Search Results - "Arch, J R S"

Some mathematical and technical issues in the measurement and interpretation of open-circuit indirect calorimetry in small animals by Arch, J.R.S, Hislop, D, Wang, S.J.Y, Speakman, J.R

“…Indirect calorimetry is increasingly used to investigate why compounds or genetic manipulations affect body weight or composition in small animals. This review…”
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Thermogenic and metabolic antiobesity drugs: rationale and opportunities by Clapham, J.C, Arch, J.R.S

“…Antiobesity drugs that target peripheral metabolism may avoid some of the problems that have been encountered with centrally acting anorectic drugs. Moreover,…”
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A new, highly selective murine peroxisome proliferator-activated receptor δ agonist increases responsiveness to thermogenic stimuli and glucose uptake in skeletal muscle in obese mice by Ngala, R. A., Stocker, C. J., Roy, A. G., Hislop, D., Wargent, E., Bell, R., Hassall, D. G., Harling, J. D., Billin, A. N., Willson, T. M., Arch, J. R. S., Cawthorne, M. A.

“…Aim: We investigated how GW800644, the first pharmacologically selective murine peroxisome proliferator‐activated receptor δ (PPARδ) agonist, affects energy…”
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Inhibition of 11β-hydroxysteroid dehydrogenase type 1 reduces food intake and weight gain but maintains energy expenditure in diet-induced obese mice by WANG, S. J. Y, BIRTLES, S, DE SCHOOLMEESTER, J, SWALES, J, MOODY, G, HISLOP, D, O'DOWD, J, SMITH, D. M, TURNBULL, A. V, ARCH, J. R. S

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Leanness in postnatally nutritionally programmed rats is associated with increased sensitivity to leptin and a melanocortin receptor agonist and decreased sensitivity to neuropeptide Y by Stocker, C J, Wargent, E T, Martin-Gronert, M S, Cripps, R L, O'Dowd, J F, Zaibi, M S, Cottrell, E C, Mercer, J G, Duncan, J S, Cawthorne, M A, Ozanne, S E, Arch, J R S

“…Background: Pups of normally nourished dams that are cross-fostered after birth to dams fed a low-protein (8% by weight) diet (postnatal low protein (PLP))…”
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Modulation of susceptibility to weight gain and insulin resistance in low birthweight rats by treatment of their mothers with leptin during pregnancy and lactation by STOCKER, C, O'DOWD, J, MORTON, N. M, WARGENT, E, SENNITT, M. V, HISLOP, D, GLUND, S, SECKL, J. R, ARCH, J. R. S, CAWTHORNE, M. A

“…To investigate whether administration of leptin to rats during pregnancy and lactation affects placental 11beta-hydroxysteroid dehydrogenase (11beta-HSD2)…”
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Comment on: Schmidt MI, Duncan BB, Vigo A et al. (2006) Leptin and incident type 2 diabetes: risk or protection? Diabetologia 49:2086–2096 by Arch, J. R. S.

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Lessons in obesity from transgenic animals by Arch, J R S

“…Many genetic manipulations have created models of obesity, leanness or resistance to dietary obesity in mice, often providing insights into molecular…”
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Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone by Wargent, E., Stocker, C., Augstein, P., Heinke, P., Meyer, A., Hoffmann, T., Subramanian, A., Sennitt, M. V., Demuth, H.-U., Arch, J. R. S., Cawthorne, M. A.

“…Aim:  The aim of this study was to investigate the effect of long‐term treatment with the dipeptidyl peptidase inhibitor P32/98 and its combination with…”
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Atypical β -adrenoceptor on brown adipocytes as target for anti-obesity drugs by Arch, J. R. S, Ainsworth, A. T, Cawthorne, M. A, Piercy, V, Sennitt, M. V, Thody, V. E, Wilson, C, Wilson, S

“…Recent studies suggest that thermogenesis in brown adipose tissue has an important role in the regulation of energy balance. Thermogenesis is effected by…”
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C-terminal fragments of ACTH stimulate feeding in fasted rats by Al-Barazanji, K A, Miller, J E, Rice, S Q, Arch, J R, Chambers, J K

“…Peptides derived from pro-opiomelanocortin, including alpha-MSH and ACTH, play important roles in the regulation of feeding. We investigated the central effect…”
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Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and β 2 ‐adrenoceptor mechanisms by Ngala, R A, O'Dowd, J, Wang, S J, Agarwal, A, Stocker, C, Cawthorne, M A, Arch, J R S

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Hypothalamic orexin expression: modulation by blood glucose and feeding by CAI, X. J, WIDDOWSON, P. S, HARROLD, J, WILSON, S, BUCKINGHAM, R. E, ARCH, J. R. S, TADAYYON, M, CLAPHAM, J. C, WILDING, J, WILLIAMS, G

“…Hypothalamic orexin expression: modulation by blood glucose and feeding. X J Cai , P S Widdowson , J Harrold , S Wilson , R E Buckingham , J R Arch , M…”
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SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats by Rodgers, R. J., Halford, J. C. G., Nunes de Souza, R. L., Canto de Souza, A. L., Piper, D. C., Arch, J. R. S., Upton, N., Porter, R. A., Johns, A., Blundell, J. E.

“…Intracerebroventricular (i.c.v.) administration of the novel hypothalamic neuropeptide orexin‐A stimulates food intake in rats, and delays the onset of…”
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Immunohistochemical identification of the beta(3)-adrenoceptor in intact human adipocytes and ventricular myocardium: effect of obesity and treatment with ephedrine and caffeine by De Matteis, R, Arch, J R S, Petroni, M L, Ferrari, D, Cinti, S, Stock, M J

“…To investigate whether the beta(3)-adrenoceptor could be identified by immunohistochemistry in intact human white and brown adipocytes and other human tissues,…”
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The rate of substrate cycling between fructose 6-phosphate and fructose 1,6-bisphosphate in skeletal muscle by Challiss, R A, Arch, J R, Newsholme, E A

“…Substrate cycling of fructose 6-phosphate through reactions catalysed by 6-phosphofructokinase and fructose-1,6-bisphosphatase was measured in skeletal muscles…”
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Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and beta2-adrenoceptor mechanisms by Ngala, R A, O'Dowd, J, Wang, S J, Agarwal, A, Stocker, C, Cawthorne, M A, Arch, J R S

“…Picomolar concentrations of the beta3-adrenoceptor agonist BRL37344 stimulate 2-deoxyglucose uptake in soleus muscle via undefined receptors. Higher…”
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Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and [beta]2-adrenoceptor mechanisms by Ngala, R A, O'dowd, J, Wang, S J, Agarwal, A, Stocker, C, Cawthorne, M A, Arch, J R S

“…BACKGROUND AND PURPOSE: Picomolar concentrations of the beta3-adrenoceptor agonist BRL37344 stimulate 2-deoxyglucose uptake in soleus muscle via undefined…”
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Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and β2‐adrenoceptor mechanisms by Ngala, R A, O'Dowd, J, Wang, S J, Agarwal, A, Stocker, C, Cawthorne, M A, Arch, J R S

“…Background and purpose: Picomolar concentrations of the β3‐adrenoceptor agonist BRL37344 stimulate 2‐deoxyglucose uptake in soleus muscle via undefined…”
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Substrate supply for thermogenesis induced by the beta-adrenoceptor agonist BRL 26830A by Wilson, S, Thurlby, P L, Arch, J R

“…The nature of the substrate that fuels the thermogenic response to the novel beta-adrenoceptor agonist BRL 26830A has been investigated. Respiratory quotient…”
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