Search Results - "Arce, Pablo M."

Optimization of pyrimidinol antioxidants as mitochondrial protective agents: ATP production and metabolic stability by Chevalier, Arnaud, Alam, Mohammad Parvez, Khdour, Omar M., Schmierer, Margaret, Arce, Pablo M., Cripe, Cameron D., Hecht, Sidney M.

“…[Display omitted] Previously we described a novel series of pyrimidinol antioxidants and their structural optimization as potential therapeutic agents for…”
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Cytoprotective pyridinol antioxidants as potential therapeutic agents for neurodegenerative and mitochondrial diseases by Alam, Mohammad Parvez, Khdour, Omar M., Arce, Pablo M., Chen, Yana, Roy, Basab, Johnson, Walter G., Dey, Sriloy, Hecht, Sidney M.

“…[Display omitted] As part of our ongoing efforts to identify compounds having potential utility in treating neurodegenerative and mitochondrial disorders, a…”
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Antineoplastic Agents. 599. Total Synthesis of Dolastatin 16 by Pettit, George R, Smith, Thomas H, Arce, Pablo M, Flahive, Erik J, Anderson, Collin R, Chapuis, Jean-Charles, Xu, Jun-Ping, Groy, Thomas L, Belcher, Paul E, Macdonald, Christian B

“…The first 23-step total synthesis of the cyclodepsipeptide dolastatin 16 (1) has been achieved. Synthesis of the dolaphenvaline and dolamethylleuine amino acid…”
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Efficient Asymmetric Synthesis of Tryptophan Analogues Having Useful Photophysical Properties by Talukder, Poulami, Chen, Shengxi, Arce, Pablo M, Hecht, Sidney M

“…Two new fluorescent probes of protein structure and dynamics have been prepared by concise asymmetric syntheses using the Schöllkopf chiral auxiliary. The…”
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Antineoplastic Agents. 600. From the South Pacific Ocean to the Silstatins by Pettit, George R, Arce, Pablo M, Chapuis, Jean-Charles, Macdonald, Christian B

“…The recent advances in the development of antibody and other drug conjugates for targeted cancer treatment have further increased the need for powerful cancer…”
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Novel Antioxidants Protect Mitochondria from the Effects of Oligomeric Amyloid Beta and Contribute to the Maintenance of Epigenome Function by Mastroeni, Diego, Khdour, Omar M, Arce, Pablo M, Hecht, Sidney M, Coleman, Paul D

“…Alzheimer’s disease is associated with metabolic deficits and reduced mitochondrial function, with the latter due to the effects of oligomeric amyloid beta…”
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Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria by Duveau, Damien Y., Arce, Pablo M., Schoenfeld, Robert A., Raghav, Nidhi, Cortopassi, Gino A., Hecht, Sidney M.

“…Analogues of mitoQ and idebenone were synthesized to define the structural elements that support oxygen consumption in the mitochondrial respiratory chain…”
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Effects of alkyl side chain modification of coenzyme Q₁₀ on mitochondrial respiratory chain function and cytoprotection by Fash, David M, Khdour, Omar M, Sahdeo, Sunil J, Goldschmidt, Ruth, Jaruvangsanti, Jennifer, Dey, Sriloy, Arce, Pablo M, Collin, Valérie C, Cortopassi, Gino A, Hecht, Sidney M

“…The effect of the alkyl side chain length of coenzyme Q₁₀ on mitochondrial respiratory chain function has been investigated by the use of synthetic ubiquinone…”
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Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases by Goldschmidt, Ruth, Arce, Pablo M., Khdour, Omar M., Collin, Valérie C., Dey, Sriloy, Jaruvangsanti, Jennifer, Fash, David M., Hecht, Sidney M.

“…Two new aza analogues of the neuroprotective agent idebenone have been synthesized and characterized. Their antioxidant activity, and ability to augment ATP…”
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Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection by Arce, Pablo M., Goldschmidt, Ruth, Khdour, Omar M., Madathil, Manikandadas M., Jaruvangsanti, Jennifer, Dey, Sriloy, Fash, David M., Armstrong, Jeffrey S., Hecht, Sidney M.

“…Selected pyridinol analogues of the experimental neuroprotective drug idebenone have been synthesized and evaluated as antioxidants capable of preserving…”
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An Optimized Pyrimidinol Multifunctional Radical Quencher by Khdour, Omar M, Arce, Pablo M, Roy, Basab, Hecht, Sidney M

“…A series of aza analogues (4–9) of the experimental neuroprotective drug idebenone (1) have been prepared and evaluated for their ability to attenuate…”
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A Strategy for Suppressing Redox Stress within Mitochondria by Arce, Pablo M., Khdour, Omar M., Goldschmidt, Ruth, Armstrong, Jeffrey S., Hecht, Sidney M.

“…An aza analogue (1) of the experimental neuroprotective drug idebenone has been prepared and evaluated. The compound quenches lipid peroxidation more…”
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Microalgae and probiotic bacteria as biofloc inducers in a hyper-intensive Pacific white shrimp (Penaeus vannamei) culture by Jimenez-Ordaz, Francisco J, Cadena-Roa, Marco A, Pacheco-Vega, Juan M, Rojas-Contreras, Maurilia, Tovar-Ramirez, Dariel, Arce-Amezquita, Pablo M

“…Biofloc systems in Pacific white shrimp (Penaeus vannamei) culture generate floccules that remove wastes, and hence, biofloc formation is promoted for shrimp…”
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Effects of alkyl side chain modification of coenzyme Q 10 on mitochondrial respiratory chain function and cytoprotection by Fash, David M., Khdour, Omar M., Sahdeo, Sunil J., Goldschmidt, Ruth, Jaruvangsanti, Jennifer, Dey, Sriloy, Arce, Pablo M., Collin, Valérie C., Cortopassi, Gino A., Hecht, Sidney M.

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Synthesis of Multifunctional Radical Quenchers (MRQ's) by Arce Amezquita, Pablo M

“…Mitochondria produce most of the ATP needed for the cell as an energy source. It is well known that cellular respiration results in oxidative damage to the…”
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Synthesis of Multifunctional Radical Quenchers (MRQ's) by Arce Amezquita, Pablo M

“…Mitochondria produce most of the ATP needed for the cell as an energy source. It is well known that cellular respiration results in oxidative damage to the…”
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