Search Results - "Archer, David R"

Platelet biogenesis and functions require correct protein O-glycosylation by Wang, Yingchun, Jobe, Shawn M, Ding, Xiaokun, Choo, Hyojung, Archer, David R, Mi, Rongjuan, Ju, Tongzhong, Cummings, Richard D

“…Platelets express a variety of membrane and secreted glycoproteins, but the importance of glycosylation to platelet functions is poorly understood. To explore…”
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Whole Blood Transcriptome Analysis in Children with Sickle Cell Anemia by Gee, Beatrice E, Pearson, Andrea, Buchanan-Perry, Iris, Simon, Roger P, Archer, David R, Meller, Robert

“…Whole transcriptome RNA-sequencing was performed to quantify RNA expression changes in whole blood samples collected from steady state sickle cell anemia (SCA)…”
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Adhesion molecules and cerebral microvascular hemodynamic abnormalities in sickle cell disease by Abi Rached, Noor Mary, Gbotosho, Oluwabukola T, Archer, David R, Jones, Jayre A, Sterling, Morgan S, Hyacinth, Hyacinth I

“…Cerebrovascular abnormalities are a common feature of sickle cell disease that may be associated with risk of vaso-occlusive pain crises, microinfarcts, and…”
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Albuminuria Is Associated with Endothelial Dysfunction and Elevated Plasma Endothelin-1 in Sickle Cell Anemia by Ataga, Kenneth I, Derebail, Vimal K, Caughey, Melissa, Elsherif, Laila, Shen, Jessica H, Jones, Susan K, Maitra, Poulami, Pollock, David M, Cai, Jianwen, Archer, David R, Hinderliter, Alan L

“…The pathogenesis of albuminuria in SCD remains incompletely understood. We evaluated the association of albuminuria with measures of endothelial function, and…”
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Intestinal barrier dysfunction in murine sickle cell disease is associated with small intestine neutrophilic inflammation, oxidative stress, and dysbiosis by Lewis, Caitlin V., Sellak, Hassan, Sawan, Mariem A., Joseph, Giji, Darby, Trevor M., VanInsberghe, David, Naudin, Crystal R., Archer, David R., Jones, Rheinallt M., Taylor, W. Robert

“…The intestinal microbiome has emerged as a potential contributor to the severity of sickle cell disease (SCD). We sought to determine whether SCD mice exhibit…”
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The use of flow variability analysis to assess the impact of land use change on the paired Plynlimon catchments, mid-Wales by Archer, David R.

“…The impact of land use change on flood response is an issue of considerable practical importance for rural land use management. However firm evidence of…”
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Neural progenitor cell transplants promote long-term functional recovery after traumatic brain injury by Shear, Deborah A., Tate, Matthew C., Archer, David R., Hoffman, Stuart W., Hulce, Verne D., LaPlaca, Michelle C., Stein, Donald G.

“…Studies demonstrating the versatility of neural progenitor cells (NPCs) have recently rekindled interest in neurotransplantation methods aimed at treating…”
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Assessment of Runoff Sensitivity in the Upper Indus Basin to Interannual Climate Variability and Potential Change Using MODIS Satellite Data Products by Forsythe, Nathan, Kilsby, Chris G, Fowler, Hayley J, Archer, David R

“…The Upper Indus Basin (UIB) covers an area of more than 200,000 km2 and has an elevation range from below 1000 to over 8000 m above sea level. Its water…”
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Noscapine Crosses the Blood-Brain Barrier and Inhibits Glioblastoma Growth by LANDEN, Jaren W, HAU, Vincent, MINGSHEN WANG, DAVIS, Thomas, CILIAX, Brian, WAINER, Bruce H, VAN MEIR, Erwin G, GLASS, Johnathan D, JOSHI, Harish C, ARCHER, David R

“…The opium alkaloid noscapine is a commonly used antitussive agent available in Europe, Asia, and South America. Although the mechanism by which it suppresses…”
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Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice by Ghosh, Samit, Ihunnah, Chibueze A, Hazra, Rimi, Walker, Aisha L, Hansen, Jason M, Archer, David R, Owusu-Ansah, Amma T, Ofori-Acquah, Solomon F

“…The prevention of organ damage and early death in young adults is a major clinical concern in sickle cell disease (SCD). However, mechanisms that control adult…”
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The glomerulopathy of sickle cell disease by Ataga, Kenneth I., Derebail, Vimal K., Archer, David R.

“…Sickle cell disease (SCD) produces many structural and functional abnormalities in the kidney, including glomerular abnormalities. Albuminuria is the most…”
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GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease by Oksenberg, Donna, Dufu, Kobina, Patel, Mira P., Chuang, Chihyuan, Li, Zhe, Xu, Qing, Silva‐Garcia, Abel, Zhou, Chengjing, Hutchaleelaha, Athiwat, Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C., Sinha, Uma, Metcalf, Brian W., Archer, David R.

“…Summary A major driver of the pathophysiology of sickle cell disease (SCD) is polymerization of deoxygenated haemoglobin S (HbS), which leads to sickling and…”
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Accelerated atherosclerosis in beta-thalassemia by Hurtado, Julian, Sellak, Hassan, Joseph, Giji, Lewis, Caitlin V, Naudin, Crystal R, Garcia, Sergio, Wodicka, James Robert, Archer, David R, Taylor, W Robert

“…Children with beta-thalassemia (BT) present with an increase in carotid intima-medial thickness, an early sign suggestive of premature atherosclerosis…”
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Plasma metabolomics analysis in sickle cell disease patients with albuminuria – an exploratory study by Elsherif, Laila, Pathmasiri, Wimal, McRitchie, Susan, Archer, David R., Ataga, Kenneth I.

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Body composition and grip strength are improved in transgenic sickle mice fed a high-protein diet by Capers, Patrice L., Hyacinth, Hyacinth I., Cue, Shayla, Chappa, Prasanthi, Vikulina, Tatyana, Roser-Page, Susanne, Weitzmann, M. Neale, Archer, David R., Newman, Gale W., Quarshie, Alexander, Stiles, Jonathan K., Hibbert, Jacqueline M.

“…Key pathophysiology of sickle cell anaemia includes compensatory erythropoiesis, vascular injury and chronic inflammation, which divert amino acids from tissue…”
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Fibronectin promotes survival and migration of primary neural stem cells transplanted into the traumatically injured mouse brain by Tate, Matthew C, Shear, Deborah A, Hoffman, Stuart W, Stein, Donald G, Archer, David R, LaPlaca, Michelle C

“…Multipotential stem cells are an attractive choice for cell therapy after traumatic brain injury (TBI), as replacement of multiple cell types may be required…”
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Higher prevalence of spontaneous cerebral vasculopathy and cerebral infarcts in a mouse model of sickle cell disease by Hyacinth, Hyacinth I, Sugihara, Courtney L, Spencer, Thomas L, Archer, David R, Shih, Andy Y

“…Stroke is a dramatic complication of sickle cell disease (SCD), which is associated with cerebral vasculopathies including moya moya, intravascular thrombi,…”
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Increasing nitric oxide bioavailability fails to improve collateral vessel formation in humanized sickle cell mice by Lewis, Caitlin V., Sellak, Hassan, Hansen, Laura, Joseph, Giji, Hurtado, Julian, Archer, David R., Jun, Ho-Wook, Brown, Lou Ann, Taylor, W. Robert

“…Sickle cell disease (SCD) is associated with repeated bouts of vascular insufficiency leading to organ dysfunction. Deficits in revascularization following…”
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Role of age and neuroinflammation in the mechanism of cognitive deficits in sickle cell disease by Hardy, Raven A, Rached, Noor Abi, Jones, Jayre A, Archer, David R, Hyacinth, Hyacinth I

“…This study aims to determine whether sickle cell mice could recapitulate features of cognitive and neurobehavioral impairment observed in sickle cell patients…”
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Sickle Mice Are Sensitive to Hypoxia/Ischemia-Induced Stroke but Respond to Tissue-Type Plasminogen Activator Treatment by Sun, Yu-Yo, Lee, Jolly, Huang, Henry, Wagner, Mary B, Joiner, Clinton H, Archer, David R, Kuan, Chia-Yi

“…BACKGROUND AND PURPOSE—The effects of lytic stroke therapy in patients with sickle cell anemia are unknown, although a recent study suggested that coexistent…”
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