The effect of one injection of Depo-Provera® on the human vaginal epithelium and cervical ectopy

Two studies in rhesus monkeys have shown that progesterone implants, Depo-Provera® and Norplant®, were associated with vaginal thinning. Progesterone implants have also been associated with an increased risk of simian immunodeficiemcy virus (SIV) acquisition. This study in 16 women was done to asses...

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Bibliographic Details
Published in:	Contraception (Stoneham) Vol. 60; no. 1; pp. 15 - 24
Main Authors:	Mauck, Christine K, Callahan, Marianne Morse, Baker, Jay, Arbogast, Kathleen, Veazey, Ron, Stock, Richard, Pan, Zhiying, Morrison, Charles S, Chen-Mok, Mario, Archer, David F, Gabelnick, Henry L
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-07-1999 Elsevier Science
Subjects:	Adult AIDS/HIV Biological and medical sciences Biopsy Birth control Body Weight cervix Cervix Uteri - drug effects Cervix Uteri - pathology contraceptive Contraceptive Agents, Female - administration & dosage Contraceptive Agents, Female - therapeutic use Depo-Provera ectopy epithelium Epithelium - drug effects Epithelium - pathology estradiol Estradiol - blood Female Gynecology. Andrology. Obstetrics Hormonal contraception Humans Image Processing, Computer-Assisted injectable Injections, Intramuscular Langerhans Cells - drug effects Medical sciences medroxyprogesterone acetate Medroxyprogesterone Acetate - administration & dosage Medroxyprogesterone Acetate - blood Medroxyprogesterone Acetate - therapeutic use Menstrual Cycle Photography Population progesterone Progesterone - blood Regression Analysis Statistics, Nonparametric vagina Vagina - drug effects Vagina - pathology ectopy cervix injectable vagina Depo-Provera medroxyprogesterone acetate progesterone biopsy epithelium contraceptive estradiol Thickness Human Controlled release form Medroxyprogesterone Vagina Female Uterine cervix Ectopia Epithelium Intramuscular administration Progestagen Depo-provera > side effects Americas Genitalia United States Biology Contraception Medroxyprogesterone Acetate > side effects Cervix Family Planning North America Genitalia, Female Diseases Urogenital System Contraceptive Agents > side effects Northern America Developed Countries Uterus Contraceptive Agents, Progestin > side effects Vaginal Abnormalities Research Report Physiology Cervical Effects Virginia Contraceptive Agents, Female > side effects
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Summary:	Two studies in rhesus monkeys have shown that progesterone implants, Depo-Provera® and Norplant®, were associated with vaginal thinning. Progesterone implants have also been associated with an increased risk of simian immunodeficiemcy virus (SIV) acquisition. This study in 16 women was done to assess vaginal epithelial thickness and number of cell layers from biopsies taken in the untreated follicular and luteal phases, and at 1 month and 3 months after administration of Depo-Provera. There was no significant change over time in either parameter from biopsies obtained in the luteal phase compared with those at either time after Depo-Provera administration. There was also no change in the mean number of Langerhans cells in vaginal wall specimens and no change in cervical ectopy. It appears that women do not respond to exogenous progestins with the dramatic vaginal thinning seen in rhesus monkeys.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0010-7824 1879-0518
DOI:	10.1016/S0010-7824(99)00058-X