Search Results - "Arden, James R"
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Tissue Manganese Concentrations in Young Male Rhesus Monkeys following Subchronic Manganese Sulfate Inhalation
Published in Toxicological sciences (01-07-2006)“…High-dose human exposure to manganese results in manganese accumulation in the basal ganglia and dopaminergic neuropathology. Occupational manganese…”
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Maternal–fetal Distribution of Manganese in the Rat Following Inhalation Exposure to Manganese Sulfate
Published in Neurotoxicology (Park Forest South) (01-08-2005)“…Studies examining the pharmacokinetics of manganese during pregnancy have largely focused on the oral route of exposure and have shown that the amount of…”
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3
Olfactory Neuron Loss in Adult Male CD Rats Following Subchronic Inhalation Exposure to Hydrogen Sulfide
Published in Toxicologic pathology (01-03-2000)“…Dysosmia and anosmia are reported to occur following human exposure to hydrogen sulfide (H2S) gas. The clinical association between H2S exposure and olfactory…”
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Toxicity and occupational exposure assessment for hydroprocessed esters and fatty acids (HEFA) alternative jet fuels
Published in Journal of Toxicology and Environmental Health, Part A (03-03-2020)“…The U.S. Air Force (USAF) has pursued development of alternative fuels to augment or replace petroleum-based jet fuels. Hydroprocessed esters and fatty acids…”
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Acute and two-week inhalation toxicity studies in rats for Polyalphaolefin (PAO) fluid
Published in Journal of Toxicology and Environmental Health, Part A (02-01-2021)“…Formal occupational exposure limits (OELs) for polyalphaolefin (PAO) fluids have not been proposed. Specific PAO fluids are utilized as aircraft hydraulics or…”
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Acute toxicity when concentration varies with time: A case study with carbon monoxide inhalation by rats
Published in Regulatory toxicology and pharmacology (01-10-2016)“…Exposure to time-varying concentrations of toxic compounds is the norm in both occupational settings and daily human life, but little has been done to…”
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Neurotoxicological Effects Associated with Short-Term Exposure of Sprague–Dawley Rats to Hydrogen Sulfide
Published in Neurotoxicology (Park Forest South) (01-06-2001)“…Although hydrogen sulfide (H 2S) is a known neurotoxic hazard, only a limited number of experimental animal studies have examined its neurochemical or…”
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Cytochrome oxidase inhibition induced by acute hydrogen sulfide inhalation: Correlation with tissue sulfide concentrations in the rat brain, liver, lung, and nasal epithelium
Published in Toxicological sciences (2002)“…Hydrogen sulfide (H2S) is an important brain, lung, and nose toxicant. Inhibition of cytochrome oxidase is the primary biochemical effect associated with…”
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Olfactory Mucosal Necrosis in Male CD Rats Following Acute Inhalation Exposure to Hydrogen Sulfide: Reversibility and the Possible Role of Regional Metabolism
Published in Toxicologic pathology (01-03-2002)“…Hydrogen sulfide (H 2S) is a potent inhibitor of cytochrome oxidase (CO) and is associated with dysosmia and anosmia in humans and nasal lesions in exposed…”
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Evaluation of submarine atmospheres: effects of carbon monoxide, carbon dioxide and oxygen on general toxicology, neurobehavioral performance, reproduction and development in rats. I. Subacute exposures
Published in Inhalation toxicology (01-02-2015)“…Abstract The inhalation toxicity of submarine contaminants is of concern to ensure the health of men and women aboard submarines during operational…”
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Developmental toxicity evaluation of inhaled tertiary amyl methyl ether in mice and rats
Published in Journal of applied toxicology (01-11-2003)“…This evaluation was part of a much more comprehensive testing program to characterize the mammalian toxicity potential of the gasoline oxygenator additive…”
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Evaluation of submarine atmospheres: effects of carbon monoxide, carbon dioxide and oxygen on general toxicology, neurobehavioral performance, reproduction and development in rats. II. Ninety-day study
Published in Inhalation toxicology (01-02-2015)“…Abstract Carbon monoxide (CO), carbon dioxide (CO2) and low-level oxygen (O2) (hypoxia) are submarine atmosphere components of highest concern because of a…”
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Cognitive decline in older subjects
Published in Anesthesiology (Philadelphia) (01-05-2010)Get full text
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Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats
Published in Toxicology and applied pharmacology (01-06-2004)“…In this study, we examined whether gender or age influences the pharmacokinetics of manganese sulfate (MnSO 4) or manganese phosphate (as the mineral form…”
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Reciprocal translocations in somatic and germ cells of mice chronically exposed by inhalation to ethylene oxide: implications for risk assessment
Published in Mutagenesis (01-01-2010)“…Groups of male B6C3F1 mice were exposed by inhalation to 0, 25, 50, 100 or 200 p.p.m. ethylene oxide (EO) for up to 48 weeks (6 hours/day, 5 days/week)…”
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Tissue Manganese Concentrations in Lactating Rats and Their Offspring Following Combined in Utero and Lactation Exposure to Inhaled Manganese Sulfate
Published in Toxicological sciences (01-03-2005)“…There is little information regarding the tissue distribution of manganese in neonates following inhalation. This study determined tissue manganese…”
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Development and use of a single-animal whole-body system for inhalation exposure
Published in Lab animal (2008)“…Inhalation exposure studies, in which test subjects are fully or partially immersed in an atmosphere containing a compound of interest, are usually carried out…”
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The Effect of Ethylene Exposure on Ethylene Oxide in Blood and on Hepatic Cytochrome P450 in Fischer Rats
Published in Toxicological sciences (01-09-2004)“…Ethylene (74-85-1) is an important petrochemical and is produced endogenously. It is metabolized to ethylene oxide (EO) by cytochrome P450. We studied the…”
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Respiration in Sprague-Dawley Rats During Pregnancy
Published in Inhalation toxicology (01-04-2006)“…Minute ventilation and tidal volume increase in humans during pregnancy. Little data exists, however, on the respiration in pregnant rats, despite their…”
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DEVELOPMENT OF AN INHALATION SYSTEM FOR THE SIMULTANEOUS EXPOSURE OF RAT DAMS AND PUPS DURING DEVELOPMENTAL NEUROTOXICITY STUDIES
Published in Inhalation toxicology (1998)“…Due to mass flux constraints, the exposure of pups along with dams to particles cannot be easily done in traditional whole-body inhalation systems. Typical…”
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