Search Results - "Arenas, Fabian"

Intracellular Cholesterol Trafficking and Impact in Neurodegeneration by Arenas, Fabian, Garcia-Ruiz, Carmen, Fernandez-Checa, Jose C

“…Cholesterol is a critical component of membrane bilayers where it plays key structural and functional roles by regulating the activity of diverse signaling…”
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Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia by Gimenez, Neus, Tripathi, Rupal, Giró, Ariadna, Rosich, Laia, López-Guerra, Mònica, López-Oreja, Irene, Playa-Albinyana, Heribert, Arenas, Fabian, Mas, José Manuel, Pérez-Galán, Patricia, Delgado, Julio, Campo, Elias, Farrés, Judith, Colomer, Dolors

“…Chronic lymphocytic leukemia (CLL) is a B lymphoid malignancy highly dependent on the microenvironment. Despite new targeted therapies such as ibrutinib and…”
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Factors associated with suffering from dying in patients with cancer: a cross-sectional analytical study among bereaved caregivers by Arango-Gutiérrez, Angélica, Moreno, Socorro, Rondón, Martín, Arroyo, Lucía I, Ardila, Liliana, Leal Arenas, Fabián Alexander, Calvache, José A, de Vries, Esther

“…In Colombia, cancer incidence is increasing, as is the demand for end-of-life care. Understanding how patients who die from cancer experience this phase will…”
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Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy by Silkenstedt, Elisabeth, Arenas, Fabian, Colom-Sanmartí, Berta, Xargay-Torrent, Sílvia, Higashi, Morihiro, Giró, Ariadna, Rodriguez, Vanina, Fuentes, Patricia, Aulitzky, Walter E, van der Kuip, Heiko, Beà, Sílvia, Toribio, Maria L, Campo, Elias, López-Guerra, Mònica, Colomer, Dolors

“…NOTCH1 gene mutations in mantle cell lymphoma (MCL) have been described in about 5-10% of cases and are associated with significantly shorter survival rates…”
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Medical decisions concerning the end of life for cancer patients in three Colombian hospitals – a survey study by de Vries, Esther, Leal Arenas, Fabián Alexander, van der Heide, Agnes, Gempeler Rueda, Fritz E, Murillo, Raul, Morales, Olga, Diaz-Amado, Eduardo, Rodríguez, Nelcy, Gonzalez, Beatriz Juliana, Castilblanco Delgado, Danny Steven, Calvache, Jose A

“…Abstract Background Cancer patients’ end-of-life care may involve complex decision-making processes. Colombia has legislation regarding provision of and access…”
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Bicarbonate Secretion of Mouse Cholangiocytes Involves Na+-HCO3- Cotransport in Addition to Na+-Independent Cl-/HCO3- Exchange by URIARTE, Iker, BANALES, Jesús M, SAEZ, Elena, ARENAS, Fabián, OUDE ELFERINK, Ronald P. J, PRIETO, Jesús, MEDINA, Juan F

“…Bicarbonate secretion from cholangiocytes is required for appropriate adjustment of primary canalicular bile along the biliary tract. In human and rat…”
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Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target by Dobaño-López, Cèlia, Valero, Juan García, Araujo-Ayala, Ferran, Nadeu, Ferran, Gava, Fabien, Faria, Carla, Norlund, Marine, Morin, Renaud, Bernes-Lasserre, Pascale, Arenas, Fabian, Grau, Marta, López, Cristina, López-Oreja, Irene, Serrat, Neus, Martínez-Farran, Ares, Hernández, Lluís, Playa-Albinyana, Heribert, Giménez, Rubén, Beà, Silvia, Campo, Elías, Lagarde, Jean-Michel, López-Guillermo, Armando, Magnano, Laura, Colomer, Dolors, Bezombes, Christine, Pérez-Galán, Patricia

“…Follicular lymphoma (FL), the most common indolent non-Hodgkin lymphoma, constitutes a paradigm of immune tumor microenvironment (TME) contribution to disease…”
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GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver by Goicoechea, Leire, Arenas, Fabian, Castro, Fernanda, Nuñez, Susana, Torres, Sandra, Garcia-Ruiz, Carmen, Fernandez-Checa, José C.

“…Abnormal cholesterol metabolism is linked to many neurodegenerative disorders. Here, we present a protocol for the production of a recombinant protein…”
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The receptor of the colony-stimulating factor-1 (CSF-1R) is a novel prognostic factor and therapeutic target in follicular lymphoma by Valero, Juan Garcia, Matas-Céspedes, Alba, Arenas, Fabián, Rodriguez, Vanina, Carreras, Joaquim, Serrat, Neus, Guerrero-Hernández, Martina, Yahiaoui, Anella, Balagué, Olga, Martin, Silvia, Capdevila, Cristina, Hernández, Lluis, Magnano, Laura, Rivas-Delgado, Alfredo, Tannheimer, Stacey, Cid, Maria C., Campo, Elías, López-Guillermo, Armando, Colomer, Dolors, Pérez-Galán, Patricia

“…Microenvironment contributes to follicular lymphoma (FL) pathogenesis and impacts survival with macrophages playing a controversial role. In the present study,…”
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Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells by Arenas, Fabián, Hervias, Isabel, Uriz, Miriam, Joplin, Ruth, Prieto, Jesús, Medina, Juan F

“…Primary biliary cirrhosis (PBC) is a cholestatic disease associated with autoimmune phenomena and alterations in both biliary bicarbonate excretion and…”
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Challenges with Approved Targeted Therapies against Recurrent Mutations in CLL: A Place for New Actionable Targets by López-Oreja, Irene, Playa-Albinyana, Heribert, Arenas, Fabián, López-Guerra, Mónica, Colomer, Dolors

“…Chronic lymphocytic leukemia (CLL) is characterized by a high degree of genetic variability and interpatient heterogeneity. In the last decade, novel…”
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A collection of three integration-free iPSCs derived from old male and female healthy subjects by Rodríguez-Traver, Eva, Díaz-Guerra, Eva, Rodríguez, César, Arenas, Fabián, Orera, María, Kulisevsky, Jaime, Moratalla, Rosario, Vicario, Carlos

“…Here, we present the characterization of three iPSC lines derived from dermal fibroblasts of old healthy subjects. Fibroblasts were reprogrammed using Sendai…”
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Advantages and disadvantages of mouse models of chronic lymphocytic leukemia in drug discovery by Playa-Albinyana, Heribert, Arenas, Fabian, Colomer, Dolors

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A collection of integration-free iPSCs derived from Parkinson's disease patients carrying mutations in the GBA1 gene by Rodríguez-Traver, Eva, Díaz-Guerra, Eva, Rodríguez, César, Fernández, Pablo, Arenas, Fabián, Araúzo-Bravo, Marcos, Orera, María, Kulisevsky, Jaime, Moratalla, Rosario, Vicario, Carlos

“…Mutations in the GBA1 gene, which encodes the lysosomal enzyme Glucocerebrosidase1 are major risk factors for Parkinson's disease (PD) and dementia with Lewy…”
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Generation of an integration-free iPSC line, ICCSICi005-A, derived from a Parkinson's disease patient carrying the L444P mutation in the GBA1 gene by Rodríguez-Traver, Eva, Rodríguez, César, Díaz-Guerra, Eva, Arenas, Fabián, Araúzo-Bravo, Marcos, Orera, María, Kulisevsky, Jaime, Moratalla, Rosario, Vicario, Carlos

“…The L444P mutation in the GBA1 gene which encodes β-glucocerebrosidase-1, is a major risk factor for developing Parkinson's disease (PD) and dementia with Lewy…”
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Promoter hypermethylation of the AE2/SLC4A2 gene in PBC by Arenas, Fabián, Hervías, Isabel, Sáez, Elena, Melero, Saida, Prieto, Jesús, Parés, Albert, Medina, Juan F

“…Patients with primary biliary cholangitis (PBC) exhibit reduced gene expression in the liver and peripheral blood mononuclear cells (PBMCs). encodes a Cl /HCO…”
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Bicarbonate-rich choleresis induced by secretin in normal rat is taurocholate-dependent and involves AE2 anion exchanger by HANALES, Jesus M, ARENAS, Fabian, RODRIGUEZ-ORTIGOSA, Carlos M, SAEZ, Elena, URIARTE, Iker, DOCTOR, R. Brian, PRIETO, Jesus, MEDINA, Juan F

“…Canalicular bile is modified along bile ducts through reabsorptive and secretory processes regulated by nerves, bile salts, and hormones such as secretin…”
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Generation of Richter Transformation Models throughout Chronic Lymphocytic Leukemia Patient-Derived Xenografts: A Clonal Evolution Model by Playa-Albinyana, Heribert, Arenas, Fabian, Royo, Romina, Giró, Ariadna, López, Irene, Lopez-Guerra, Monica, Beà, Sílvia, Campo, Elías, Nadeu, Ferran, Colomer, Dolors

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Chronic lymphocytic leukemia patient-derived xenografts recapitulate clonal evolution to Richter transformation by Playa-Albinyana, Heribert, Arenas, Fabian, Royo, Romina, Giró, Ariadna, López-Oreja, Irene, Aymerich, Marta, López-Guerra, Mònica, Frigola, Gerard, Beà, Sílvia, Delgado, Julio, Garcia-Roves, Pablo M., Campo, Elías, Nadeu, Ferran, Colomer, Dolors

“…Chronic lymphocytic leukemia (CLL) is a B-cell neoplasm with a heterogeneous clinical behavior. In 5–10% of patients the disease transforms into a diffuse…”
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STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndrome by Arenas, Fabian, Castro, Fernanda, Nuñez, Susana, Gay, Gemma, Garcia-Ruiz, Carmen, Fernandez-Checa, Jose C

“…Alzheimer´s disease (AD) is a progressive neurodegenerative disorder of complex etiology, while Down syndrome (DS) is considered a genetically determined form…”
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