Search Results - "Archer, E G"

A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study by Schuster, James, Lai, Rose K, Recht, Lawrence D, Reardon, David A, Paleologos, Nina A, Groves, Morris D, Mrugala, Maciej M, Jensen, Randy, Baehring, Joachim M, Sloan, Andrew, Archer, Gary E, Bigner, Darell D, Cruickshank, Scott, Green, Jennifer A, Keler, Tibor, Davis, Thomas A, Heimberger, Amy B, Sampson, John H

“…The epidermal growth factor receptor variant III deletion mutation, EGFRvIII, is expressed in ∼30% of primary glioblastoma and linked to poor long-term…”
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The class III variant of the epidermal growth factor receptor (EGFRvIII): characterization and utilization as an immunotherapeutic target by Wikstrand, C J, Reist, C J, Archer, G E, Zalutsky, M R, Bigner, D D

“…Any immunotherapeutic approach to cancer cell eradication is based upon the specific recognition of neoplastic cells and the sparing of surrounding normal…”
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Subcutaneous Vaccination with Irradiated, Cytokine-Producing Tumor Cells Stimulates CD8$^{+}$ Cell-Mediated Immunity against Tumors Located in the ``Immunologically Privileged" Central Nervous System by Sampson, John H., Archer, Gerald E., Ashley, David M., Fuchs, Herbert E., Hale, Laura P., Dranoff, Glenn, Bigner, Darell D.

“…Vaccination with cytokine-producing tumor cells generates potent immune responses against tumors outside the central nervous system (CNS). The CNS, however, is…”
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Maximization of signal derived from cDNA microarrays by Wildsmith, S E, Archer, G E, Winkley, A J, Lane, P W, Bugelski, P J

“…Microarray technology is a powerful tool for generating expression data on a large number of genes simultaneously. However, as for any assay, it must be…”
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Anti-Synthetic Peptide Antibody Reacting at the Fusion Junction of Deletion-Mutant Epidermal Growth Factor Receptors in Human Glioblastoma by Humphrey, Peter A., Wong, Albert J., Vogelstein, Bert, Zalutsky, Michael R., Fuller, Gregory N., Gerald E.Archer, Friedman, Henry S., Kwatra, Madan M., Bigner, Sandra H., Bigner, Darell D.

“…We have investigated human gliomas that amplify and rearrange the epidermal growth factor receptor gene, with generation of an in-frame deletion mutation of…”
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Interaction of the novel adenosine uptake inhibitor 3-[1-(6,7-diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl]-1,6-dimethyl-2,4(1H,3H)-quinazolinedione hydrochloride (KF24345) with the es and ei subtypes of equilibrative nucleoside transporters by Hammond, James R, Archer, Richard G E

“…Nucleosides such as adenosine, as well as many nucleoside-based drugs, permeate cell membranes via a family of equilibrative nucleoside transporters (ENTs). We…”
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Temozolomide Delivered by Intracerebral Microinfusion is Safe and Efficacious Against Malignant Gliomas in Rats by HEIMBERGER, Amy B, ARCHER, Gary E, MCLENDON, Roger E, HULETTE, Christine, FRIEDMAN, Allan H, FRIEDMAN, Henry S, BIGNER, Darell D, SAMPSON, John H

“…Intracerebral microinfusion (ICM) is an innovative technique of delivering therapeutic agents throughout large portions of the brain that circumvents the…”
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Regional Treatment of Epidermal Growth Factor Receptor vIII-expressing Neoplastic Meningitis with a Single-Chain Immunotoxin, MR-1 by ARCHER, G. E, SAMPSON, J. H, LORIMER, I. A. J, MCLENDON, R. E, KUAN, C.-T, FRIEDMAN, A. H, FRIEDMAN, H. S, PASTAN, I. H, BIGNER, D. D

“…The incidence of neoplastic meningitis is on the rise. Neoplastic meningitis can result from a direct seeding of the neuraxis by primary brain tumors or by…”
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Improved targeting of an anti-epidermal growth factor receptor variant III monoclonal antibody in tumor xenografts after labeling using N-succinimidyl 5-iodo-3-pyridinecarboxylate by REIST, C. J, ARCHER, G. E, WIKSTRAND, C. J, BIGNER, D. D, ZALUTSKY, M. R

“…Monoclonal antibody (mAb) L8A4, specific for the tumor-associated mutant epidermal growth factor receptor variant III (EGFRvII), is internalized and degraded…”
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Radioimmunotherapy of neoplastic meningitis in rats using an α-particle-emitting immunoconjugate by ZALUTSKY, M. R, MCLENDON, R. E, GARG, P. K, ARCHER, G. E, SCHUSTER, J. M, BIGNER, D. D

“…Because of their short range and high linear energy transfer, alpha-particles may be particularly effective in the treatment of neoplastic meningitis…”
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Treatment of Neoplastic Meningitis with Intrathecal Temozolomide by SAMPSON, J. H, ARCHER, G. E, VILLAVICENCIO, A. T, MCLENDON, R. E, FRIEDMAN, A. H, BISHOP, W. R, BIGNER, D. D, FRIEDMAN, H. S

“…Neoplastic meningitis (NM) results from leptomeningeal dissemination of cancers arising within the central nervous system or metastasizing to the leptomeninges…”
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Efficacy of compartmental administration of immunotoxin LMB-1 (B3-LysPE38) in a rat model of carcinomatous meningitis by D D Bigner, G E Archer, R E McLendon, H S Friedman, H E Fuchs, L H Pai, J E Herndon, 2nd, I H Pastan

“…LMB-1 (B3-LysPE38) is an immunotoxin composed of the tumor-reactive monoclonal antibody B3 and a genetically engineered form of Pseudomonas exotoxin…”
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Unarmed, Tumor-Specific Monoclonal Antibody Effectively Treats Brain Tumors by Sampson, John H., Crotty, Laura E., Lee, Samson, Archer, Gary E., Ashley, David M., Wikstrand, Carol J., Hale, Laura P., Small, Clayton, Dranoff, Glenn, Friedman, Allan H., Friedman, Henry S., Bigner, Darell D.

“…The epidermal growth factor receptor (EGFR) is often amplified and rearranged structurally in tumors of the brain, breast, lung, and ovary. The most common…”
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Intrathecal Administration of Single-Chain Immunotoxin, LMB-7 [B3(Fv)- PE38], Produces Cures of Carcinomatous Meningitis in a Rat Model by Pastan, Ira H., Archer, Gary E., McLendon, Roger E., Friedman, Henry S., Fuchs, Herbert E., Wang, Qing-Cheng, Pai, Lee H., Herndon, James, Bigner, Darell D.

“…LMB-7 [B3(Fv)-PE38] is a single-chain immunotoxin constructed from the murine monoclonal antibody B3 and a truncated form of Pseudomonas exotoxin PE38…”
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PET Imaging of Osteosarcoma in Dogs Using a Fluorine-18-Labeled Monoclonal Antibody Fab Fragment by Page, Rodney L, Garg, Pradeep K, Garg, Sudha, Archer, Gary E, Bruland, Oyvind S, Zalutsky, Michael R

“…Four dogs with histologically confirmed osteogenic sarcoma were studied with PET following intravenous injection of the 18F-labeled Fab fragment of TP-3, a…”
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The ECVAM International Validation Study on In Vitro Tests for Skin Corrosivity. 2. Results and Evaluation by the Management Team by Fentem, J.H., Archer, G.E.B., Balls, M., Botham, P.A., Curren, R.D., Earl, L.K., Esdaile, D.J., Holzhütter, H.-G., Liebsch, M.

“…As a follow-up to a prevalidation study on in vitro tests for replacing the in vivo rabbit test for skin corrosivity, an international validation study was…”
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Temozolomide as a vaccine adjuvant in GBM by Sampson, J. H., Aldape, K. D., Gilbert, M. R., Hassenbusch, S. J., Sawaya, R., Schmittling, B., Archer, G. E., Mitchell, D., Bigner, D. D., Reardon, D. A., Heimberger, A. B.

“…Abstract only 2020 Background: Cytotoxic chemotherapy that induces lymphopenia is predicted to ablate the benefits of active antitumor immunization…”
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Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin by He, X, Archer, G E, Wikstrand, C J, Morrison, S L, Zalutsky, M R, Bigner, D D, Batra, S K

“…The murine anti-tenascin monoclonal antibody 81C6, following iodination, has been shown to be an efficient localizing and therapeutic agent in both…”
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Intrathecal busulfan treatment of human neoplastic meningitis in athymic nude rats by ARCHER, G. E, SAMPSON, J. H, FRIEDMAN, H. S, MCLENDON, R. E, FRIEDMAN, A. H, COLVIN, O. M, ROSE, M, SANDS, H, MCCULLOUGH, W, FUCHS, H. E, BIGNER, D. D

“…The current study was designed to evaluate the toxicity and activity of Spartaject Busulfan, a microcrystalline preparation of busulfan, following its…”
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Chimeric anti-tenascin antibody 81C6: Increased tumor localization compared with its murine parent by Zalutsky, Michael R., Archer, Gary E., Garg, Pradeep K., Batra, Surinder K., Bigner, Darell D.

“…When labeled using the Iodogen method, a chimeric antibody composed of the human IgG 2 constant region and the variable regions of murine anti-tenascin 81C6…”
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