Search Results - "Arend, WP"

Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis by Kuhn, Kristine A, Kulik, Liudmila, Tomooka, Beren, Braschler, Kristin J, Arend, William P, Robinson, William H, Holers, V Michael

“…Antibodies against citrullinated proteins are specific and predictive markers for rheumatoid arthritis although the pathologic relevance of these antibodies…”
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The mode of action of cytokine inhibitors by Arend, William P

“…Tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 (IL-1) are important mediators of inflammation and tissue damage in animal models of inflammatory…”
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INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology by Arend, William P, Malyak, Mark, Guthridge, Carla J, Gabay, Cem

“…The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular response. Two…”
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Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein by Gabay, C, Smith, M F, Eidlen, D, Arend, W P

“…Interleukin 1 receptor antagonist (IL-1Ra) levels are elevated in the blood of patients with a variety of infectious, immune, or traumatic conditions. To…”
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Cytokine imbalance in the pathogenesis of rheumatoid arthritis: The role of interleukin-1 receptor antagonist by Arend, William P.

“…Objectives: To summarize the role of cytokine imbalance in the pathogenesis of rheumatoid arthritis. Methods: The literature on cytokines in rheumatoid…”
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Interleukin 1 receptor antagonist : a new member of the interleukin 1 family by AREND, W. P

“…This review has summarized recent information derived from many laboratories on the discovery, characteristics, and properties of a new member of the IL-1…”
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Biological role of interleukin 1 receptor antagonist isoforms by Arend, William P, Guthridge, Carla J

“…The interleukin 1 receptor antagonist (IL1Ra) family of molecules now includes one secreted isoform (sIL1Ra) and three intracellular isoforms (icIL1Ra1, 2, and…”
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Mechanisms of Inhibition of Collagen-Induced Arthritis by Murine IL-18 Binding Protein by Banda, Nirmal K, Vondracek, Andrea, Kraus, Damian, Dinarello, Charles A, Kim, Soo-Hyun, Bendele, Alison, Senaldi, Giorgio, Arend, William P

“…IL-18 is an important cytokine in autoimmune and inflammatory diseases through the induction of IFN-gamma, TNF-alpha, and IL-1. We report herein that…”
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Interleukin-1 receptor antagonist by Arend, W P

“…IL-1ra is the first described naturally occurring receptor antagonist of any cytokine or hormone-like molecule. IL-1ra is a member of the IL-1 family by three…”
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Cytokines in the rheumatic diseases by Arend, William P, Gabay, Cem

“…Extensive data has accumulated over the last 10 to 15 years to implicate various cytokines in pathways of pathophysiology in rheumatic diseases. Abnormalities…”
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Intracellular IL-1 Receptor Antagonist Type 1 Inhibits IL-1-Induced Cytokine Production in Keratinocytes through Binding to the Third Component of the COP9 Signalosome by Banda, Nirmal K, Guthridge, Carla, Sheppard, Devon, Cairns, Kelly S, Muggli, Michele, Bech-Otschir, Dawadschargal, Dubiel, Wolfgang, Arend, William P

“…The IL-1 receptor antagonist (IL-1Ra) exists in four isoforms, three of which lack signal peptides and are primarily intracellular proteins. The biologic roles…”
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Physiology of cytokine pathways in rheumatoid arthritis by Arend, William P.

“…This review has summarized the physiology of some cytokine pathways in RA, emphasizing the redundant and synergistic nature of this network. However, it is…”
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Production of IL‐1 receptor antagonist by hepatocytes is regulated as an acute‐phase protein in vivo by Gabay, Cem, Gigley, Jason, Sipe, Jean, Arend, William P., Fantuzzi, Giamila

“…IL‐1 receptor antagonist (IL‐1Ra) is produced by isolated human hepatocytes with characteristics of an acute‐phase protein. There are multiple IL‐1Ra peptides,…”
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Interleukin-4 (IL-4) and IL-13 Enhance the Effect of IL-1β on Production of IL-1 Receptor Antagonist by Human Primary Hepatocytes and Hepatoma HepG2 Cells: Differential Effect on C-Reactive Protein Production by Gabay, Cem, Porter, Brandon, Guenette, Denis, Billir, Bahri, Arend, William P.

“…Interleukin-1 receptor antagonist (IL-1Ra) is produced by hepatocytes with characteristics of an acute-phase protein. To examine the role of IL-4 and IL-13 in…”
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The American College of Rheumatology 1990 criteria for the classification of Henoch-Schönlein purpura by Mills, J A, Michel, B A, Bloch, D A, Calabrese, L H, Hunder, G G, Arend, W P, Edworthy, S M, Fauci, A S, Leavitt, R Y, Lie, J T

“…Criteria for identifying Henoch-Schönlein Purpura (HSP) and distinguishing HSP from other forms of systemic arteritis were developed by comparing the…”
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Generation and characterization of mice transgenic for human IL-18-binding protein isoform a by Fantuzzi, Giamila, Banda, Nirmal K., Guthridge, Carla, Vondracek, Andrea, Kim, Soo‐Hyun, Siegmund, Britta, Azam, Tania, Sennello, Joseph A., Dinarello, Charles A., Arend, William P.

“…Interleukin (IL)‐18 binding protein (IL‐18BP) is a natural inhibitor of the pleiotropic cytokine IL‐18. To study the role of IL‐18BP in modulating inflammatory…”
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Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist by Eisenberg, Stephen P, Evans, Ron J, Arend, William P, Verderber, Evie, Brewer, Michael T, Hannum, Charles H, Thompson, Robert C

“…Human monocytes induced with adherent IgG secrete an interleukin-1 receptor antagonist which could be important for the in vivo regulation of IL-1 activity. A…”
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Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids by Arend, WP, Malyak, M, Smith, MF, Jr, Whisenand, TD, Slack, JL, Sims, JE, Giri, JG, Dower, SK

“…These studies have examined the binding of the three IL-1 ligands, IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1 ra), to soluble forms of types I…”
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Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist by Arend, W P, Welgus, H G, Thompson, R C, Eisenberg, S P

“…Human monocytes cultured on adherent IgG produce a specific IL-1 inhibitor that functions as a receptor antagonist (IL-1ra). This molecular has been purified,…”
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Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor by Hannum, Charles H, Wilcox, Carol J, Arend, William P, Joslin, Fenneke G, Dripps, David J, Heimdal, Patricia L, Armes, Lyman G, Sommer, Andreas, Eisenberg, Stephen P, Thompson, Robert C

“…Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with…”
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