Search Results - "Ardi, Veronica C."

Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis by Ardi, Veronica C, Kupriyanova, Tatyana A, Deryugina, Elena I, Quigley, James P

“…Several lines of evidence have implicated matrix metalloproteinase 9 (MMP-9) as a protease inducing an angiogenic switch critical for tumor progression. Among…”
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Tumor-Recruited Neutrophils and Neutrophil TIMP-Free MMP-9 Regulate Coordinately the Levels of Tumor Angiogenesis and Efficiency of Malignant Cell Intravasation by Bekes, Erin M, Schweighofer, Bernhard, Kupriyanova, Tatyana A, Zajac, Ewa, Ardi, Veronica C, Quigley, James P, Deryugina, Elena I

“…Tumor-associated neutrophils contribute to neovascularization by supplying matrix metalloproteinase-9 (MMP-9), a protease that has been genetically and…”
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Twist1 Induces CCL2 and Recruits Macrophages to Promote Angiogenesis by LOW-MARCHELLI, Janine M, ARDI, Veronica C, VIZCARRA, Edward A, ROOIJEN, Nico Van, QUIGLEY, James P, JING YANG

“…The transcription factor Twist1 induces epithelial-mesenchymal transition and extracellular matrix degradation to promote tumor metastasis. Although Twist1…”
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Neutrophil MMP-9 Proenzyme, Unencumbered by TIMP-1, Undergoes Efficient Activation in Vivo and Catalytically Induces Angiogenesis via a Basic Fibroblast Growth Factor (FGF-2)/FGFR-2 Pathway by Ardi, Veronica C., Van den Steen, Philippe E., Opdenakker, Ghislain, Schweighofer, Bernhard, Deryugina, Elena I., Quigley, James P.

“…The structural and catalytic requirements for neutrophil MMP-9 proenzyme (proMMP-9) to induce angiogenesis were investigated using a quantitative angiogenesis…”
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Mechanistic Studies of Sansalvamide A-Amide: An Allosteric Modulator of Hsp90 by Vasko, Robert C, Rodriguez, Rodrigo A, Cunningham, Christian N, Ardi, Veronica C, Agard, David A, McAlpine, Shelli R

“…Herein, we show that sansalvamide A-amide (San A-amide), a structurally unique molecule, influences a subset of cancer-related pathways involving heat shock…”
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Functional Role of Cell Surface CUB Domain-Containing Protein 1 in Tumor Cell Dissemination by Deryugina, Elena I, Conn, Erin M, Wortmann, Andreas, Partridge, Juneth J, Kupriyanova, Tatyana A, Ardi, Veronica C, Hooper, John D, Quigley, James P

“…The function of CUB domain-containing protein 1 (CDCP1), a recently described transmembrane protein expressed on the surface of hematopoietic stem cells and…”
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Functional Analysis of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases Differentially Expressed by Variants of Human HT-1080 Fibrosarcoma Exhibiting High and Low Levels of Intravasation and Metastasis by Partridge, Juneth J., Madsen, Mark A., Ardi, Veronica C., Papagiannakopoulos, Thales, Kupriyanova, Tatyana A., Quigley, James P., Deryugina, Elena I.

“…The role of tumor-derived matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMPs) in cancer cell dissemination was analyzed by…”
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Macrocycles That Inhibit the Binding between Heat Shock Protein 90 and TPR-Containing Proteins by Ardi, Veronica C, Alexander, Leslie D, Johnson, Victoria A, McAlpine, Shelli R

“…Heat shock protein 90 (Hsp90) accounts for 1–2% of the total proteins in normal cells and functions as a molecular chaperone that folds, assembles, and…”
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Synthesis and evaluation of biotinylated sansalvamide A analogs and their modulation of Hsp90 by Kunicki, Joseph B., Petersen, Mark N., Alexander, Leslie D., Ardi, Veronica C., McConnell, Jeanette R., McAlpine, Shelli R.

“…Described are the syntheses of three sansalvamide A derivatives that contain biotinylated tags at individual positions around the macrocycle. The tagged…”
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A comprehensive study of Sansalvamide A derivatives: The structure–activity relationships of 78 derivatives in two pancreatic cancer cell lines by Pan, Po-Shen, Vasko, Robert C., Lapera, Stephanie A., Johnson, Victoria A., Sellers, Robert P., Lin, Chun-Chieh, Pan, Chung-Mao, Davis, Melinda R., Ardi, Veronica C., McAlpine, Shelli R.

“…We report an extensive structure–activity relationship (SAR) of 78 compounds active against two pancreatic cancer cell lines. Our comprehensive evaluation of…”
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Evaluation of metastatic and angiogenic potentials of human colon carcinoma cells in chick embryo model systems by Cecilia Subauste, M, Kupriyanova, Tatyana A, Conn, Erin M, Ardi, Veronica C, Quigley, James P, Deryugina, Elena I

“…Increased metastatic and angiogenic potentials of aggressive human colon carcinoma cells were verified in independent chick embryo models by comparing in vivo…”
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Student Learning in an Accelerated Introductory Biology Course Is Significantly Enhanced by a Flipped-Learning Environment by Barral, Ana Maria, Ardi-Pastores, Veronica C, Simmons, Rachel E

“…A flipped-classroom environment generally strives to create more in-class time for activities that enhance student learning, while shifting some content…”
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Evaluation of Di-Sansalvamide A Derivatives: Synthesis, Structure−Activity Relationship, and Mechanism of Action by Alexander, Leslie D, Sellers, Robert P, Davis, Melinda R, Ardi, Veronica C, Johnson, Victoria A, Vasko, Robert C, McAlpine, Shelli R

“…Described is the SAR of 18 di-sansalvamide A derivatives and the mechanism of action of the most potent compound. We show that this scaffold is a promising…”
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Neutrophil Elastase Facilitates Cancer Cell Motility via Induction of Akt Signaling Pathway by Ardi, Veronica C., Deryugina, Elena I., Quigley, James P.

“…Abstract only Cancer cells create a microenvironment favoring growth of the primary tumor and cancer dissemination. We and others have demonstrated that immune…”
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Active learning in a flipped classroom: implementation and assessment by Barral, Ana Maria, Ardi, Veronica C

“…Abstract only The inverted (“flipped”) classroom approach uses class time to discuss difficult topics, clarify misconceptions, and have students apply the…”
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A comprehensive study of Sansalvamide A derivatives: the structure-activity relationships of 78 derivatives in 2 pancreatic cancer cell lines by Pan, Po-Shen, Vasko, Robert C., Lapera, Stephanie A., Johnson, Victoria A., Sellers, Robert P., Lin, Chun-Chieh, Pan, Chung-Mao, Davis, Melinda R., Ardi, Veronica C., McAlpine, Shelli R.

“…We report an extensive structure-activity relationship (SAR) of seventy-eight compounds active against two pancreatic cancer cell lines. Our comprehensive…”
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Cytosine arabinoside (ara-C) resistance confers cross-resistance or collateral sensitivity to other classes of anti-leukemic drugs by Martin-Aragon, S, Mukherjee, S K, Taylor, B J, Ivy, S P, Fu, C H, Ardi, V C, Avramis, V I

“…The major limitation of treatment with antimetabolite drugs is that they produce resistant clones both in vitro and in patients who either do not respond to…”
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Reversal of cytosine arabinoside (ara-C) resistance by the synergistic combination of 6-thioguanine plus ara-C plus PEG-asparaginase (TGAP) in human leukemia lines lacking or expressing p53 protein by FU, Cecilia H, MARTIN-ARAGON, Sagrario, WEINBERG, Kenneth I, ARDI, Veronica C, DANENBERG, Peter V, AVRAMIS, Vassilios I

“…Sequence-specific combinations of purine analogs, such as fludarabine or 6-mercaptopurine (6-MP), administered prior to cytosine arabinoside (ara-C) have been…”
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