Search Results - "Arceci, R J"

Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance by Bradshaw, D M, Arceci, R J

“…For cytotoxic agents to have an effect on tumor cells, drugs must first be transported into the cell, potentially be metabolized to an active form, and…”
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Clinical significance of P-glycoprotein in multidrug resistance malignancies by ARCECI, R. J

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The histiocytoses: The fall of the Tower of Babel by Arceci, R.J.

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Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart by ARCECI, R. J, KING, A. A. J, SIMON, M. C, ORKIN, S. H, WILSON, D. B

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The Multidrug Resistance (mdr1) Gene Product Functions as an ATP Channel by Abraham, Edward H., Prat, Adriana G., Gerweck, Leo, Seneveratne, Tara, Arceci, Robert J., Kramer, Robert, Guidotti, Guido, Cantiello, Horacio F.

“…The multidrug resistance (mdr1) gene product, P-glycoprotein, is responsible for the ATP-dependent extrusion of a variety of compounds, including…”
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Controversies and new approaches to treatment of Langerhans cell histiocytosis by Arceci, R J, Brenner, M K, Pritchard, J

“…There continues to be genuine ambivalence as to whether Langerhans cell histiocytosis (LCH) is a primary neoplastic or immuno-dysregulatory disorder. Treatment…”
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Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype by ARCECI, R. J, STIEGLITZ, K, BIERER, B. E

“…The multidrug-resistant (MDR) phenotype is characterized in vitro by the resistance displayed by cell lines to a broad spectrum of natural product cytotoxic…”
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The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues by Croop, J M, Raymond, M, Haber, D, Devault, A, Arceci, R J, Gros, P, Housman, D E

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Progesterone Interacts with P-Glycoprotein in Multidrug-resistant Cells and in the Endometrium of Gravid Uterus by Yang, C P H, DePinho, S G, Greenberger, L M, Arceci, R J, Horwitz, S B

“…P-Glycoprotein (P-GP) plays a pivotal role in maintaining the multidrug-resistant (MDR) phenotype. This membrane glycoprotein is overproduced in MDR cells and…”
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Temporal Expression and Location of Colony-Stimulating Factor 1 (CSF-1) and Its Receptor in the Female Reproductive Tract are Consistent with CSF-1-Regulated Placental Development by Arceci, Robert J., Shanahan, Frances, Stanley, E. Richard, Pollard, Jeffrey W.

“…During pregnancy the mouse uterine epithelial synthesis of the mononuclear phagocyte growth factor designated colony-stimulating factor 1 (CSF-1) is regulated…”
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The Gene Encoding Multidrug Resistance is Induced and Expressed at High Levels during Pregnancy in the Secretory Epithelium of the Uterus by Arceci, Robert J., Croop, James M., Horwitz, Susan Band, Housman, David

“…A survey of the expression of the multidrug-resistance gene (mdr) in mouse tissues revealed that a mdr mRNA species is expressed at extremely high levels in…”
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Correction of autoimmune lymphoproliferative syndrome by bone marrow transplantation by SLEIGHT, B. J, PRASAD, V. S, DELAAT, C, STEELE, P, BALLARD, E, ARCECI, R. J, SIDMAN, C. L

“…This report describes a child with a severe phenotype of autoimmune lymphoproliferative syndrome (ALPS) who developed progressive disease requiring stem cell…”
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Long-term results of children with acute myeloid leukemia: a report of three consecutive Phase III trials by the Children's Cancer Group: CCG 251, CCG 213 and CCG 2891 by Smith, F O, Alonzo, T A, Gerbing, R B, Woods, W G, Arceci, R J

“…The Children's Cancer Group (CCG) conducted three Phase III prospective clinical trials for children with de novo acute myeloid leukemia between the years 1979…”
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Proliferation-associated SNF2-like gene (PASG) : A SNF2 family member altered in leukemia by LEE, D. W, KEJIAN ZHANG, NING, Z.-Q, RAABE, E. H, TINTNER, S, WIELAND, R, WILKINS, B. J, KIM, J. M, BLOUGH, R. I, ARCECI, R. J

“…To identify genes involved in cell growth and/or apoptosis in leukemia, differential display was used to identify mRNAs that showed altered expression levels…”
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mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies by BUSCHMAN, E, ARCECI, R. J, CROOP, J. M, MINGXIN CHE, ARIAS, I. M, HOUSMAN, D. E, GROS, P

“…We have produced antibodies specific for the three P-glycoprotein (P-gp) isoforms encoded by the mouse mdr1, mdr2, and mdr3 genes. The anti-Mdr2 and anti-Mdr3…”
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Allelotype of pediatric rhabdomyosarcoma by VISSER, M, SIJMONS, C, BRAS, J, ARCECI, R. J, GODFRIED, M, VALENTIJN, L. J, VOUTE, P. A, BAAS, F

“…An allelotype covering all autosomes was constructed for the embryonal form of childhood rhabdomyosarcoma (ERMS) in order to identify regions encompassing…”
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Activating Mutations of c-Kit at Codon 816 Confer Drug Resistance in Human Leukemia Cells by Ning, Zhi-Qiang, Li, Jin, Arceci, Robert J.

“…An improved understanding of how leukemia cells grow and become resistant to treatment remains critical for developing more effective therapies. We have…”
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Irradiated B7-1 transduced primary acute myelogenous leukemia (AML) cells can be used as therapeutic vaccines in murine AML by DUNUSSI-JOANNOPOULOS, K, WEINSTEIN, H. J, NICKERSON, P. W, STROM, T. B, BURAKOFF, S. J, CROOP, J. M, ARCECI, R. J

“…Recent studies have shown that tumor cells genetically modified by transduction of B7-1, a natural ligand for the T-cell costimulatory molecules CD28 and…”
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Localized expression of the atrial natriuretic factor gene during cardiac embryogenesis by Zeller, R, Bloch, K D, Williams, B S, Arceci, R J, Seidman, C E

“…Expression of the gene encoding atrial natriuretic factor (ANF) during mouse cardiac embryogenesis was studied using in situ hybridization to histologic…”
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Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line by Baas, F, Jongsma, A P, Broxterman, H J, Arceci, R J, Housman, D, Scheffer, G L, Riethorst, A, van Groenigen, M, Nieuwint, A W, Joenje, H

“…Two different mechanisms that contribute to multidrug resistance (MDR) were found in derivatives of the human squamous lung cancer cell line SW-1573. The…”
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