Search Results - "Archives of drug information"

Drugs Used in the Treatment of Rheumatoid Arthritis: Relationship between Current Use and Cardiovascular Risk Factors by Rho, Young Hee, Oeser, Annette, Chung, Cecilia P., Milne, Ginger L., Stein, C. Michael

“…ABSTRACT Objectives.  Drugs used for the treatment of rheumatoid arthritis (RA) have the potential to affect cardiovascular risk factors. There is concern that…”
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Probiotic Pre‐treatment Reduces Gliclazide Permeation (ex vivo) in Healthy Rats but Increases It in Diabetic Rats to the Level Seen in Untreated Healthy Rats by Al‐Salami, Hani, Butt, Grant, Tucker, Ian, Skrbic, Ranko, Golocorbin‐Kon, Svetlana, Mikov, Momir

“…ABSTRACT Aim.  To investigate the influence of probiotic pre‐treatment on the permeation of the antidiabetic drug gliclazide in healthy and diabetic rats…”
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Is Ciprofloxacin a Substrate of P‐glycoprotein? by Park, Miki Susanto, Okochi, Hideaki, Benet, Leslie Z.

“…ABSTRACT Introduction.  Studies using MDCKII and LLC‐PK1 cells transfected with MDR1 cDNA indicate that ciprofloxacin is not a substrate of P‐glycoprotein…”
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Hydrocortisone Diffusion Through Synthetic Membrane, Mouse Skin, and Epiderm™ Cultured Skin by Christensen, John Mark, Chuong, Monica Chang, Le, Hang, Pham, Loan, Bendas, Ehab

“…ABSTRACT Objectives.  The penetration of hydrocortisone (HC) from six topical over‐the‐counter products along with one prescription cream through cultured…”
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Unexpected Hepatotoxicity of Rifampin and Saquinavir/Ritonavir in Healthy Male Volunteers by Schmitt, Christophe, Riek, Myriam, Winters, Katie, Schutz, Malte, Grange, Susan

“…ABSTRACT Objectives.  Rifampin is a potent inducer of the cytochrome P450 3A4 isoenzyme (CYP3A4) that metabolizes most protease inhibitor (PI) antiretrovirals…”
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Phase I Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD4877 in Japanese Patients with Solid Tumors by Esaki, Taito, Seto, Takashi, Ariyama, Hiroshi, Arita, Shuji, Fujimoto, Chinatsu, Tsukasa, Koichiro, Kometani, Takuro, Nosaki, Kaname, Hirai, Fumihiko, Yagawa, Katsuro

“…ABSTRACT Introduction.  AZD4877 is a potent Eg5 inhibitor that has been shown to have an acceptable tolerability profile in a Phase I study of Western patients…”
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Epoetin Theta in Anaemic Cancer Patients Receiving Platinum‐Based Chemotherapy: A Randomised Controlled Trial by Tjulandin, Sergei A., Bias, Peter, Elsässer, Reiner, Gertz, Beate, Kohler, Erich, Buchner, Anton

“…ABSTRACT Introduction.  Recombinant human erythropoietin (r‐HuEPO) is used to treat symptomatic anaemia due to chemotherapy. A new r‐HuEPO, Epoetin theta…”
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Epoetin Theta with a New Dosing Schedule in Anaemic Cancer Patients Receiving Nonplatinum‐Based Chemotherapy: A Randomised Controlled Trial by Tjulandin, Sergei A., Bias, Peter, Elsässer, Reiner, Gertz, Beate, Kohler, Erich, Buchner, Anton

“…ABSTRACT Introduction.  Recombinant human erythropoietin (r‐HuEPO) is used to treat symptomatic anaemia due to chemotherapy. A new r‐HuEPO, Epoetin theta…”
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Ascorbic Acid Potentiation of Arsenic Trioxide Anticancer Activity Against Acute Promyelocytic Leukemia by Yedjou, Clement, Thuisseu, Laurette, Tchounwou, Christine, Gomes, Maria, Howard, Carolyn, Tchounwou, Paul

“…ABSTRACT Introduction.  Acute promyelocytic leukemia (APL) is a malignant disorder of the white blood cells. Arsenic trioxide (As2O3) has been used as a…”
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Assessing the Impact of Efalizumab on Nail, Scalp and Palmoplantar Psoriasis and on Quality of Life: Results from a Multicentre, Open‐label, Phase IIIb/IV Trial by Katsambas, Andreas, Peris, Ketty, Vena, Gino, Freidmann, Peter, Wozel, Gottfried, Daudén, Esteban, Licu, Daiana, Placchi, Mauro, De La Brassinne, Michel

“…ABSTRACT This post‐approval, open‐label trial (n = 1266) assessed the efficacy of efalizumab, administered in accordance with the European label at that time,…”
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The Dose Proportionality of Telcagepant after Administration of Single Oral and Intravenous Doses in Healthy Adult Subjects by Han, Tae H., Blanchard, Rebecca L., Palcza, John, Martucci, Ashley, Miller‐Stein, Cynthia M., Gutierrez, Maria, Panebianco, Deborah, Rippley, Ronda K., Lines, Christopher, Murphy, M. Gail

“…ABSTRACT Introduction.  Telcagepant (MK‐0974) is a novel, orally active and selective CGRP receptor antagonist being investigated for acute treatment of…”
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Bioequivalence of the 4‐mg Oral Granules and Chewable Tablet Formulations of Montelukast by Knorr, Barbara, Hartford, Alan, Li, Xiujiang (Susie), Yang, Amy Yifan, Noonan, Gertrude, Migoya, Elizabeth

“…ABSTRACT Purpose.  The primary objective of the studies was to demonstrate bioequivalence between the oral granules formulation and chewable tablet of…”
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Effect of 4‐Aminopyridine on Action Potential Parameters in Isolated Dog Purkinje Fibers by Thomas, George, Klatt, Brian, Blight, Andrew

“…ABSTRACT Introduction.  4‐Aminopyridine (fampridine), a potassium channel blocker, has demonstrated efficacy in improving lower extremity strength and walking…”
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Effects of 4‐Aminopyridine on Cloned hERG Channels Expressed in Mammalian Cells by Renganathan, Muthukrishnan, Sidach, Serguei, Blight, Andrew R.

“…ABSTRACT Introduction.  Non‐clinical evaluation of a medication's potential to induce cardiac toxicity is recommended by regulatory agencies. 4‐Aminopyridine…”
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Efficacy and Safety of Efalizumab in Patients with Moderate‐to‐Severe Plaque Psoriasis Resistant to Previous Anti‐Psoriatic Treatment: Results of a Multicentre, Open‐label, Phase IIIb/IV Trial by Lotti, Torello, Chimenti, Sergio, Katsambas, Andreas, Ortonne, Jean‐Paul, Dubertret, Louis, Licu, Daiana, Simon, Jan

“…ABSTRACT Objectives.  To evaluate the efficacy and safety of efalizumab in continuous or interrupted therapy of adults with moderate‐to‐severe plaque psoriasis…”
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Epoetin Theta with a New Dosing Schedule in Anaemic Cancer Patients Receiving Nonplatinum-Based Chemotherapy: A Randomised Controlled Trial: Epoetin Theta and Nonplatinum Chemotherapy by Tjulandin, Sergei A., Bias, Peter, Elsässer, Reiner, Gertz, Beate, Kohler, Erich, Buchner, Anton

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Control of Moderate‐to‐Severe Plaque Psoriasis with Efalizumab: 24‐Week, Open‐Label, Phase IIIb/IV Latin American Study Results by Stengel, Fernando M., Petri, Valeria, Campbell, Gladys A.M., Dorantes, Gladys Leon, López, Magdalina, Galimberti, Ricardo L., Valdez, Raúl P., De Arruda, Lucia F., Guerra, Mario Amaya, Chouela, Edgardo N., Licu, Daiana

“…ABSTRACT Introduction.  Psoriasis is a debilitating, chronic inflammatory systemic disease affecting around 2% of the South American population. Biological…”
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Phase I Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD4877 in Japanese Patients with Solid Tumors: Phase I Study of AZD4877 in Solid Tumors by Esaki, Taito, Seto, Takashi, Ariyama, Hiroshi, Arita, Shuji, Fujimoto, Chinatsu, Tsukasa, Koichiro, Kometani, Takuro, Nosaki, Kaname, Hirai, Fumihiko, Yagawa, Katsuro

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Efalizumab in the Treatment of Scalp, Palmoplantar and Nail Psoriasis: Results of a 24‐Week Latin American Study by Takahashi, María Denise, Chouela, Edgardo Néstor, Dorantes, Gladys Leon, Roselino, Ana Maria, Santamaria, Jesùs, Allevato, Miguel Angel, Cestari, Tania, De Aillaud, Maria Eugenia Manzanera, Stengel, Fernando Miguel, Licu, Daiana

“…ABSTRACT Introduction.  Plaque‐type psoriasis affecting the nails, scalp, hands or feet can often be difficult to treat; for example, topical treatments and…”
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A Phase 3, Randomized, Placebo‐controlled Trial of Filgrastim in Patients with Haematological Malignancies Undergoing Matched‐related Allogeneic Bone Marrow Transplantation by Ernst, Peter, Bacigalupo, Andrea, Ringdén, Olle, Ruutu, Tapani, Kolb, Hans J., Lawrinson, Susan, Skacel, Tomas

“…ABSTRACT Introduction.  Recombinant granulocyte colony‐stimulating factor (G‐CSF) may aid engraftment post high‐dose chemo‐/radiotherapy in patients with…”
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