Search Results - "Arefanian, Hossein"

Functional Foods and Lifestyle Approaches for Diabetes Prevention and Management by Alkhatib, Ahmad, Tsang, Catherine, Tiss, Ali, Bahorun, Theeshan, Arefanian, Hossein, Barake, Roula, Khadir, Abdelkrim, Tuomilehto, Jaakko

“…Functional foods contain biologically active ingredients associated with physiological health benefits for preventing and managing chronic diseases, such as…”
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ROS/TNF-α Crosstalk Triggers the Expression of IL-8 and MCP-1 in Human Monocytic THP-1 Cells via the NF-κB and ERK1/2 Mediated Signaling by Akhter, Nadeem, Wilson, Ajit, Thomas, Reeby, Al-Rashed, Fatema, Kochumon, Shihab, Al-Roub, Areej, Arefanian, Hossein, Al-Madhoun, Ashraf, Al-Mulla, Fahd, Ahmad, Rasheed, Sindhu, Sardar

“…IL-8/MCP-1 act as neutrophil/monocyte chemoattractants, respectively. Oxidative stress emerges as a key player in the pathophysiology of obesity. However, it…”
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Endoplasmic Reticulum Stress Promotes the Expression of TNF-α in THP-1 Cells by Mechanisms Involving ROS/CHOP/HIF-1α and MAPK/NF-κB Pathways by Akhter, Nadeem, Wilson, Ajit, Arefanian, Hossein, Thomas, Reeby, Kochumon, Shihab, Al-Rashed, Fatema, Abu-Farha, Mohamed, Al-Madhoun, Ashraf, Al-Mulla, Fahd, Ahmad, Rasheed, Sindhu, Sardar

“…Obesity and metabolic syndrome involve chronic low-grade inflammation called metabolic inflammation as well as metabolic derangements from increased endotoxin…”
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Verapamil chronicles: advances from cardiovascular to pancreatic β-cell protection by Arefanian, Hossein, Koti, Lubaina, Sindhu, Sardar, Ahmad, Rasheed, Al Madhoun, Ashraf, Al-Mulla, Fahd

“…Verapamil is a well-known drug used for treating angina and hypertension. Emerging data from current clinical trials suggest that this calcium channel blocker…”
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Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells by Marafie, Sulaiman K, Al-Shawaf, Eman M, Abubaker, Jehad, Arefanian, Hossein

“…Free fatty acid receptor 1 (FFAR1) is G-protein coupled receptor predominantly expressed in pancreatic β-cells that is activated by a variety of free fatty…”
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Prognostic Genetic Markers for Thrombosis in COVID-19 Patients: A Focused Analysis on D-Dimer, Homocysteine and Thromboembolism by Abu-Farha, Mohamed, Al-Sabah, Salman, Hammad, Maha M, Hebbar, Prashantha, Channanath, Arshad Mohamed, John, Sumi Elsa, Taher, Ibrahim, Almaeen, Abdulrahman, Ghazy, Amany, Mohammad, Anwar, Abubaker, Jehad, Arefanian, Hossein, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…COVID-19 is caused by Severe Acute Respiratory Syndrome Coronavirus-2, which has infected over thirty eight million individuals worldwide. Emerging evidence…”
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Comparative efficacy, toxicity, and insulin-suppressive effects of simvastatin and pravastatin in fatty acid-challenged mouse insulinoma MIN6 β-cell model by Arefanian, Hossein, Sindhu, Sardar, Al-Rashed, Fatema, Alzaid, Fawaz, Al Madhoun, Ashraf, Qaddoumi, Mohammed, Bahman, Fatemah, Williams, Michayla R., Albeloushi, Shaima, Almansour, Nourah, Ahmad, Rasheed, Al-Mulla, Fahd

“…Introduction Familial hypercholesterolemia, the highly prevalent form of dyslipidemia, is a well-known risk factor for premature heart disease and stroke…”
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Targeting SARS-CoV-2 Macrodomain-1 to Restore the Innate Immune Response Using In Silico Screening of Medicinal Compounds and Free Energy Calculation Approaches by Mohammad, Anwar, Alshawaf, Eman, Arefanian, Hossein, Marafie, Sulaiman K, Khan, Abbas, Wei, Dong-Qing, Al-Mulla, Fahd, Abubaker, Jehad

“…Among the different drug targets of SARS-CoV-2, a multi-domain protein known as NSP3 is a critical element of the translational and replication machinery. The…”
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TNF-α Drives the CCL4 Expression in Human Monocytic Cells: Involvement of the SAPK/JNK and NF-κB Signaling Pathways by Ahmad, Rasheed, Kochumon, Shihab, Chandy, Betty, Shenouda, Steve, Koshy, Merin, Hasan, Amal, Arefanian, Hossein, Al-Mulla, Fahd, Sindhu, Sardar

“…Increased circulatory levels of both TNF-α and CCL4/MIP-1β are found in metabolic diseases. However, it is unclear whether TNF-α which is a signature…”
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IL-1β-Induced CXCL10 Expression in THP-1 Monocytic Cells Involves the JNK/c-Jun and NF-κB-Mediated Signaling by Kochumon, Shihab, Al-Sayyar, Amnah, Jacob, Texy, Arefanian, Hossein, Bahman, Fatemah, Almansour, Nourah, Alzaid, Fawaz, Al-Mulla, Fahd, Sindhu, Sardar, Ahmad, Rasheed

“…CXCL10 (IP-10) plays a key role in leukocyte homing to the inflamed tissues and its increased levels are associated with the pathophysiology of various…”
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Differential effects of fish-oil and cocoa-butter based high-fat/high-sucrose diets on endocrine pancreas morphology and function in mice by Albeloushi, Shaima, Hasan, Amal, Arefanian, Hossein, Sindhu, Sardar, Al-Rashed, Fatema, Kochumon, Shihab, Abukhalaf, Nermeen, Jacob, Texy, Shenouda, Steve, Al Madhoun, Ashraf, Al-Mulla, Fahd, Ahmad, Rasheed

“…A high-fat/high-sucrose diet leads to adverse metabolic changes that affect insulin sensitivity, function, and secretion. The source of fat in the diet might…”
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Soybean oil-based HFD induces gut dysbiosis that leads to steatosis, hepatic inflammation and insulin resistance in mice by Jacob, Texy, Sindhu, Sardar, Hasan, Amal, Malik, Md Zubbair, Arefanian, Hossein, Al-Rashed, Fatema, Nizam, Rasheeba, Kochumon, Shihab, Thomas, Reeby, Bahman, Fatemah, Shenouda, Steve, Wilson, Ajit, Akther, Nadeem, Al-Roub, Areej, Abukhalaf, Nermeen, Albeloushi, Shaima, Abu-Farha, Mohamed, Al Madhoun, Ashraf, Alzaid, Fawaz, Thanaraj, Thangavel Alphonse, Koistinen, Heikki A, Tuomilehto, Jaakko, Al-Mulla, Fahd, Ahmad, Rasheed

“…High-fat diets (HFDs) shape the gut microbiome and promote obesity, inflammation, and liver steatosis. Fish and soybean are part of a healthy diet; however,…”
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Gut Dysbiosis Shaped by Cocoa Butter-Based Sucrose-Free HFD Leads to Steatohepatitis, and Insulin Resistance in Mice by Kochumon, Shihab, Malik, Md Zubbair, Sindhu, Sardar, Arefanian, Hossein, Jacob, Texy, Bahman, Fatemah, Nizam, Rasheeba, Hasan, Amal, Thomas, Reeby, Al-Rashed, Fatema, Shenouda, Steve, Wilson, Ajit, Albeloushi, Shaima, Almansour, Nourah, Alhamar, Ghadeer, Al Madhoun, Ashraf, Alzaid, Fawaz, Thanaraj, Thangavel Alphonse, Koistinen, Heikki A, Tuomilehto, Jaakko, Al-Mulla, Fahd, Ahmad, Rasheed

“…High-fat diets cause gut dysbiosis and promote triglyceride accumulation, obesity, gut permeability changes, inflammation, and insulin resistance. Both cocoa…”
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Oxidative Stress Induces Expression of the Toll-Like Receptors (TLRs) 2 and 4 in the Human Peripheral Blood Mononuclear Cells: Implications for Metabolic Inflammation by Akhter, Nadeem, Madhoun, Ashraf, Arefanian, Hossein, Wilson, Ajit, Kochumon, Shihab, Thomas, Reeby, Shenouda, Steve, Al-Mulla, Fahd, Ahmad, Rasheed, Sindhu, Sardar

“…Innate immune toll-like receptors (TLRs) are emerging as nutrient sensors. Oxidative stress in the adipose tissue in obesity acts as a critical early trigger…”
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MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress by Sindhu, Sardar, Akhter, Nadeem, Wilson, Ajit, Thomas, Reeby, Arefanian, Hossein, Al Madhoun, Ashraf, Al-Mulla, Fahd, Ahmad, Rasheed

“…Metabolic inflammation is associated with increased expression of saturated free fatty acids, proinflammatory cytokines, chemokines, and adipose oxidative…”
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Repetitive Intermittent Hyperglycemia Drives the M1 Polarization and Inflammatory Responses in THP-1 Macrophages Through the Mechanism Involving the TLR4-IRF5 Pathway by Al-Rashed, Fatema, Sindhu, Sardar, Arefanian, Hossein, Al Madhoun, Ashraf, Kochumon, Shihab, Thomas, Reeby, Al-Kandari, Sarah, Alghaith, Abdulwahab, Jacob, Texy, Al-Mulla, Fahd, Ahmad, Rasheed

“…Repetitive intermittent hyperglycemia (RIH) is an independent risk factor for complications associated with type-2 diabetes (T2D). Glucose fluctuations…”
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Increased expression level of ANGPTL8 in white adipose tissue under acute and chronic cold treatment by Arefanian, Hossein, Al-Khairi, Irina, Khalaf, Nermeen Abu, Cherian, Preethi, Kavalakatt, Sina, Madhu, Dhanya, Mathur, Aditi, Qaddoumi, Mohamed G, Al-Mulla, Fahd, Abubaker, Jehad, Abu-Farha, Mohamed

“…Angiopoietin-like proteins (ANGPTL), primarily 3, 4, and 8, play a major role in maintaining energy homeostasis by regulating triglyceride metabolism. This…”
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Adipose Tissue Steroid Receptor RNA Activator 1 (SRA1) Expression Is Associated with Obesity, Insulin Resistance, and Inflammation by Kochumon, Shihab, Arefanian, Hossein, Sindhu, Sardar, Shenouda, Steve, Thomas, Reeby, Al-Mulla, Fahd, Tuomilehto, Jaakko, Ahmad, Rasheed

“…Steroid receptor RNA activator 1 ( ) is involved in pathophysiological responses of adipose tissue (AT) in obesity. In vitro and animal studies have elucidated…”
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Yield, cell composition, and function of islets isolated from different ages of neonatal pigs by Arefanian, Hossein, Ramji, Qahir, Gupta, Nancy, Spigelman, Aliya F, Grynoch, Donald, MacDonald, Patrick E, Mueller, Thomas F, Gazda, Lawrence S, Rajotte, Ray V, Rayat, Gina R

“…The yield, cell composition, and function of islets isolated from various ages of neonatal pigs were characterized using and experimental models. Islets from…”
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Increased Adipose Tissue Expression of IL-23 Associates with Inflammatory Markers in People with High LDL Cholesterol by Kochumon, Shihab, Hasan, Amal, Al-Rashed, Fatema, Sindhu, Sardar, Thomas, Reeby, Jacob, Texy, Al-Sayyar, Amnah, Arefanian, Hossein, Al Madhoun, Ashraf, Al-Ozairi, Ebaa, Alzaid, Fawaz, Koistinen, Heikki A, Al-Mulla, Fahd, Tuomilehto, Jaakko, Ahmad, Rasheed

“…Chronic low-grade inflammation induced by obesity is a central risk factor for the development of metabolic syndrome. High low-density lipoprotein cholesterol…”
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