Search Results - "Archives of biochemistry and biophysics"

Osteoblast and osteocyte: Games without frontiers by Capulli, Mattia, Paone, Riccardo, Rucci, Nadia

“…•Osteoblastogenesis and the classical functions of the osteoblast.•Osteocytogenesis and the classical functions of the osteocyte.•New osteoblast functions:…”
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Cyanidin-3-O-glucoside restores insulin signaling and reduces inflammation in hypertrophic adipocytes by Molonia, Maria Sofia, Occhiuto, Cristina, Muscarà, Claudia, Speciale, Antonio, Bashllari, Romina, Villarroya, Francesc, Saija, Antonella, Cimino, Francesco, Cristani, Mariateresa

“…Obesity is a metabolic disorder characterized by excess adipose tissue, macrophages infiltration, and inflammation which in turn lead to insulin-resistance…”
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Osteocytes promote osteoclastogenesis via autophagy-mediated RANKL secretion under mechanical compressive force by Li, Wenlei, Zhao, Jing, Sun, Wen, Wang, Hua, Pan, Yongchu, Wang, Lin, Zhang, Wei-Bing

“…Osteocytes sense extracellular mechanical stimuli and transduce them into biochemical signals to regulate bone remodeling. The function is also evidenced in…”
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Hemistepsin A protects human keratinocytes against hydrogen peroxide-induced oxidative stress through activation of the Nrf2/HO-1 signaling pathway by Park, Cheol, Lee, Hyesook, Noh, Jeong Sook, Jin, Cheng-Yun, Kim, Gi-Young, Hyun, Jin Won, Leem, Sun-Hee, Choi, Yung Hyun

“…Hemistepsin A, a sesquiterpene lactone compound isolated from Hemistepta lyrata, has been identified a variety of pharmacological actions including…”
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Heme uptake and utilization by hypervirulent Acinetobacter baumannii LAC-4 is dependent on a canonical heme oxygenase (abHemO) by Giardina, Bennett J., Shahzad, Saba, Huang, Weiliang, Wilks, Angela

“…Acinetobacter baumannii is an opportunistic pathogen that causes serious infections in critically ill and immune compromised patients. The ability to acquire…”
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Curcumin ameliorates focal segmental glomerulosclerosis by inhibiting apoptosis and oxidative stress in podocytes by Zhang, Hui, Dong, Qing-Qing, Shu, Hua-Pan, Tu, Yu-Chi, Liao, Qian-Qian, Yao, Li-Jun

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Naringin prevents bone loss in a rat model of type 1 Diabetes mellitus by Rivoira, M., Rodríguez, V., Picotto, G., Battaglino, R., Tolosa de Talamoni, N.

“…The aim of this work was to know whether naringin (NA) could prevent the bone complications in a model of streptozotocin (STZ) induced diabetes. Rats were…”
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Trimebutine suppresses Toll-like receptor 2/4/7/8/9 signaling pathways in macrophages by Ogawa, Natsumi, Nakajima, Shingo, Tamada, Kenya, Yokoue, Natsuki, Tachibana, Haruki, Okazawa, Miwa, Oyama, Takahiro, Abe, Hideaki, Yamazaki, Hiroaki, Yoshimori, Atsushi, Sato, Akira, Kamiya, Takanori, Yokomizo, Takehiko, Uchiumi, Fumiaki, Abe, Takehiko, Tanuma, Sei-ichi

“…Because of the critical roles of Toll-like receptors (TLRs) and receptor for advanced glycation end-products (RAGE) in the pathophysiology of various acute and…”
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I86A/C295A mutant secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus has broadened substrate specificity for aryl ketones by Nealon, Christopher M., Welsh, Travis P., Kim, Chang Sup, Phillips, Robert S.

“…Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase (SADH) reduces aliphatic ketones according to Prelog's Rule, with binding pockets for small and…”
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TRIB3 downregulation enhances doxorubicin-induced cytotoxicity in gastric cancer cells by Wu, I.-Jung, Lin, Rong-Jaan, Wang, Hsin-Chiao, Yuan, Tein-Ming, Chuang, Show-Mei

“…TRIB3, which is a pseudokinase known to regulate multiple pro-survival pathways, appears to be a potential therapeutic target for the treatment of human…”
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Coenzyme Q10 redox balance and a free radical scavenger drug by Yamamoto, Yorihiro

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Cinnamon improves insulin sensitivity and alters the body composition in an animal model of the metabolic syndrome by Couturier, K., Batandier, C., Awada, M., Hininger-Favier, I., Canini, F., Anderson, R.A., Leverve, X., Roussel, A.M.

“…Polyphenols from cinnamon (CN) have been described recently as insulin sensitizers and antioxidants but their effects on the glucose/insulin system in vivo…”
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Acetylome study in mouse adipocytes identifies targets of SIRT1 deacetylation in chromatin organization and RNA processing by Kim, Sun-Yee, Sim, Choon Kiat, Tang, Hui, Han, Weiping, Zhang, Kangling, Xu, Feng

“…SIRT1 is a key protein deacetylase that regulates cellular metabolism through lysine deacetylation on both histones and non-histone proteins. Lysine…”
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EGCG disaggregates amyloid-like fibrils formed by Plasmodium falciparum merozoite surface protein 2 by Chandrashekaran, Indu R., Adda, Christopher G., MacRaild, Christopher A., Anders, Robin F., Norton, Raymond S.

“…► Merozoite surface protein 2 (MSP2), a malaria surface antigen, forms amyloid-like fibrils in solution. ► EGCG disaggregates pre-formed MSP2 fibrils into…”
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Kinesins and protein kinases: Key players in the regulation of microtubule dynamics and organization by Daire, Vanessa, Poüs, Christian

“…► Role of kinesins in microtubule disassembly and mitotic spindle organization and dynamics; modulation by protein kinases. ► Control of microtubule assembly…”
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A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo by Henry, E.C., Bemis, J.C., Henry, O., Kende, A.S., Gasiewicz, T.A.

“…The aryl hydrocarbon receptor (AhR) is best known as a mediator of toxicity of a diverse family of xenobiotic chemicals such as dioxins and PCBs. However, many…”
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Recent progress in molecular genetic studies on the carotenoid transport system using cocoon-color mutants of the silkworm by Tsuchida, Kozo, Sakudoh, Takashi

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The flavonoid fisetin promotes nerve cell survival from trophic factor withdrawal by enhancement of proteasome activity by Maher, Pamela

“…To explore the possibility that specific flavonoids can substitute for neurotrophic factors, we examined the ability of the flavonol fisetin and several…”
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Leukotriene B4: Metabolism and Signal Transduction by Yokomizo, Takehiko, Izumi, Takashi, Shimizu, Takao

“…Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Enzymes…”
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Involvement of actin cytoskeleton in macrophage apoptosis induced by cationic liposomes by Takano, Katsuki, Sato, Kaori, Negishi, Yoichi, Aramaki, Yukihiko

“…► Actin cytoskeleton is implicated in macrophage apoptosis induced by cationic liposomes. ► Actin cytoskeleton is considered to be linked to PKCδ activation…”
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