Search Results - "Arbiser, Jack L."

Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair by Shook, Brett A, Wasko, Renee R, Rivera-Gonzalez, Guillermo C, Salazar-Gatzimas, Emilio, López-Giráldez, Francesc, Dash, Biraja C, Muñoz-Rojas, Andrés R, Aultman, Krystal D, Zwick, Rachel K, Lei, Vivian, Arbiser, Jack L, Miller-Jensen, Kathryn, Clark, Damon A, Hsia, Henry C, Horsley, Valerie

“…During tissue repair, myofibroblasts produce extracellular matrix (ECM) molecules for tissue resilience and strength. Altered ECM deposition can lead to tissue…”
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Honokiol, a multifunctional antiangiogenic and antitumor agent by Fried, Levi E, Arbiser, Jack L

“…Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. It is accompanied by other related polyphenols, including magnolol, with which it…”
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Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3 by Pillai, Vinodkumar B., Samant, Sadhana, Sundaresan, Nagalingam R., Raghuraman, Hariharasundaram, Kim, Gene, Bonner, Michael Y., Arbiser, Jack L., Walker, Douglas I., Jones, Dean P., Gius, David, Gupta, Mahesh P.

“…Honokiol (HKL) is a natural biphenolic compound derived from the bark of magnolia trees with anti-inflammatory, anti-oxidative, anti-tumour and neuroprotective…”
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Gentian Violet: a 19th century drug re-emerges in the 21st century by Maley, Alexander M., Arbiser, Jack L.

“…Gentian violet (GV) has a long and varied history as a medicinal agent. Historically used as an antibacterial and antifungal, recent reports have shown its…”
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Antioxidants: Positive or Negative Actors? by Salehi, Bahare, Martorell, Miquel, Arbiser, Jack L, Sureda, Antoni, Martins, Natália, Maurya, Pawan Kumar, Sharifi-Rad, Mehdi, Kumar, Pradeep, Sharifi-Rad, Javad

“…The term "antioxidant" is one of the most confusing definitions in biological/medical sciences. In chemistry, "antioxidant" is simply conceived "a compound…”
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Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling by Kang, Hee-Bum, Fan, Jun, Lin, Ruiting, Elf, Shannon, Ji, Quanjiang, Zhao, Liang, Jin, Lingtao, Seo, Jae Ho, Shan, Changliang, Arbiser, Jack L., Cohen, Cynthia, Brat, Daniel, Miziorko, Henry M., Kim, Eunhee, Abdel-Wahab, Omar, Merghoub, Taha, Fröhling, Stefan, Scholl, Claudia, Tamayo, Pablo, Barbie, David A., Zhou, Lu, Pollack, Brian P., Fisher, Kevin, Kudchadkar, Ragini R., Lawson, David H., Sica, Gabriel, Rossi, Michael, Lonial, Sagar, Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Boggon, Titus J., He, Chuan, Kang, Sumin, Chen, Jing

“…Many human cancers share similar metabolic alterations, including the Warburg effect. However, it remains unclear whether oncogene-specific metabolic…”
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MAVS is a double-edged sword by Huang, Christina, Arbiser, Jack L.

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A key role for NOX4 in epithelial cell death during development of lung fibrosis by Carnesecchi, Stephanie, Deffert, Christine, Donati, Yves, Basset, Olivier, Hinz, Boris, Preynat-Seauve, Olivier, Guichard, Cecile, Arbiser, Jack L, Banfi, Botond, Pache, Jean-Claude, Barazzone-Argiroffo, Constance, Krause, Karl-Heinz

“…The pathogenesis of pulmonary fibrosis is linked to oxidative stress, possibly generated by the reactive oxygen species (ROS) generating NADPH oxidase NOX4…”
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SIRT3 activation promotes enteric neurons survival and differentiation by Balasubramaniam, Arun, Li, Ge, Ramanathan, Anita, Mwangi, Simon Musyoka, Hart, C. Michael, Arbiser, Jack L., Srinivasan, Shanthi

“…Enteric neuron degeneration has been observed during aging, and in individuals with metabolic dysfunction including obesity and diabetes. Honokiol, a naturally…”
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Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition by Trotta, Andrew P., Gelles, Jesse D., Serasinghe, Madhavika N., Loi, Patrick, Arbiser, Jack L., Chipuk, Jerry E.

“…The mitochondrial network is a major site of ATP production through the coupled integration of the electron transport chain (ETC) with oxidative…”
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Honokiol Bis-Dichloroacetate Is a Selective Allosteric Inhibitor of the Mitochondrial Chaperone TRAP1 by Sanchez-Martin, Carlos, Menon, Daniela, Moroni, Elisabetta, Ferraro, Mariarosaria, Masgras, Ionica, Elsey, Justin, Arbiser, Jack L, Colombo, Giorgio, Rasola, Andrea

“…TNF receptor-associated protein 1 (TRAP1), the mitochondrial paralog of the heat shock protein 90 (Hsp90) family of molecular chaperones, is required for…”
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SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis by Akamata, Kaname, Wei, Jun, Bhattacharyya, Mitra, Cheresh, Paul, Bonner, Michael Y, Arbiser, Jack L, Raparia, Kirtee, Gupta, Mahesh P, Kamp, David W, Varga, John

“…Constitutive fibroblast activation is responsible for organ fibrosis in fibrotic disorders including systemic sclerosis (SSc), but the underlying mechanisms…”
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Dibenzolium induces apoptosis and inhibits epithelial-mesenchymal transition (EMT) in bladder cancer cell lines by Jotatsu, Yura, Arbiser, Jack L., Moriwaki, Michika, Hirata, Yuto, Takeda, Shunya, Takada, Ichiro, Chen, Kuan-Chou, Sung, Shian-Ying, Shigemura, Katsumi

“…Bladder cancer treatments are highly aggressive and have strong side effects. Safer and more effective treatments are needed. In this study, Dibenzolium (DIB),…”
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Honokiol is a potent scavenger of superoxide and peroxyl radicals by Dikalov, Sergey, Losik, Tanya, Arbiser, Jack L.

“…Honokiol, a compound extracted from Magnolia officinalis, has antitumor and antiangiogenic properties in several tumor models in vivo. Among the downstream…”
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Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity by Diano, Sabrina, Liu, Zhong-Wu, Jeong, Jin Kwon, Dietrich, Marcelo O, Ruan, Hai-Bin, Kim, Esther, Suyama, Shigetomo, Kelly, Kaitlin, Gyengesi, Erika, Arbiser, Jack L, Belsham, Denise D, Sarruf, David A, Schwartz, Michael W, Bennett, Anton M, Shanabrough, Marya, Mobbs, Charles V, Yang, Xiaoyong, Gao, Xiao-Bing, Horvath, Tamas L

“…Tamas Horvath and his colleagues show that in states of obesity activation of the transcription factor PPAR-γ in POMC neurons occurs, resulting in an increase…”
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Palladium based nanoparticles for the treatment of advanced melanoma by Elsey, Justin, Bubley, Jeffrey A., Zhu, Lei, Rao, Shikha, Sasaki, Maiko, Pollack, Brian P., Yang, Lily, Arbiser, Jack L.

“…IGF1R and CD44 are overexpressed in most advanced melanomas so we designed chemotherapeutic nanoparticles to target those receptors…”
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R-Propranolol Has Broad-Spectrum Anti-Coronavirus Activity and Suppresses Factors Involved in Pathogenic Angiogenesis by Thaler, Melissa, Salgado-Benvindo, Clarisse, Leijs, Anouk, Tas, Ali, Ninaber, Dennis K, Arbiser, Jack L, Snijder, Eric J, van Hemert, Martijn J

“…The SARS-CoV-2 pandemic highlighted the need for broad-spectrum antivirals to increase our preparedness. Patients often require treatment by the time that…”
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Honokiol Acts as a Potent Anti-Fibrotic Agent in the Liver through Inhibition of TGF-β1/SMAD Signaling and Autophagy in Hepatic Stellate Cells by Kataoka, Seita, Umemura, Atsushi, Okuda, Keiichiro, Taketani, Hiroyoshi, Seko, Yuya, Nishikawa, Taichiro, Yamaguchi, Kanji, Moriguchi, Michihisa, Kanbara, Yoshihiro, Arbiser, Jack L, Shima, Toshihide, Okanoue, Takeshi, Itoh, Yoshito

“…Chronic liver injury may result in hepatic fibrosis, which can progress to cirrhosis and eventually liver failure. There are no drugs that are specifically…”
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Targeting the duality of cancer by Arbiser, Jack L., Bonner, Michael Y., Gilbert, Linda C.

“…Cancer is the second leading cause of death in the United States, and is an increasing cause of death in the developing world. While there is great…”
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Skin Barrier Function: The Interplay of Physical, Chemical, and Immunologic Properties by Baker, Paola, Huang, Christina, Radi, Rakan, Moll, Samara B, Jules, Emmanuela, Arbiser, Jack L

“…An intact barrier function of the skin is important in maintaining skin health. The regulation of the skin barrier depends on a multitude of molecular and…”
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