Search Results - "Arellano, Martha L."

Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth by Jin, Lingtao, Li, Dan, Alesi, Gina N., Fan, Jun, Kang, Hee-Bum, Lu, Zhou, Boggon, Titus J., Jin, Peng, Yi, Hong, Wright, Elizabeth R., Duong, Duc, Seyfried, Nicholas T., Egnatchik, Robert, DeBerardinis, Ralph J., Magliocca, Kelly R., He, Chuan, Arellano, Martha L., Khoury, Hanna J., Shin, Dong M., Khuri, Fadlo R., Kang, Sumin

“…How mitochondrial glutaminolysis contributes to redox homeostasis in cancer cells remains unclear. Here we report that the mitochondrial enzyme glutamate…”
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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth by Hitosugi, Taro, Zhou, Lu, Elf, Shannon, Fan, Jun, Kang, Hee-Bum, Seo, Jae Ho, Shan, Changliang, Dai, Qing, Zhang, Liang, Xie, Jianxin, Gu, Ting-Lei, Jin, Peng, Alečković, Masa, LeRoy, Gary, Kang, Yibin, Sudderth, Jessica A., DeBerardinis, Ralph J., Luan, Chi-Hao, Chen, Georgia Z., Muller, Susan, Shin, Dong M., Owonikoko, Taofeek K., Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Ye, Keqiang, Boggon, Titus J., Kang, Sumin, He, Chuan, Chen, Jing

“…It is unclear how cancer cells coordinate glycolysis and biosynthesis to support rapidly growing tumors. We found that the glycolytic enzyme phosphoglycerate…”
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Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth by Shan, Changliang, Elf, Shannon, Ji, Quanjiang, Kang, Hee-Bum, Zhou, Lu, Hitosugi, Taro, Jin, Lingtao, Lin, Ruiting, Zhang, Liang, Seo, Jae Ho, Xie, Jianxin, Tucker, Meghan, Gu, Ting-Lei, Sudderth, Jessica, Jiang, Lei, DeBerardinis, Ralph J., Wu, Shaoxiong, Li, Yuancheng, Mao, Hui, Chen, Peng R., Wang, Dongsheng, Chen, Georgia Zhuo, Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Brat, Daniel J., Ye, Keqiang, Boggon, Titus J., He, Chuan, Kang, Sumin, Fan, Jun, Chen, Jing

“…Although the oxidative pentose phosphate pathway is important for tumor growth, how 6-phosphogluconate dehydrogenase (6PGD) in this pathway is upregulated in…”
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Two-year follow-up of KTE-X19 in patients with relapsed or refractory adult B-cell acute lymphoblastic leukemia in ZUMA-3 and its contextualization with SCHOLAR-3, an external historical control study by Shah, Bijal D, Ghobadi, Armin, Oluwole, Olalekan O, Logan, Aaron C, Boissel, Nicolas, Cassaday, Ryan D, Leguay, Thibaut, Bishop, Michael R, Topp, Max S, Tzachanis, Dimitrios, O'Dwyer, Kristen M, Arellano, Martha L, Lin, Yi, Baer, Maria R, Schiller, Gary J, Park, Jae H, Subklewe, Marion, Abedi, Mehrdad, Minnema, Monique C, Wierda, William G, DeAngelo, Daniel J, Stiff, Patrick, Jeyakumar, Deepa, Dong, Jinghui, Adhikary, Sabina, Zhou, Lang, Schuberth, Petra C, Faghmous, Imi, Masouleh, Behzad Kharabi, Houot, Roch

“…Brexucabtagene autoleucel (KTE-X19) is an autologous anti-CD19 CAR T-cell therapy approved in the USA to treat adult patients with relapsed or refractory…”
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Secondary Adult Acute Myeloid Leukemia: a Review of Our Evolving Understanding of a Complex Disease Process by Zeichner, Simon B., Arellano, Martha L.

“…Opinion Statement Secondary AML (s-AML) encompasses AML evolving from myelodysplasia (AML-MDS) and treatment-related AML (t-AML) after exposure to…”
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Impact of prior therapies and subsequent transplantation on outcomes in adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia treated with brexucabtagene autoleucel in ZUMA-3 by Shah, Bijal D, Cassaday, Ryan D, Park, Jae H, Houot, Roch, Oluwole, Olalekan O, Logan, Aaron C, Boissel, Nicolas, Leguay, Thibaut, Bishop, Michael R, Topp, Max S, Tzachanis, Dimitrios, O'Dwyer, Kristen M, Arellano, Martha L, Lin, Yi, Baer, Maria R, Schiller, Gary J, Subklewe, Marion, Abedi, Mehrdad, Minnema, Monique C, Wierda, William G, DeAngelo, Daniel J, Stiff, Patrick J, Jeyakumar, Deepa, Mao, Daqin, Adhikary, Sabina, Zhou, Lang, Schuberth, Petra C, Damico Khalid, Rita, Ghobadia, Armin

“…Background Brexucabtagene autoleucel (brexu-cel) is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy approved in the USA for adults with…”
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Impact of Venetoclax and Azacitidine in Treatment-Naïve Patients with Acute Myeloid Leukemia and IDH1/2 Mutations by Pollyea, Daniel A, DiNardo, Courtney D, Arellano, Martha L, Pigneux, Arnaud, Fiedler, Walter, Konopleva, Marina, Rizzieri, David A, Smith, B Douglas, Shinagawa, Atsushi, Lemoli, Roberto M, Dail, Monique, Duan, Yinghui, Chyla, Brenda, Potluri, Jalaja, Miller, Catherine L, Kantarjian, Hagop M

“…To evaluate efficacy and safety of venetoclax + azacitidine among treatment-naïve patients with IDH1/2-mutant (mut) acute myeloid leukemia (AML). Data were…”
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KTE-X19 for relapsed or refractory adult B-cell acute lymphoblastic leukaemia: phase 2 results of the single-arm, open-label, multicentre ZUMA-3 study by Shah, Bijal D, Ghobadi, Armin, Oluwole, Olalekan O, Logan, Aaron C, Boissel, Nicolas, Cassaday, Ryan D, Leguay, Thibaut, Bishop, Michael R, Topp, Max S, Tzachanis, Dimitrios, O'Dwyer, Kristen M, Arellano, Martha L, Lin, Yi, Baer, Maria R, Schiller, Gary J, Park, Jae H, Subklewe, Marion, Abedi, Mehrdad, Minnema, Monique C, Wierda, William G, DeAngelo, Daniel J, Stiff, Patrick, Jeyakumar, Deepa, Feng, Chaoling, Dong, Jinghui, Shen, Tong, Milletti, Francesca, Rossi, John M, Vezan, Remus, Masouleh, Behzad Kharabi, Houot, Roch

“…Despite treatment with novel therapies and allogeneic stem-cell transplant (allo-SCT) consolidation, outcomes in adult patients with relapsed or refractory…”
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ERRATUM: Managing acute promyelocytic leukemia in patients belonging to the Jehovah's Witness congregation by Jillella, Anand P, Arellano, Martha L, Heffner, Leonard T, Gaddh, Manila, Langston, Amelia A, Khoury, Hanna J, Mangaonkar, Abhishek, Kota, Vamsi K

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Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia by Roboz, Gail J., DiNardo, Courtney D., Stein, Eytan M., de Botton, Stéphane, Mims, Alice S., Prince, Gabrielle T., Altman, Jessica K., Arellano, Martha L., Donnellan, Will, Erba, Harry P., Mannis, Gabriel N., Pollyea, Daniel A., Stein, Anthony S., Uy, Geoffrey L., Watts, Justin M., Fathi, Amir T., Kantarjian, Hagop M., Tallman, Martin S., Choe, Sung, Dai, David, Fan, Bin, Wang, Hongfang, Zhang, Vickie, Yen, Katharine E., Kapsalis, Stephanie M., Hickman, Denice, Liu, Hua, Agresta, Samuel V., Wu, Bin, Attar, Eyal C., Stone, Richard M.

“…Ivosidenib (AG-120) is an oral, targeted agent that suppresses production of the oncometabolite 2-hydroxyglutarate via inhibition of the mutant isocitrate…”
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Flotetuzumab as salvage immunotherapy for refractory acute myeloid leukemia by Uy, Geoffrey L., Aldoss, Ibrahim, Foster, Matthew C., Sayre, Peter H., Wieduwilt, Matthew J., Advani, Anjali S., Godwin, John E., Arellano, Martha L., Sweet, Kendra L., Emadi, Ashkan, Ravandi, Farhad, Erba, Harry P., Byrne, Michael, Michaelis, Laura, Topp, Max S., Vey, Norbert, Ciceri, Fabio, Carrabba, Matteo Giovanni, Paolini, Stefania, Huls, Gerwin A., Jongen-Lavrencic, Mojca, Wermke, Martin, Chevallier, Patrice, Gyan, Emmanuel, Récher, Christian, Stiff, Patrick J., Pettit, Kristen M., Löwenberg, Bob, Church, Sarah E., Anderson, Erica, Vadakekolathu, Jayakumar, Santaguida, Marianne, Rettig, Michael P., Muth, John, Curtis, Teia, Fehr, Erin, Guo, Kuo, Zhao, Jian, Bakkacha, Ouiam, Jacobs, Kenneth, Tran, Kathy, Kaminker, Patrick, Kostova, Maya, Bonvini, Ezio, Walter, Roland B., Davidson-Moncada, Jan K., Rutella, Sergio, DiPersio, John F.

“…Approximately 50% of acute myeloid leukemia (AML) patients do not respond to induction therapy (primary induction failure [PIF]) or relapse after <6 months…”
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KTE-X19 anti-CD19 CAR T-cell therapy in adult relapsed/refractory acute lymphoblastic leukemia: ZUMA-3 phase 1 results by Shah, Bijal D., Bishop, Michael R., Oluwole, Olalekan O., Logan, Aaron C., Baer, Maria R., Donnellan, William B., O'Dwyer, Kristen M., Holmes, Houston, Arellano, Martha L., Ghobadi, Armin, Pagel, John M., Lin, Yi, Cassaday, Ryan D., Park, Jae H., Abedi, Mehrdad, Castro, Januario E., DeAngelo, Daniel J., Malone, Adriana K., Mawad, Raya, Schiller, Gary J., Rossi, John M., Bot, Adrian, Shen, Tong, Goyal, Lovely, Jain, Rajul K., Vezan, Remus, Wierda, William G.

“…ZUMA-3 is a phase 1/2 study evaluating KTE-X19, an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, in adult relapsed/refractory (R/R)…”
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6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling by Lin, Ruiting, Elf, Shannon, Shan, Changliang, Kang, Hee-Bum, Ji, Quanjiang, Zhou, Lu, Hitosugi, Taro, Zhang, Liang, Zhang, Shuai, Seo, Jae Ho, Xie, Jianxin, Tucker, Meghan, Gu, Ting-Lei, Sudderth, Jessica, Jiang, Lei, Mitsche, Matthew, DeBerardinis, Ralph J., Wu, Shaoxiong, Li, Yuancheng, Mao, Hui, Chen, Peng R., Wang, Dongsheng, Chen, Georgia Zhuo, Hurwitz, Selwyn J., Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Lei, Qunying, Brat, Daniel J., Ye, Keqiang, Boggon, Titus J., He, Chuan, Kang, Sumin, Fan, Jun, Chen, Jing

“…The oxidative pentose phosphate pathway (PPP) contributes to tumour growth, but the precise contribution of 6-phosphogluconate dehydrogenase (6PGD), the third…”
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Managing acute promyelocytic leukemia in patients belonging to the Jehovah's Witness congregation by Jillella, Anand P, Arellano, Martha L, Heffner, Leonard T, Gaddh, Manila, Langston, Amelia A, Khoury, Hanna J, Mangoankar, Abhishek, Kota, Vamsi K

“…Acute promyelocytic leukemia (APL) is a hyper-acute leukemia and presents with cytopenias and disseminated intravascular coagulation. Jehovah’s Witnesses with…”
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Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth by Fan, Jun, Lin, Ruiting, Xia, Siyuan, Chen, Dong, Elf, Shannon E., Liu, Shuangping, Pan, Yaozhu, Xu, Haidong, Qian, Zhiyu, Wang, Mei, Shan, Changliang, Zhou, Lu, Lei, Qun-Ying, Li, Yuancheng, Mao, Hui, Lee, Benjamin H., Sudderth, Jessica, DeBerardinis, Ralph J., Zhang, Guojing, Owonikoko, Taofeek, Gaddh, Manila, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Kang, Sumin, Doetsch, Paul W., Lonial, Sagar, Boggon, Titus J., Curran, Walter J., Chen, Jing

“…Mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) regulates pyruvate dehydrogenase complex (PDC) by acetylating pyruvate dehydrogenase (PDH) and PDH…”
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A Phase II, Multicenter, Open-Label Study of Obatoclax Mesylate in Patients With Previously Untreated Myelodysplastic Syndromes With Anemia or Thrombocytopenia by Arellano, Martha L, Borthakur, Gautam, Berger, Mark, Luer, Jill, Raza, Azra

“…Micro-Abstract Curative therapies are lacking for older patients with myelodysplastic syndrome (MDS). In this small phase II study, the B-cell lymphoma 2…”
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Entospletinib with decitabine in acute myeloid leukemia with mutant TP53 or complex karyotype: A phase 2 substudy of the Beat AML Master Trial by Duong, Vu H., Ruppert, Amy S., Mims, Alice S., Borate, Uma, Stein, Eytan M., Baer, Maria R., Stock, Wendy, Kovacsovics, Tibor, Blum, William, Arellano, Martha L., Schiller, Gary J., Olin, Rebecca L., Foran, James M., Litzow, Mark R., Lin, Tara L., Patel, Prapti A., Foster, Matthew C., Redner, Robert L., Al‐Mansour, Zeina, Cogle, Christopher R., Swords, Ronan T., Collins, Robert H., Vergilio, Jo‐Anne, Heerema, Nyla A., Rosenberg, Leonard, Yocum, Ashley O., Marcus, Sonja, Chen, Timothy, Druggan, Franchesca, Stefanos, Mona, Gana, Theophilus J., Shoben, Abigail B., Druker, Brian J., Burd, Amy, Byrd, John C., Levine, Ross L., Boyiadzis, Michael M.

“…Background Patients with acute myeloid leukemia (AML) who have tumor protein p53 (TP53) mutations or a complex karyotype have a poor prognosis, and…”
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Results of a randomized phase 3 study of oral sapacitabine in elderly patients with newly diagnosed acute myeloid leukemia (SEAMLESS) by Kantarjian, Hagop M., Begna, Kebede H., Altman, Jessica K., Goldberg, Stuart L., Sekeres, Mikkael A., Strickland, Stephen A., Arellano, Martha L., Claxton, David F., Baer, Maria R., Gautier, Marc, Berman, Ellin, Seiter, Karen, Solomon, Scott R., Schiller, Gary J., Luger, Selina M., Butrym, Aleksandra, Gaidano, Gianluca, Thomas, Xavier G., Montesinos, Pau, Rizzieri, David A., Quick, Donald P., Venugopal, Parameswaran, Gaur, Rakesh, Maness, Lori J., Kadia, Tapan M., Ravandi, Farhad, Buyse, Marc E., Chiao, Judy H.

“…Background Acute myeloid leukemia (AML) is fatal in elderly patients who are unfit for standard induction chemotherapy. The objective of this study was to…”
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Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation by Hitosugi, Taro, Zhou, Lu, Fan, Jun, Elf, Shannon, Zhang, Liang, Xie, Jianxin, Wang, Yi, Gu, Ting-Lei, Alečković, Masa, LeRoy, Gary, Kang, Yibin, Kang, Hee-Bum, Seo, Jae-Ho, Shan, Changliang, Jin, Peng, Gong, Weimin, Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Chen, Georgia Z., Shin, Dong M., Khuri, Fadlo R., Boggon, Titus J., Kang, Sumin, He, Chuan, Chen, Jing

“…How oncogenic signalling coordinates glycolysis and anabolic biosynthesis in cancer cells remains unclear. We recently reported that the glycolytic enzyme…”
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Does Post-Transplant Maintenance Therapy With Tyrosine Kinase Inhibitors Improve Outcomes of Patients With High-Risk Philadelphia Chromosome-Positive Leukemia? by DeFilipp, Zachariah, Langston, Amelia A, Chen, Zhengjia, Zhang, Chao, Arellano, Martha L, El Rassi, Fuad, Flowers, Christopher R, Kota, Vamsi K, Al-Kadhimi, Zaid, Veldman, Rachel, Jillella, Anand P, Lonial, Sagar, Waller, Edmund K, Khoury, Hanna J

“…Micro-Abstract Relapse is the major cause of allogeneic hematopoietic stem cell transplantation failure in high-risk Philadelphia chromosome-positive (Ph+ )…”
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