Search Results - "Arbiza, Leonardo"

Contrasting X-Linked and Autosomal Diversity across 14 Human Populations by Arbiza, Leonardo, Gottipati, Srikanth, Siepel, Adam, Keinan, Alon

“…Contrasting the genetic diversity of the human X chromosome (X) and autosomes has facilitated understanding historical differences between males and females…”
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Inference of natural selection from interspersed genomic elements based on polymorphism and divergence by Gronau, Ilan, Arbiza, Leonardo, Mohammed, Jaaved, Siepel, Adam

“…Complete genome sequences contain valuable information about natural selection, but this information is difficult to access for short, widely scattered…”
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NRE: a tool for exploring neutral loci in the human genome by Arbiza, Leonardo, Zhong, Elaine, Keinan, Alon

“…Analyzing regions of the genome where genetic variation is free from the confounding effects of natural selection is essential for many population genetic…”
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Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations by Rodriguez-Flores, Juan L, Fakhro, Khalid, Agosto-Perez, Francisco, Ramstetter, Monica D, Arbiza, Leonardo, Vincent, Thomas L, Robay, Amal, Malek, Joel A, Suhre, Karsten, Chouchane, Lotfi, Badii, Ramin, Al-Nabet Al-Marri, Ajayeb, Abi Khalil, Charbel, Zirie, Mahmoud, Jayyousi, Amin, Salit, Jacqueline, Keinan, Alon, Clark, Andrew G, Crystal, Ronald G, Mezey, Jason G

“…An open question in the history of human migration is the identity of the earliest Eurasian populations that have left contemporary descendants. The Arabian…”
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Positive selection, relaxation, and acceleration in the evolution of the human and chimp genome by Arbiza, Leonardo, Dopazo, Joaquín, Dopazo, Hernán

“…For years evolutionary biologists have been interested in searching for the genetic bases underlying humanness. Recent efforts at a large or a complete genomic…”
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From genes to functional classes in the study of biological systems by Al-Shahrour, Fátima, Arbiza, Leonardo, Dopazo, Hernán, Huerta-Cepas, Jaime, Mínguez, Pablo, Montaner, David, Dopazo, Joaquín

“…With the popularization of high-throughput techniques, the need for procedures that help in the biological interpretation of results has increased enormously…”
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P472: Highly scalable pharmacogenomic panel testing with hybrid capture and long-read sequencing by Gonzaludo, Nina, Kingan, Sarah, Harting, John, Baybayan, Primo, Zhang, Siyuan, Han, Tina, Arbiza, Leonardo, Yang, Yao, Hammond, Nathan, Scott, Stuart

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Sexual selection drives weak positive selection in protamine genes and high promoter divergence, enhancing sperm competitiveness by Martin-Coello, Juan, Dopazo, Hernán, Arbiza, Leonardo, Ausió, Juan, Roldan, Eduardo R.S., Gomendio, Montserrat

“…Phenotypic adaptations may be the result of changes in gene structure or gene regulation, but little is known about the evolution of gene expression. In…”
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Population genomic analysis of 962 whole genome sequences of humans reveals natural selection in non-coding regions by Yu, Fuli, Lu, Jian, Liu, Xiaoming, Gazave, Elodie, Chang, Diana, Raj, Srilakshmi, Hunter-Zinck, Haley, Blekhman, Ran, Arbiza, Leonardo, Van Hout, Cris, Morrison, Alanna, Johnson, Andrew D, Bis, Joshua, Cupples, L Adrienne, Psaty, Bruce M, Muzny, Donna, Yu, Jin, Gibbs, Richard A, Keinan, Alon, Clark, Andrew G, Boerwinkle, Eric

“…Whole genome analysis in large samples from a single population is needed to provide adequate power to assess relative strengths of natural selection across…”
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Natural selection on functional modules, a genome-wide analysis by Serra, François, Arbiza, Leonardo, Dopazo, Joaquín, Dopazo, Hernán

“…Classically, the functional consequences of natural selection over genomes have been analyzed as the compound effects of individual genes. The current paradigm…”
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Evolutionary Genomics of Genes Involved in Olfactory Behavior in the Drosophila melanogaster Species Group by Lavagnino, Nicolás, Serra, François, Arbiza, Leonardo, Dopazo, Hermán, Hasson, Esteban

“…Previous comparative genomic studies of genes involved in olfactory behavior in Drosophila focused only on particular gene families such as odorant receptor…”
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Cis -regulatory elements and human evolution by Siepel, Adam, Arbiza, Leonardo

“…Modification of gene regulation has long been considered an important force in human evolution, particularly through changes to cis -regulatory elements (CREs)…”
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Genome-wide inference of natural selection on human transcription factor binding sites by Arbiza, Leonardo, Gronau, Ilan, Aksoy, Bulent A, Hubisz, Melissa J, Gulko, Brad, Keinan, Alon, Siepel, Adam

“…Adam Siepel and colleagues find that natural selection has exerted a significant influence on transcription factor binding sites in the human lineage using a…”
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Abstract 2098: Twist Fast Hybridization targeted methylation sequencing: a tunable target enrichment solution for methylation detection by Graham, Brenton I., Arbiza, Leonardo, Butcher, Kristin, Chen, Siyuan, Gantt, Richard, Gude, Sabina, Nugent, Rebecca, Thompson, Christina, Zeitoun, Ramsey

“…DNA methylation is a genetic occurrence that plays a principal role in the epigenetic regulation of gene expression. Genome wide association studies (GWAS)…”
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Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing by Gottipati, Srikanth, Arbiza, Leonardo, Siepel, Adam, Clark, Andrew G, Keinan, Alon

“…Alon Keinan and colleagues estimate the ratio of genetic diversity on the X chromosome to that on the autosome (X/A) on the basis of whole-genome sequencing of…”
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Strong Constraint on Human Genes Escaping X-Inactivation Is Modulated by their Expression Level and Breadth in Both Sexes by Slavney, Andrea, Arbiza, Leonardo, Clark, Andrew G, Keinan, Alon

“…In eutherian mammals, X-linked gene expression is normalized between XX females and XY males through the process of X chromosome inactivation (XCI). XCI…”
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Clustered mutations in hominid genome evolution are consistent with APOBEC3G enzymatic activity by Pinto, Yishay, Gabay, Orshay, Arbiza, Leonardo, Sams, Aaron J, Keinan, Alon, Levanon, Erez Y

“…The gradual accumulation of mutations by any of a number of mutational processes is a major driving force of divergence and evolution. Here, we investigate a…”
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Abstract 3544: High performance multiplexed targeted enrichment sequencing from FFPE tissues by Consugar, Mark, Arbiza, Leonardo, Butcher, Kristin, Chen, Siyuan, Chilton, Hutson, Gantt, Richard, Hasin-Brumshtein, Yehudit, Laugharn, Jim, Simon, Jayne, Thomann, Ulrich, Thompson, Christina, Zeitoun, Ramsey

“…Library construction for Next-Generation Sequencing (NGS) using formalin-fixed paraffin-embedded (FFPE) samples offers unique challenges in acquiring…”
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PupaSuite: finding functional single nucleotide polymorphisms for large-scale genotyping purposes by Conde, Lucía, Vaquerizas, Juan M, Dopazo, Hernán, Arbiza, Leonardo, Reumers, Joke, Rousseau, Frederic, Schymkowitz, Joost, Dopazo, Joaquín

“…We have developed a web tool, PupaSuite, for the selection of single nucleotide polymorphisms (SNPs) with potential phenotypic effect, specifically oriented to…”
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Genome-wide heterogeneity of nucleotide substitution model fit by Arbiza, Leonardo, Patricio, Mateus, Dopazo, Hernán, Posada, David

“…At a genomic scale, the patterns that have shaped molecular evolution are believed to be largely heterogeneous. Consequently, comparative analyses should use…”
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