Search Results - "Arends, Jan–Willem"

Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability by Hermsen, Mario, Postma, Cindy, Baak, Jan, Weiss, Marjan, Rapallo, Anna, Sciutto, Andrea, Roemen, Guido, Arends, Jan–Willem, Williams, Richard, Giaretti, Walter, de Goeij, Anton, Meijer, Gerrit

“…Background & Aims: Current models of colorectal adenoma to carcinoma progression do not fully reflect the genetic heterogeneity and complexity of the disease…”
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A Large Non-immunized Human Fab Fragment Phage Library That Permits Rapid Isolation and Kinetic Analysis of High Affinity Antibodies by de Haard, H J, van Neer, N, Reurs, A, Hufton, S E, Roovers, R C, Henderikx, P, de Bruïne, A P, Arends, J W, Hoogenboom, H R

“…We report the design, construction, and use of the first very large non-immunized phage antibody library in Fab format, which allows the rapid isolation and…”
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Target validation for genomics using peptide‐specific phage antibodies: A study of five gene products overexpressed in colorectal cancer by van Beijnum, Judy R., Moerkerk, Peter T.M., Gerbers, Andrea J., de Bruïne, Adriaan P., Arends, Jan‐Willem, Hoogenboom, Hennie R., Hufton, Simon E.

“…Genomic approaches are providing a wealth of information on differential gene expression in cancer. To identify the most interesting genes amongst the many…”
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K-ras mutations and RASSF1A promoter methylation in colorectal cancer by VAN ENGELAND, Manon, ROEMEN, Guido M. J. M, BRINK, Mirian, PACHEN, Marco M. M, WEIJENBERG, Matty P, DE BRUÏNE, Adriaan P, ARENDS, Jan-Willem, VAN DEN BRANDT, Piet A, DE GOEIJ, Anton F. P. M, HERMAN, James G

“…Human cancer is characterized by genetic and epigenetic alterations. In this study we provide evidence for the interruption of Ras signaling in sporadic…”
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A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization by Hufton, Simon E., Moerkerk, Peter T., Brandwijk, Ricardo, de Bruïne, Adriaan P., Arends, Jan-Willem, Hoogenboom, Hennie R.

“…As a step towards understanding the complex differences between normal cells and cancer cells, we have used suppression subtractive hybridization (SSH) to…”
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TENASCIN AND FIBRONECTIN EXPRESSION IN HEALING HUMAN MYOCARDIAL SCARS by WILLEMS, INGRID E. M. G., ARENDS, JAN-WILLEM, DAEMEN, MAT J. A. P.

“…Fibronectin and tenascin are matrix proteins known to be present in early experimental wound healing. As only limited data are available regarding early matrix…”
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Antibody phage display technology and its applications by Hoogenboom, H R, de Bruïne, A P, Hufton, S E, Hoet, R M, Arends, J W, Roovers, R C

“…In recent years, the use of display vectors and in vitro selection technologies has transformed the way in which we generate ligands, such as antibodies and…”
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Gut Permeability, Intestinal Morphology, and Nutritional Depletion by Van Der Hulst, René R.W.J, Von Meyenfeldt, Maarten F, Van Kreel, Bernard K, Thunnissen, Frederik B.J.M, Brummer, Robert-Jan M, Arends, Jan-Willem, Soeters, Peter B

“…Nutritional depletion increases the risk for postoperative complications. The intestinal barrier may be important in the underlying pathophysiologic mechanism…”
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A sensitive immunoassay for rat fatty acid translocase (CD36) using phage antibodies selected on cell transfectants: abundant presence of fatty acid translocase/CD36 in cardiac and red skeletal muscle and up-regulation in diabetes by Pelsers, M M, Lutgerink, J T, Nieuwenhoven, F A, Tandon, N N, van der Vusse, G J, Arends, J W, Hoogenboom, H R, Glatz, J F

“…The rat membrane protein fatty acid translocase (FAT), which shows sequence similarity to human CD36 (a membrane protein supposedly involved in a variety of…”
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Evidence for a bias toward intracellular antigens in the local humoral anti‐tumor immune response of a colorectal cancer patient revealed by phage display by Roovers, Rob C., van der Linden, Edith, Zijlema, Han, de Bruïne, Adriaan, Arends, Jan‐Willem, Hoogenboom, Hennie R.

“…Many patients with colorectal carcinoma (CRC) mount a cellular as well as a humoral immune response to the tumor. To investigate the nature and specificity of…”
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Surface exposure of phosphatidylserine during apoptosis of rat thymocytes precedes nuclear changes by Stuart, Marc C.A., Damoiseaux, Jan G.M.C., Frederik, Peter M., Arends, Jan-Willem, Reutelingsperger, Chris P.M.

“…Cell surface exposure of phosphatidylserine (PS) during apoptosis serves recognition and removal of the dying cell by phagocytes. Loss of phospholipid…”
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Microvessel density in unknown primary tumors by Hillen, Harry F.P., Hak, Liesbeth E., Joosten‐Achjanie, Suzanne R., Arends, Jan‐Willem

“…Unknown primary tumors (UPT) are characterized by early and widespread metastasis. There is a strong indication that angiogenesis measured as microvessel…”
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Transforming Growth Factor‐Beta and bcl‐2 Distribution Patterns Distinguish Trichoepithelioma from Basal Cell Carcinoma by VERHAEGH, MARC E.J.M., ARENDS, JAN‐WILLEM, MAJOIE, I.M. LEONIE, HOEKZEMA, RICK, NEUMANN, H.A. MARTINO

“…background Trichoepithelioma (TE) and basal cell carcinoma (BCC) have many features in common both clinically and histologically. Despite these many…”
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Patterns of α- and β-catenin and E-cadherin expression in colorectal adenomas and carcinomas by Van Der Wurff, Anna A. M., Vermeulen, Stefan J. T., Van Der Linden, Edith P. M., Mareel, Marc M., Bosman, Fred T., Arends, Jan-Willem

“…Previous in vitro and in vivo model studies have shown that when E‐cadherin expression in carcinoma cells is reduced, invasive behaviour ensues. The situation…”
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Cell turnover parameters in small and large cell varieties of primary intestinal non‐hodgkin's lymphoma by Gisbertz, Ingrid A. M., Schouten, Harry C., Bot, Fredrik J, Arends, Jan‐Willem

“…BACKGROUND In contrast to primary gastric lymphoma, primary intestinal lymphoma is an uncommon condition with a poorer outcome, perhaps due to differences in…”
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Somatostatin displayed on filamentous phage as a receptor‐specific agonist by Rousch, Mat, Lutgerink, Jan T, Coote, James, Bruïne, Adriaan, Arends, Jan‐Willem, Hoogenboom, Hennie R

“…1 In search of methods to identify bio‐active ligands specific for G protein‐coupled receptors with seven transmembrane spanning regions, we have developed a…”
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Factors influencing noncompliance and contamination in a randomized trial of "Western" (r1) versus "Japanese" (r2) type surgery in gastric cancer by Bunt, T M, Bonenkamp, H J, Hermans, J, van de Velde, C J, Arends, J W, Fleuren, G, Bruijn, J A

“…A randomized trial was undertaken comparing the Western R1 resection with limited N1-level lymphadenectomy and the Japanese R2 resection with extended…”
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Isolation of human antibodies to tumor-associated endothelial cell markers by in vitro human endothelial cell selection with phage display libraries by Mutuberria, Ricardo, Satijn, Sietske, Huijbers, Angelique, van der Linden, Edith, Lichtenbeld, Hera, Chames, Patrick, Arends, Jan-Willem, Hoogenboom, Hennie R.

“…Human antibodies selectively targeting angiogenic vessels hold great promise for the immunotherapy of human malignancies and can help to elucidate the…”
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Clonal origin of trisomy for chromosome 7 in the epithelial compartment of colon neoplasia by Herbergs, Jos, Arends, Jan-Willem, Bongers, Ernie M.H. F., Ramaekers, Frans C. S., Hopman, Anton H. N.

“…In this study, we demonstrated the clonal origin of trisomy for chromosome 7 in epithelial cells of colon neoplasia. By using the double‐target fluorescence in…”
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IN SITU HYBRIDIZATION AND FLOW CYTOMETRIC ANALYSIS OF COLORECTAL TUMOURS SUGGESTS TWO ROUTES OF TUMOURIGENESIS CHARACTERIZED BY GAIN OF CHROMOSOME 7 OR LOSS OF CHROMOSOMES 17 AND 18 by HERBERGS, JOS, HOPMAN, ANTON H. N., DE BRUÏNE, ADRIAAN P., RAMAEKERS, FRANS C. S., ARENDS, JAN-WILLEM

“…Chromosomal aberrations in colonic tumourigenesis were investigated by fluorescence in situ hybridization (FISH) with centromere‐specific DNA probes and…”
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