Search Results - "Ardan, T."

In vitro and in vivo evaluation of genetically corrected RPE cells for autologous cell therapy of hereditary retinal dystrophies by Rodriguez‐Jimenez, F. J., Brymova, A., Mueller, B., Stieger, K., Jendelova, P., Ardan, T., Studenovská, H., Lytvynchuk, L., Straňák, Z., Ellederová, Z., Juhás, J., Motlík, J., Petrovski, G., Erceg, Lukovic D.

“…Purpose: The generation of genetically corrected RPE cells from patient‐derived human induced pluripotent stem cells (hiPSCs) may provide a source for…”
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Upregulated expression of proteolytic enzymes in the cultured retinal pigment epithelial cells of minipig transgenic for the human mutated huntingtin by Ardan, T., Kocurova, G., Hrnciarova, E., Motlik, J.

“…Purpose Huntington′s disease (HD) belongs to the hereditary neurodegenerative disorder that is caused by an expansion of a polyglutamine (polyQ) domain in the…”
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Nanofibrous carrier for transplantation of retinal pigment epithelial cells by Ardan, T., Popelka, Š., Straňák, Z., Kozak, I., Lytvynchuk, L., Rais, D., Dušková, M., Motlík, J.

“…Summary The most common retinal degenerative diseases such as age‐related macular degeneration (AMD) and retinitis pigmentosa belong to serious eye diseases…”
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Decreased expression of antioxidant enzymes in the conjunctival epithelium of dry eye (Sjögren's syndrome) and its possible contribution to the development of ocular surface oxidative injuries by Cejková, J, Ardan, T, Simonová, Z, Cejka, C, Malec, J, Dotrelová, D, Brunová, B

“…Previous studies have described elevated lipid peroxidase, myeloperoxidase and xanthine oxidoreductase/xanthine oxidase levels on the ocular surface of…”
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UV Rays, the prooxidant/antioxidant imbalance in the cornea and oxidative eye damage by Cejková, J, Stípek, S, Crkovská, J, Ardan, T, Pláteník, J, Cejka, C, Midelfart, A

“…In this minireview, the factors involved in the development of corneal injury due to an increased amount of UVB rays are summarized. Experimental studies have…”
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Nitric oxide synthase induction and cytotoxic nitrogen-related oxidant formation in conjunctival epithelium of dry eye (Sjögren‘s syndrome) by Čejková, J., Ardan, T., Šimonová, Z., Čejka, Č., Malec, J., Jirsová, K., Filipec, M., Dotřelová, D., Brůnová, B.

“…Until now, the expression and possible role of nitric oxide and nitrogen related oxidants in the human dry eye have not been investigated. Therefore, we…”
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Irradiation of the rabbit cornea with UVB rays stimulates the expression of nitric oxide synthases-generated nitric oxide and the formation of cytotoxic nitrogen-related oxidants by Cejková, J, Ardan, T, Cejka, C, Kovaceva, J, Zídek, Z

“…Until now, the role of nitric oxide (NO) in cornea irradiated with UVB rays remains unknown. Therefore, we investigated nitric oxide synthase isomers (NOS),…”
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Changes of superoxide dismutase, catalase and glutathione peroxidase in the corneal epithelium after UVB rays. Histochemical and biochemical study by Cejková, J, Stípek, S, Crkovská, J, Ardan, T

“…In this study, the effects of UVA and UVB rays on antioxidant enzymes (superoxide dismutase, glutathione peroxidase, catalase) were examined in the corneal…”
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Ocular surface injuries in autoimmune dry eye. The severity of microscopical disturbances goes parallel with the severity of symptoms of dryness by Cejková, J, Ardan, T, Cejka, C, Malec, J, Jirsová, K, Filipec, M, Ruzicková, E, Dotrelová, D, Brunová, B

“…Autoimmune dry eye (Sjögren's syndrome, SS) is a chronic systemic disease characterized by salivary and lacrimal gland inflammation and tissue damage leading…”
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The role of conjunctival epithelial cell xanthine oxidoreductase/xanthine oxidase in oxidative reactions on the ocular surface of dry eye patients with Sjögren's syndrome by Cejková, J, Ardan, T, Jirsová, K, Jechová, G, Malec, J, Simonová, Z, Cejka, C, Filipec, M, Dotrelová, D, Brunová, B

“…Previous papers examined lipid peroxidase levels and myeloperoxidase activity as products of oxidative and inflammatory reactions in the tear fluid of patients…”
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Changes of corneal optical properties after UVB irradiation investigated spectrophotometrically by Cejka, C, Pláteník, J, Sirc, J, Ardan, T, Michálek, J, Brůnová, B, Čejková, J

“…Ozone depletion leads to an increase in UV rays of solar radiation reaching the surface of the Earth which is harmful to biological systems. Of the eye, the…”
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Reactive oxygen species (ROS)-generating oxidases in the normal rabbit cornea and their involvement in the corneal damage evoked by UVB rays by Cejková, J, Stípek, S, Crkovská, J, Ardan, T, Midelfart, A

“…The corneas of albino rabbits were irradiated (5 min exposure once a day) with UVB rays (312 nm) for 4 days (shorter procedure) or 8 days (longer procedure)…”
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Differences in activities of antioxidant superoxide dismutase, glutathione peroxidase and prooxidant xanthine oxidoreductase/xanthine oxidase in the normal corneal epithelium of various mammals by Kovaceva, J, Pláteník, J, Vejrazka, M, Stípek, S, Ardan, T, Cejka, C, Midelfart, A, Cejková, J

“…Under normal conditions, antioxidants at the corneal surface are balanced with the production of reactive oxygen species without any toxic effects. Danger from…”
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Expression of stromelysins 2 and 3 in rabbit corneal epithelium upon UV radiation by ARDAN, T

“…Purpose Stromelysins belong to the group of matrix metalloproteinases (MMPs). These enzymes degrade many extracellular matrix proteins in the basement…”
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Xanthine oxidoreductase and xanthine oxidase in human cornea by Cejková, J, Ardan, T, Filipec, M, Midelfart, A

“…Xanthine oxidoreductase (xanthine dehydrogenase + xanthine oxidase) is a complex enzyme that catalyzes the oxidation of hypoxanthine to xanthine, subsequently…”
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Changes in expression of matrix metalloproteinases 12 and 19 in corneal epithelial cells after UV irradiation by ARDAN, T, CEJKOVA, J

“…Purpose Matrix metalloproteinases (MMPs) are zinc‐binding endopeptidases that degrade various components of extracellular matrix. MMP‐12 participates in…”
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C15 Screening Of Huntington's Disease Markers In The Brain Of Transgenic Minipigs For The Human Mutated Huntingtin (f2 Generation, Age 24 Months) by Vochozkova, P., Ardan, T., Juhas, S., Vochyanova, K., Motlik, J.

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C15Screening Of Huntington's Disease Markers In The Brain Of Transgenic Minipigs For The Human Mutated Huntingtin (f2 Generation, Age 24 Months) by Vochozkova, P, Ardan, T, Juhas, S, Vochyanova, K, Motlik, J

“…BackgroundThe discovery of the huntingtin gene enabled the creation of transgenic HD models including the transgenic minipigs (TgHD) used in this study. The…”
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Expression of tissue inhibitors of matrix metalloproteinases 1 and 2 in corneal epithelium after UV irradiation by ARDAN, T, CEJKOVA, J

“…Purpose Tissue inhibitors of metalloproteinases (TIMPs) are capable of inhibiting the activities of all known matrix metalloproteinases (MMPs) and therefore…”
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Expression of Huntingtons disease markers in the cornea of minipig transgenic for the human mutated huntingtin by ARDAN, T, JUHAS, S, MOTLIK, J

“…Purpose Huntingtons disease (HD) is a neurodegenerative disorder that is caused by an expansion of a polyglutamine (polyQ) domain in the protein of huntingtin…”
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