Cascade polycyclizations in natural product synthesis

Cascade (domino) reactions have an unparalleled ability to generate molecular complexity from relatively simple starting materials; these transformations are particularly appealing when multiple rings are forged during this process. In this tutorial review, we cover recent highlights in cascade poly...

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Bibliographic Details
Published in:	Chemical Society reviews Vol. 45; no. 6; p. 1557
Main Authors:	Ardkhean, R, Caputo, D F J, Morrow, S M, Shi, H, Xiong, Y, Anderson, E A
Format:	Journal Article
Language:	English
Published:	England 21-03-2016
Subjects:	Biological Products - chemical synthesis Catalysis Cyclization
Online Access:	Get more information
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Summary:	Cascade (domino) reactions have an unparalleled ability to generate molecular complexity from relatively simple starting materials; these transformations are particularly appealing when multiple rings are forged during this process. In this tutorial review, we cover recent highlights in cascade polycyclizations as applied to natural product synthesis, including pericyclic, heteroatom-mediated, cationic, metal-catalyzed, organocatalytic, and radical sequences.
ISSN:	1460-4744
DOI:	10.1039/c5cs00105f