Immunological and physiological effects of chronic exposure of Peromyscus leucopus to Aroclor 1254 at a concentration similar to that found at contaminated sites

Immunological and physiological effects of chronic exposure of Peromyscus leucopus to Aroclor 1254 at a concentration similar to that found at contaminated sites

Polychlorinated biphenyls (PCBs) are environmental contaminants known to cause adverse health effects to biological systems. Limited data are available on their effects on the immune system of wildlife species. Previously, we found that 4 and 6-week-old white-footed mice ( Peromyscus leucopus) born...

Full description

Saved in:
Bibliographic Details
Published in:Toxicology (Amsterdam) Vol. 174; no. 3; pp. 163 - 172
Main Authors: Segre, Mariangela, Arena, Sandra M., Greeley, Elizabeth H., Melancon, Mark J., Graham, Dawn A., French, John B.
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 05-06-2002
Amsterdam Elsevier Science
Subjects:
Animal, plant and microbial ecology
Animals
Applied ecology
Aroclor 1254
Biological and medical sciences
Body Burden
Cell Count
Cell Division - drug effects
Chlorodiphenyl (54% Chlorine) - toxicity
Cytochrome P-450 Enzyme System - metabolism
Diet
Ecotoxicology, biological effects of pollution
Effects of pollution and side effects of pesticides on vertebrates
Enzyme-Linked Immunosorbent Assay
Female
Fundamental and applied biological sciences. Psychology
Immunity - drug effects
Immunity, Cellular - drug effects
Immunotoxicity
Leukocyte Count
Mammalia
Mitogens - toxicity
Organ Size - drug effects
Peromyscus
Peromyscus leucopus
Polychlorinated biphenyls (PCBs)
Pregnancy
Prenatal Exposure Delayed Effects
Aroclor 1254
Polychlorinated biphenyls (PCBs)
Peromyscus leucopus
Immunotoxicity
Immunopathology
Toxicity
Placental transfer
Rodentia
Oral administration
Milk transfer
Wild life
Breast feeding
Polychlorobiphenyl
Postnatal development
Pregnancy
Progeny
Pollutant
Vertebrata
Mammalia
Environment
Immune system
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Polychlorinated biphenyls (PCBs) are environmental contaminants known to cause adverse health effects to biological systems. Limited data are available on their effects on the immune system of wildlife species. Previously, we found that 4 and 6-week-old white-footed mice ( Peromyscus leucopus) born from dams injected with a single dose (300 mg/kg) of Aroclor 1254, had altered immunological, hematological, and biochemical responses. Here, we examined the effect of transplacental, lactational and postnatal exposure to Aroclor 1254, at a concentration similar to that found at contaminated sites, on various physiological parameters of 22-week-old white-footed mice. Liver weight and liver somatic index of PCB treated animals were significantly higher, the combined weights of the adrenal glands were significantly lower and EROD and BROD enzyme activity was significantly higher compared to control values. The number of thymocytes of the treated mice was significantly lower than that of the controls; however, thymocytes of treated mice had a higher proliferative response to the mitogen Con A. These alterations were correlated with the PCBs body burdens. Some toxic effects of chronic exposure to PCBs, at levels comparable to exposure found in contaminated sites in the USA, are still evident in adult P. leucopus.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0300-483X
1879-3185
DOI:10.1016/S0300-483X(02)00039-2