Search Results - "Archbold, Julia K"

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability by Burrows, Scott R, Chen, Zhenjun, Archbold, Julia K, Tynan, Fleur E, Beddoe, Travis, Kjer-Nielsen, Lars, Miles, John J, Khanna, Rajiv, Moss, Denis J, Liu, Yu Chih, Gras, Stephanie, Kostenko, Lyudmila, Brennan, Rebekah M, Clements, Craig S, Brooks, Andrew G, Purcell, Anthony W, McCluskey, James, Rossjohn, Jamie

“…αβ T cell receptors (TCRs) are genetically restricted to corecognize peptide antigens bound to self-major histocompatibility complex (pMHC) molecules; however,…”
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Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition by Archbold, Julia K, Macdonald, Whitney A, Gras, Stephanie, Ely, Lauren K, Miles, John J, Bell, Melissa J, Brennan, Rebekah M, Beddoe, Travis, Wilce, Matthew C J, Clements, Craig S, Purcell, Anthony W, McCluskey, James, Burrows, Scott R, Rossjohn, Jamie

“…Human leukocyte antigen (HLA) gene polymorphism plays a critical role in protective immunity, disease susceptibility, autoimmunity, and drug hypersensitivity,…”
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The α-proteobacteria Wolbachia pipientis protein disulfide machinery has a regulatory mechanism absent in γ-proteobacteria by Walden, Patricia M, Halili, Maria A, Archbold, Julia K, Lindahl, Fredrik, Fairlie, David P, Inaba, Kenji, Martin, Jennifer L

“…The α-proteobacterium Wolbachia pipientis infects more than 65% of insect species worldwide and manipulates the host reproductive machinery to enable its own…”
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Alloreactivity between Disparate Cognate and Allogeneic pMHC-I Complexes Is the Result of Highly Focused, Peptide-dependent Structural Mimicry by Archbold, Julia K., Macdonald, Whitney A., Miles, John J., Brennan, Rebekah M., Kjer-Nielsen, Lars, McCluskey, James, Burrows, Scott R., Rossjohn, Jamie

“…Our understanding of the molecular mechanisms of T cell alloreactivity remains limited by the lack of systems for which both the T cell receptor allo- and…”
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Reconciling the regulatory role of Munc18 proteins in SNARE-complex assembly by Rehman, Asma, Archbold, Julia K, Hu, Shu-Hong, Norwood, Suzanne J, Collins, Brett M, Martin, Jennifer L

“…Membrane fusion is essential for human health, playing a vital role in processes as diverse as neurotransmission and blood glucose control. Two protein…”
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Human Leukocyte Antigen Class I-Restricted Activation of CD8 + T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity by Chessman, Diana, Kostenko, Lyudmila, Lethborg, Tessa, Purcell, Anthony W., Williamson, Nicholas A., Chen, Zhenjun, Kjer-Nielsen, Lars, Mifsud, Nicole A., Tait, Brian D, Holdsworth, Rhonda, Almeida, Coral Ann, Nolan, David, Macdonald, Whitney A., Archbold, Julia K., Kellerher, Anthony D., Marriott, Debbie, Mallal, Simon, Bharadwaj, Mandvi, Rossjohn, Jamie, McCluskey, James

“…The basis for strong immunogenetic associations between particular human leukocyte antigen (HLA) class I allotypes and inflammatory conditions like Behçet's…”
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Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development by Archbold, Julia K, Flanagan, Jack U, Watkins, Harriet A, Gingell, Joseph J, Hay, Debbie L

“…Secretin family G protein-coupled receptors (GPCRs) are important therapeutic targets for migraine, diabetes, bone disorders, inflammatory disorders and…”
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Calcitonin and calcitonin receptor‐like receptors: common themes with family B GPCRs? by Barwell, James, Gingell, Joseph J, Watkins, Harriet A, Archbold, Julia K, Poyner, David R, Hay, Debbie L

“…The calcitonin receptor (CTR) and calcitonin receptor‐like receptor (CLR) are two of the 15 human family B (or Secretin‐like) GPCRs. CTR and CLR are of…”
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T Cell Allorecognition via Molecular Mimicry by Macdonald, Whitney A., Chen, Zhenjun, Gras, Stephanie, Archbold, Julia K., Tynan, Fleur E., Clements, Craig S., Bharadwaj, Mandvi, Kjer-Nielsen, Lars, Saunders, Philippa M., Wilce, Matthew C.J., Crawford, Fran, Stadinsky, Brian, Jackson, David, Brooks, Andrew G., Purcell, Anthony W., Kappler, John W., Burrows, Scott R., Rossjohn, Jamie, McCluskey, James

“…T cells often alloreact with foreign human leukocyte antigens (HLA). Here we showed the LC13 T cell receptor (TCR), selected for recognition on self-HLA-B…”
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Towards selective lysophospholipid GPCR modulators by Archbold, Julia K, Martin, Jennifer L, Sweet, Matthew J

“…Highlights • We outline the importance of the lysophospholipid GPCRs as drug targets. • We highlight the challenges in developing selective modulators of these…”
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SNARE-ing the structures of Sec1/Munc18 proteins by Archbold, Julia K, Whitten, Andrew E, Hu, Shu-Hong, Collins, Brett M, Martin, Jennifer L

“…•Sec1/Munc18 (SM) proteins are essential for SNARE-mediated membrane fusion.•All SM proteins characterized to date have three domains organized into an…”
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T-cell allorecognition: a case of mistaken identity or déjà vu? by Archbold, Julia K, Macdonald, Whitney A, Burrows, Scott R, Rossjohn, Jamie, McCluskey, James

“…T cells bearing αβ T-cell receptors (TCRs) are selected by a subset of peptide-laden major histocompatibility (pMHC) molecules in the thymus and in the…”
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Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection by Wynn, Katherine K., Fulton, Zara, Cooper, Leanne, Silins, Sharon L., Gras, Stephanie, Archbold, Julia K., Tynan, Fleur E., Miles, John J., McCluskey, James, Burrows, Scott R., Rossjohn, Jamie, Khanna, Rajiv

“…CD8+ T-cell responses to persistent viral infections are characterized by the accumulation of an oligoclonal T-cell repertoire and a reduction in the naive…”
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T cell allorecognition and MHC restriction—A case of Jekyll and Hyde? by Archbold, Julia K., Ely, Lauren K., Kjer-Nielsen, Lars, Burrows, Scott R., Rossjohn, Jamie, McCluskey, James, Macdonald, Whitney A.

“…A great paradox in cellular immunology is how T cell allorecognition exists at high frequencies (up to 10%) despite the stringent requirements of…”
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Polydiscamides B−D from a Marine Sponge Ircinia sp. as Potent Human Sensory Neuron-Specific G Protein Coupled Receptor Agonists by Feng, Yunjiang, Carroll, Anthony R, Pass, David M, Archbold, Julia K, Avery, Vicky M, Quinn, Ronald J

“…Polydiscamides B, C, and D (1−3) were isolated from a sponge Ircinia sp. The structures of 1 to 3 were elucidated by the comparison of their NMR and HRESIMS…”
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Human Leukocyte Antigen Class I-Restricted Activation of CD8 + T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity by Chessman, Diana, Kostenko, Lyudmila, Lethborg, Tessa, Purcell, Anthony W., Williamson, Nicholas A., Chen, Zhenjun, Kjer-Nielsen, Lars, Mifsud, Nicole A., Tait, Brian D., Holdsworth, Rhonda, Almeida, Coral Ann, Nolan, David, Macdonald, Whitney A., Archbold, Julia K., Kellerher, Anthony D., Marriott, Debbie, Mallal, Simon, Bharadwaj, Mandvi, Rossjohn, Jamie, McCluskey, James

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Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs? : Secretin Family (Class B) G Protein-Coupled Receptors - from Molecular to Clinical Perspectives by BARWELL, James, GINGELL, Joseph J, WATKINS, Harriet A, ARCHBOLD, Julia K, POYNER, David R, HAY, Debbie L

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To be gammadelta or not to be gammadelta? Signaling pathways in alphabeta versus gammadelta T cell maturation by Archbold, Julia K

“…Maturation of T cells in the thymus involves input from a number of signaling pathways; their combined input determines whether thymic precursor cells will…”
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The alpha -Proteobacteria Wolbachia pipientis Protein Disulfide Machinery Has a Regulatory Mechanism Absent in gamma -Proteobacteria: e81440 by Walden, Patricia M, Halili, Maria A, Archbold, Julia K, Lindahl, Fredrik, Fairlie, David P, Inaba, Kenji, Martin, Jennifer L

“…The alpha -proteobacterium Wolbachia pipientis infects more than 65% of insect species worldwide and manipulates the host reproductive machinery to enable its…”
Get full text