Search Results - "Arden, Susan D."

The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy by Tumbarello, David A, Manna, Paul T, Allen, Mark, Bycroft, Mark, Arden, Susan D, Kendrick-Jones, John, Buss, Folma

“…Autophagy plays a key role during Salmonella infection, by eliminating these pathogens following escape into the cytosol. In this process, selective autophagy…”
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Motor domain phosphorylation increases nucleotide exchange and turns MYO6 into a faster and stronger motor by de Jonge, Janeska J., Graw, Andreas, Kargas, Vasileios, Batters, Christopher, Montanarella, Antonino F., O’Loughlin, Tom, Johnson, Chloe, Arden, Susan D., Warren, Alan J., Geeves, Michael A., Kendrick-Jones, John, Zaccai, Nathan R., Kröss, Markus, Veigel, Claudia, Buss, Folma

“…Myosin motors perform many fundamental functions in eukaryotic cells by providing force generation, transport or tethering capacity. Motor activity control…”
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Loss of cargo binding in the human myosin VI deafness mutant (R1166X) leads to increased actin filament binding by Arden, Susan D, Tumbarello, David A, Butt, Tariq, Kendrick-Jones, John, Buss, Folma

“…Mutations in myosin VI have been associated with autosomal-recessive (DFNB37) and autosomal-dominant (DFNA22) deafness in humans. Here, we characterise an…”
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Myosin VI targeting to clathrin-coated structures and dimerization is mediated by binding to Disabled-2 and PtdIns(4,5)P2 by Spudich, Giulietta, Chibalina, Margarita V, Au, Josephine Sui-Yan, Arden, Susan D, Buss, Folma, Kendrick-Jones, John

“…Vesicle transport is essential for the movement of proteins, lipids and other molecules between membrane compartments within the cell. The role of the class VI…”
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Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis by Sahlender, Daniela A, Roberts, Rhys C, Arden, Susan D, Spudich, Giulietta, Taylor, Marcus J, Luzio, J. Paul, Kendrick-Jones, John, Buss, Folma

“…Myosin VI plays a role in the maintenance of Golgi morphology and in exocytosis. In a yeast 2-hybrid screen we identified optineurin as a binding partner for…”
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Correction: The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy by Tumbarello, David A, Manna, Paul T, Allen, Mark, Bycroft, Mark, Arden, Susan D, Kendrick-Jones, John, Buss, Folma

“…[This corrects the article DOI: 10.1371/journal.ppat.1005174.]…”
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Myosin VI is required for targeted membrane transport during cytokinesis by Arden, Susan D, Puri, Claudia, Au, Josephine Sui-Yan, Kendrick-Jones, John, Buss, Folma

“…Myosin VI plays important roles in endocytic and exocytic membrane-trafficking pathways in cells. Because recent work has highlighted the importance of…”
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The MYO6 interactome: selective motor‐cargo complexes for diverse cellular processes by de Jonge, Janeska J., Batters, Christopher, O'Loughlin, Thomas, Arden, Susan D., Buss, Folma

“…Myosins of class VI (MYO6) are unique actin‐based motor proteins that move cargo towards the minus ends of actin filaments. As the sole myosin with this…”
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Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome by Tumbarello, David A., Waxse, Bennett J., Arden, Susan D., Bright, Nicholas A., Kendrick-Jones, John, Buss, Folma

“…Autophagy targets pathogens, damaged organelles and protein aggregates for lysosomal degradation. These ubiquitylated cargoes are recognized by specific…”
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Myosin VI targeting to clathrin-coated structures and dimerization is mediated by binding to Disabled-2 and PtdIns(4,5)P 2 by Spudich, Giulietta, Au, Josephine Sui-Yan, Buss, Folma, Arden, Susan D, Kendrick-Jones, John, Chibalina, Margarita V

“…Vesicle transport is essential for the movement of proteins, lipids and other molecules between membrane compartments within the cell. The role of the class VI…”
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MYO6 is targeted by Salmonella virulence effectors to trigger PI3-kinase signaling and pathogen invasion into host cells by Brooks, Andrew B. E., Humphreys, Daniel, Singh, Vikash, Davidson, Anthony C., Arden, Susan D., Buss, Folma, Koronakis, Vassilis

“…To establish infections, Salmonella injects virulence effectors that hijack the host actin cytoskeleton and phosphoinositide signaling to drive pathogen…”
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T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion by Morriswood, Brooke, Ryzhakov, Grigory, Puri, Claudia, Arden, Susan D, Roberts, Rhys, Dendrou, Calliope, Kendrick-Jones, John, Buss, Folma

“…Myosin VI has been implicated in many cellular processes including endocytosis, secretion, membrane ruffling and cell motility. We carried out a yeast…”
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Dynamic Exchange of Myosin VI on Endocytic Structures by Bond, Lisa M., Arden, Susan D., Kendrick-Jones, John, Buss, Folma, Sellers, James R.

“…The actin-based molecular motor myosin VI functions in the endocytic uptake pathway, both during the early stages of clathrin-mediated uptake and in later…”
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Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis by Buss, Folma, Arden, Susan D., Lindsay, Margaret, Luzio, J. Paul, Kendrick-Jones, John

“…Myosin VI is involved in membrane traffic and dynamics and is the only myosin known to move towards the minus end of actin filaments. Splice variants of myosin…”
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Myosin VI Binds to and Localises with Dab2, Potentially Linking Receptor‐Mediated Endocytosis and the Actin Cytoskeleton by Morris, Shelli M., Arden, Susan D., Roberts, Rhys C., Kendrick‐Jones, John, Cooper, Jonathan A., Luzio, J. Paul, Buss, Folma

“…Myosin VI, an actin‐based motor protein, and Disabled 2 (Dab2), a molecule involved in endocytosis and cell signalling, have been found to bind together using…”
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Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein by Arden, S D, Zahn, T, Steegers, S, Webb, S, Bergman, B, O'Brien, R M, Hutton, J C

“…Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. S D Arden , T Zahn , S Steegers , S Webb , B Bergman…”
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Rab8-optineurin-myosin VI: analysis of interactions and functions in the secretory pathway by Chibalina, Margarita V, Roberts, Rhys C, Arden, Susan D, Kendrick-Jones, John, Buss, Folma

“…The small GTPase Rab8 has been shown to regulate polarized membrane trafficking pathways from the TGN to the cell surface. Optineurin is an effector protein of…”
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The MYO 6 interactome: selective motor‐cargo complexes for diverse cellular processes by de Jonge, Janeska J., Batters, Christopher, O'Loughlin, Thomas, Arden, Susan D., Buss, Folma

“…Myosins of class VI ( MYO 6) are unique actin‐based motor proteins that move cargo towards the minus ends of actin filaments. As the sole myosin with this…”
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T-cell reactivity to β-cell membrane antigens associated with β-cell destruction in IDDM by ROEP, B. O, KALLAN, A. A, DUINKERKEN, G, ARDEN, S. D, HUTTON, J. C, BRUINING, G. J, DE VRIES, R. R. P

“…Insulin-dependent diabetes mellitus (IDDM) results from a T-cell-mediated destruction of the insulin-producing beta-cells. In this study, we designed a…”
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T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins by Roep, Bart O, Arden, Susan D, de vries, René R. P, Hutton, John C

“…T LYMPHOCYTES reactive to pancreatic beta-cells are thought to have a central role in the autoimmune process leading to type 1 (insulin-dependent) diabetes,…”
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