taco W., MD, PhD, Tool, Anton T.J., PhD, van der Bijl, Ivo, de Boer, Martin, van Houdt, Michel, de Cuyper, Iris M, Roos, Dirk, PhD, van Alphen, Floris, van Leeuwen, Karin, Cambridge, Emma L, Arends, Mark J., MBChB(Hons), PhD, MRCPath, Dougan, Gordon, PhD, Clare, Simon, PhD, Ramirez-Solis, Ramiro, PhD, Pals, Steven T., MD, PhD, Adams, David J., PhD, Meijer, Alexander B., PhD, van den Berg, Timo K., PhD

“…Arp2/3 gene deletions result in embryonic lethality in the mouse.2 The genetic defects in the regulatory proteins for cytoskeletal rearrangements cause…”
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BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model by Perna, Daniele, Karreth, Florian A., Rust, Alistair G., Perez-Mancera, Pedro A., Rashid, Mamunur, Iorio, Francesco, Alifrangis, Constantine, Arends, Mark J., Bosenberg, Marcus W., Bollag, Gideon, Tuveson, David A., Adams, David J.

“…BRAF (v-raf murine sarcoma viral oncogene homolog B) inhibitors elicit a transient anti-tumor response in ∼80% of BRAF ⱽ⁶⁰⁰-mutant melanoma patients that…”
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Primordial germ cell DNA demethylation and development require DNA translesion synthesis by Shah, Pranay, Hill, Ross, Dion, Camille, Clark, Stephen J., Abakir, Abdulkadir, Willems, Jeroen, Arends, Mark J., Garaycoechea, Juan I., Leitch, Harry G., Reik, Wolf, Crossan, Gerry P.

“…Mutations in DNA damage response (DDR) factors are associated with human infertility, which affects up to 15% of the population. The DDR is required during…”
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PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice by Poulogiannis, George, McIntyre, Rebecca E., Dimitriadi, Maria, Apps, John R., Wilson, Catherine H., Ichimura, Koichi, Luo, Feijun, Cantley, Lewis C., Wyllie, Andrew H., Adams, David J., Arends, Mark J.

“…In 100 primary colorectal carcinomas, we demonstrate by array comparative genomic hybridization (aCGH) that 33% show DNA copy number (DCN) loss involving…”
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Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome by Finch, Andrew J, Hilcenko, Christine, Basse, Nicolas, Drynan, Lesley F, Goyenechea, Beatriz, Menne, Tobias F, González Fernández, Africa, Simpson, Paul, D'Santos, Clive S, Arends, Mark J, Donadieu, Jean, Bellanné-Chantelot, Christine, Costanzo, Michael, Boone, Charles, McKenzie, Andrew N, Freund, Stefan M V, Warren, Alan J

“…Removal of the assembly factor eukaryotic initiation factor 6 (eIF6) is critical for late cytoplasmic maturation of 60S ribosomal subunits. In mammalian cells,…”
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Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution by Sodir, Nicole M., Pellegrinet, Luca, Kortlever, Roderik M., Campos, Tania, Kwon, Yong-Won, Kim, Shinseog, Garcia, Daniel, Perfetto, Alessandra, Anastasiou, Panayiotis, Swigart, Lamorna Brown, Arends, Mark J., Littlewood, Trevor D., Evan, Gerard I.

“…Germ-line hypomorphism of the pleiotropic transcription factor Myc in mice, either through Myc gene haploinsufficiency or deletion of Myc enhancers, delays…”
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Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch Syndrome model with Aldh1b1 inactivation by Cerretelli, Guia, Zhou, Ying, Müller, Mike F, Adams, David J, Arends, Mark J

“…Defective mismatch repair (dMMR) interacts with acetaldehyde, in a gene/environment interaction, enhancing dMMR-driven colonic tumour formation in a Lynch…”
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Mouse models of colorectal cancer as preclinical models by McIntyre, Rebecca E, Buczacki, Simon J.A, Arends, Mark J, Adams, David J

“…In this review, we discuss the application of mouse models to the identification and pre‐clinical validation of novel therapeutic targets in colorectal cancer,…”
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Mutational Analysis Identifies Therapeutic Biomarkers in Inflammatory Bowel Disease-Associated Colorectal Cancers by Din, Shahida, Wong, Kim, Mueller, Mike F, Oniscu, Anca, Hewinson, James, Black, Catherine J, Miller, Martin L, Jiménez-Sánchez, Alejandro, Rabbie, Roy, Rashid, Mamunar, Satsangi, Jack, Adams, David J, Arends, Mark J

“…Inflammatory bowel disease-associated colorectal cancers (IBD-CRC) are associated with a higher mortality than sporadic colorectal cancers. The poorly defined…”
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Signatures of adaptation in human invasive Salmonella Typhimurium ST313 populations from sub-Saharan Africa by Okoro, Chinyere K, Barquist, Lars, Connor, Thomas R, Harris, Simon R, Clare, Simon, Stevens, Mark P, Arends, Mark J, Hale, Christine, Kane, Leanne, Pickard, Derek J, Hill, Jennifer, Harcourt, Katherine, Parkhill, Julian, Dougan, Gordon, Kingsley, Robert A

“…Two lineages of Salmonella enterica serovar Typhimurium (S. Typhimurium) of multi-locus sequence type ST313 have been linked with the emergence of invasive…”
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