Search Results - "Arends, H."

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    Harnessing Clinical Trial and Real-World Data Towards an Understanding of Sex Effects on Drug Pharmacokinetics, Pharmacodynamics and Efficacy by Oi Yan Chan, Joyce, Moullet, Marie, Williamson, Beth, Arends, Rosalinda H., Pilla Reddy, Venkatesh

    Published in Frontiers in pharmacology (06-06-2022)
    “…Increasing clinical data on sex-related differences in drug efficacy and toxicity has highlighted the importance of understanding the impact of sex on drug…”
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    Journal Article
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    Comparing the applications of machine learning, PBPK, and population pharmacokinetic models in pharmacokinetic drug–drug interaction prediction by Gill, Jaidip, Moullet, Marie, Martinsson, Anton, Miljković, Filip, Williamson, Beth, Arends, Rosalinda H., Pilla Reddy, Venkatesh

    “…The gold‐standard approach for modeling pharmacokinetic mediated drug–drug interactions is the use of physiologically‐based pharmacokinetic modeling and…”
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    Evaluating the performance of machine‐learning regression models for pharmacokinetic drug–drug interactions by Gill, Jaidip, Moullet, Marie, Martinsson, Anton, Miljković, Filip, Williamson, Beth, Arends, Rosalinda H., Pilla Reddy, Venkatesh

    “…Combination therapy or concomitant drug administration can be associated with pharmacokinetic drug–drug interactions, increasing the risk of adverse drug…”
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    Development of and insights from systems pharmacology models of antibody‐drug conjugates by Lam, Inez, Pilla Reddy, Venkatesh, Ball, Kathryn, Arends, Rosalinda H., Mac Gabhann, Feilim

    “…Antibody‐drug conjugates (ADCs) have gained traction in the oncology space in the past few decades, with significant progress being made in recent years…”
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    Dose and Schedule Study of Panitumumab Monotherapy in Patients with Advanced Solid Malignancies by WEINER, Louis M, BELLDEGRUN, Arie S, CRAWFORD, Jeffrey, TOLCHER, Anthony W, LOCKBAUM, Pamela, ARENDS, Rosalin H, NAVALE, Lynn, AMADO, Rafael G, SCHWAB, Gisela, FIGLIN, Robert A

    Published in Clinical cancer research (15-01-2008)
    “…Purpose: This phase 1 study evaluated the safety, pharmacokinetics, and activity of panitumumab, a fully human, IgG2 monoclonal antibody that targets the…”
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    Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil by UMMENHOFER, W. C, ARENDS, R. H, SHEN, D. D, BERNARDS, C. M

    Published in Anesthesiology (Philadelphia) (01-03-2000)
    “…Despite widespread use, little is known about the comparative pharmacokinetics of intrathecally administered opioids. The present study was designed to…”
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    Population Pharmacokinetics of Cotadutide in Subjects with Type 2 Diabetes by Guan, Ye, Ly, Neang, Li, Jing, Arends, Rosalinda H.

    Published in Clinical pharmacokinetics (01-06-2022)
    “…Background and Objectives Cotadutide is a balanced dual glucagon-like peptide-1/glucagon receptor agonist under development for the treatment of nonalcoholic…”
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