Search Results - "Archiv der Pharmazie (Weinheim)"

Discovery of sulfadrug–pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors by Gümüş, Mehmet, Babacan, Şemsi N., Demir, Yeliz, Sert, Yusuf, Koca, İrfan, Gülçin, İlhami

“…Human carbonic anhydrase (hCA) isoenzymes are zinc ion‐containing, widespread metalloenzymes and they classically play a role in pH homeostasis maintenance. CA…”
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1,2,3‐Triazole hybrids as anticancer agents: A review by Alam, Mohammad Mahboob

“…Despite the advancements in the development of anticancer agents, more effective and safer anticancer drugs still need to be developed as the current agents…”
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1,2,3‐Triazole hybrids with anti‐HIV‐1 activity by Feng, Lian‐Shun, Zheng, Man‐Jie, Zhao, Feng, Liu, Duan

“…The human immunodeficiency virus type 1 (HIV‐1) is the major etiological agent responsible for the acquired immunodeficiency syndrome (AIDS), which is a…”
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Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR‐2 inhibitors by El‐Helby, Abdel‐Ghany A., Sakr, Helmy, Eissa, Ibrahim H., Abulkhair, Hamada, Al‐Karmalawy, Ahmed A., El‐Adl, Khaled

“…Novel series of benzoxazoles 4a‐f‐16 were designed, synthesized, and evaluated for anticancer activity against HepG2, HCT‐116, and MCF‐7 cells. HCT‐116 was the…”
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Emerging therapeutic potentials of dual‐acting MAO and AChE inhibitors in Alzheimer's and Parkinson's diseases by Mathew, Bijo, Parambi, Della G. T., Mathew, Githa E., Uddin, Md. Sahab, Inasu, Sini T., Kim, Hoon, Marathakam, Akash, Unnikrishnan, Mazhuvancherry Kesavan, Carradori, Simone

“…No drug has been approved to prevent neuronal cell loss in patients suffering from Parkinson's disease (PD) or Alzheimer's disease (AD); despite increased…”
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Coumarin derivatives with anticancer activities: An update by Song, Xu‐Feng, Fan, Jing, Liu, Lan, Liu, Xiao‐Feng, Gao, Feng

“…Cancer can invade or spread to almost all parts of the body. The increasing morbidity and high mortality of cancer create a great demand for the development of…”
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Coumarin‐containing hybrids and their antibacterial activities by Feng, Dongxu, Zhang, Aihua, Yang, Yuan, Yang, Peng

“…Infections caused by Gram‐positive and ‐negative bacteria are one of the foremost causes of morbidity and mortality globally. Antibiotics are the mainstay of…”
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Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors by Kalaycı, Muharrem, Türkeş, Cüneyt, Arslan, Mustafa, Demir, Yeliz, Beydemir, Şükrü

“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia, memory impairment, cognitive dysfunction, and speech impairment. The…”
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Recent advances in isatin hybrids as potential anticancer agents by Ding, Zhen, Zhou, Minfeng, Zeng, Cheng

“…The isatin framework is a useful template for the development of novel anticancer agents. This is exemplified by the fact that several isatin‐based anticancer…”
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Discovery of novel pyrazole and pyrazolo[1,5‐a]pyrimidine derivatives as cyclooxygenase inhibitors (COX‐1 and COX‐2) using molecular modeling simulation by Ayman, Radwa, Radwan, A. M., Elmetwally, Amira M., Ammar, Yousry A., Ragab, Ahmed

“…Searching for effective and selective anti‐inflammatory agents, our study involved designing and synthesizing new pyrazole and pyrazolo[1,5‐a]pyrimidine…”
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Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds by Sever, Belgin, Türkeş, Cüneyt, Altıntop, Mehlika D., Demir, Yeliz, Akalın Çiftçi, Gülşen, Beydemir, Şükrü

“…New hybrid thiazolyl–pyrazoline derivatives (4a–k) were obtained through a facile and versatile synthetic procedure, and their inhibitory effects on the human…”
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1,3,5‐Triazine: A versatile pharmacophore with diverse biological activities by Singh, Saumya, Mandal, Milan K., Masih, Anup, Saha, Ashmita, Ghosh, Surajit K., Bhat, Hans R., Singh, Udaya P.

“…1,3,5‐Triazine and its derivatives have been the epicenter of chemotherapeutic molecules due to their effective biological activities, such as antibacterial,…”
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Design and discovery of new 1,2,4‐triazolo[4,3‐c]quinazolines as potential DNA intercalators and topoisomerase II inhibitors by Alesawy, Mohamed S., Al‐Karmalawy, Ahmed A., Elkaeed, Eslam B., Alswah, Mohamed, Belal, Ahmed, Taghour, Mohammed S., Eissa, Ibrahim H.

“…A new series of 1,2,4‐triazolo[4,3‐c]quinazoline derivatives was designed and synthesized as Topo II inhibitors and DNA intercalators. The cytotoxic effect of…”
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Design, synthesis, and biological activity of novel dithiocarbamate‐methylsulfonyl hybrids as carbonic anhydrase inhibitors by Osmaniye, Derya, Türkeş, Cüneyt, Demir, Yeliz, Özkay, Yusuf, Beydemir, Şükrü, Kaplancıklı, Zafer A.

“…Carbonic anhydrase (CA) enzymes are involved in many physiological events. These enzymes, which contain Zn2+ in their structure, can be easily inhibited by…”
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Pharmacophore-linked pyrazolo[3,4-d]pyrimidines as EGFR-TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies by Gaber, Ahmed A, El-Morsy, Ahmed M, Sherbiny, Farag F, Bayoumi, Ashraf H, El-Gamal, Kamal M, El-Adl, Khaled, Al-Karmalawy, Ahmed A, Ezz Eldin, Rogy R, Saleh, Marwa A, Abulkhair, Hamada S

“…Targeting the epidermal growth factor receptors (EGFRs) with small inhibitor molecules has been validated as a potential therapeutic strategy in cancer…”
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Determination of the inhibition profiles of pyrazolyl–thiazole derivatives against aldose reductase and α‐glycosidase and molecular docking studies by Demir, Yeliz, Taslimi, Parham, Koçyiğit, Ümit M., Akkuş, Musa, Özaslan, Muhammet Serhat, Duran, Hatice Esra, Budak, Yakup, Tüzün, Burak, Gürdere, Meliha B., Ceylan, Mustafa, Taysi, Seyithan, Gülçin, İlhami, Beydemir, Şükrü

“…Aldose reductase (AR) is the first and rate‐limiting enzyme of the polyol pathway, which converts glucose to sorbitol in an NADPH‐dependent reaction…”
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Synthesis, characterization, biological evaluation, and in silico studies of novel 1,3‐diaryltriazene‐substituted sulfathiazole derivatives by Işık, Mesut, Akocak, Süleyman, Lolak, Nabih, Taslimi, Parham, Türkeş, Cüneyt, Gülçin, İlhami, Durgun, Mustafa, Beydemir, Şükrü

“…In the present study, a series of eleven novel 1,3‐diaryltriazene‐substituted sulfathiazole moieties (ST1–11) was synthesized by the reaction of diazonium salt…”
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Sulfonamides incorporating ketene N,S‐acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors by Istrefi, Qëndresa, Türkeş, Cüneyt, Arslan, Mustafa, Demir, Yeliz, Nixha, Arleta R., Beydemir, Şükrü, Küfrevioğlu, Ömer İ.

“…In this study, 15 novel compounds in a series of sulfonamide‐based ketenes (7a–o) were synthesized and characterized using Fourier‐transform infrared…”
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Recent update on antibacterial and antifungal activity of quinoline scaffolds by Dorababu, Atukuri

“…Although most of the heterocycles have been reported to possess a significant pharmacological activity, only a few of them, namely quinoline derivatives, have…”
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Antioxidant Activity, Acetylcholinesterase, and Carbonic Anhydrase Inhibitory Properties of Novel Ureas Derived from Phenethylamines by Aksu, Kadir, Özgeriş, Bünyamin, Taslimi, Parham, Naderi, Ali, Gülçin, İlhami, Göksu, Süleyman

“…A series of ureas derived from phenethylamines were synthesized and evaluated for human carbonic anhydrase (hCA) I and II, acetylcholinesterase (AChE), and…”
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