Search Results - "Araujo, Aline D."

Late‐Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins by Araujo, Aline D., Nguyen, Huy T., Fairlie, David P.

“…The conventional S‐alkylation of cysteine relies upon using activated electrophiles. Here we demonstrate high‐yielding and selective S‐alkylation and…”
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Tuning Electrostatic and Hydrophobic Surfaces of Aromatic Rings to Enhance Membrane Association and Cell Uptake of Peptides by Araujo, Aline D., Hoang, Huy N., Lim, Junxian, Mak, Jeffrey Y. W., Fairlie, David P.

“…Aromatic groups are key mediators of protein–membrane association at cell surfaces, contributing to hydrophobic effects and π‐membrane interactions. Here we…”
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Comparative α-Helicity of Cyclic Pentapeptides in Water by de Araujo, Aline D., Hoang, Huy N., Kok, W. Mei, Diness, Frederik, Gupta, Praveer, Hill, Timothy A., Driver, Russell W., Price, David A., Liras, Spiros, Fairlie, David P.

“…Helix‐constrained polypeptides have attracted great interest for modulating protein–protein interactions (PPI). It is not known which are the most effective…”
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Fortified Coiled Coils: Enhancing Mechanical Stability with Lactam or Metal Staples by López‐García, Patricia, Araujo, Aline D., Bergues‐Pupo, Ana E., Tunn, Isabell, Fairlie, David P., Blank, Kerstin G.

“…Coiled coils (CCs) are powerful supramolecular building blocks for biomimetic materials, increasingly used for their mechanical properties. Here, we introduce…”
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Helix Nucleation by the Smallest Known α-Helix in Water by Hoang, Huy N., Driver, Russell W., Beyer, Renée L., Hill, Timothy A., D. de Araujo, Aline, Plisson, Fabien, Harrison, Rosemary S., Goedecke, Lena, Shepherd, Nicholas E., Fairlie, David P.

“…Cyclic pentapeptides (e.g. Ac‐(cyclo‐1,5)‐[KAXAD]‐NH2; X=Ala, 1; Arg, 2) in water adopt one α‐helical turn defined by three hydrogen bonds. NMR structure…”
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Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl‑1 Proteins by D. de Araujo, Aline, Lim, Junxian, Wu, Kai-Chen, Xiang, Yibin, Good, Andrew C, Skerlj, Renato, Fairlie, David P

“…A 26-residue peptide BimBH3 binds indiscriminately to multiple oncogenic Bcl2 proteins that regulate apoptosis of cancer cells. Specific inhibition of the…”
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Modulating Oxytocin Activity and Plasma Stability by Disulfide Bond Engineering by Muttenthaler, Markus, Andersson, Asa, de Araujo, Aline D, Dekan, Zoltan, Lewis, Richard J, Alewood, Paul F

“…Disulfide bond engineering is an important approach to improve the metabolic half-life of cysteine-containing peptides. Eleven analogues of oxytocin were…”
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Tuning Electrostatic and Hydrophobic Surfaces of Aromatic Rings to Enhance Membrane Association and Cell Uptake of Peptides by Araujo, Aline D., Hoang, Huy N., Lim, Junxian, Mak, Jeffrey Y. W., Fairlie, David P.

“…Aromatic groups are key mediators of protein–membrane association at cell surfaces, contributing to hydrophobic effects and π‐membrane interactions. Here we…”
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Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake by de Araujo, Aline D, Lim, Junxian, Wu, Kai-Chen, Hoang, Huy N, Nguyen, Huy T, Fairlie, David P

“…Cyclic peptides that modulate protein-protein interactions can be valuable therapeutic candidates if they can be delivered intact to their target proteins in…”
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Front Cover: Late‐Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins (ChemBioChem 10/2021) by Araujo, Aline D., Nguyen, Huy T., Fairlie, David P.

“…Linear and branched hydrocarbon chains may be appended or crosslinked at selected cysteine positions in unprotected peptides and proteins. The method involves…”
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p-Nitrobenzyl protection for cysteine and selenocysteine: A more stable alternative to the acetamidomethyl group by Muttenthaler, Markus, Ramos, Yesica Garcia, Feytens, Debby, de Araujo, Aline D., Alewood, Paul F.

“…This study evaluated the acidic lability of the acetamidomethyl (Acm), trimethylacetamidomethyl (Tacm), and the p‐nitrobenzyl (pNB) as protecting groups for…”
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Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability by Perry, Samuel R, Hill, Timothy A, de Araujo, Aline D, Hoang, Huy N, Fairlie, David P

“…Most protein-protein interactions occur inside cells. Peptides can inhibit protein-protein interactions but tend not to enter cells. We systematically compare…”
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Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling by Plisson, Fabien, Hill, Timothy A., Mitchell, Justin M., Hoang, Huy N., de Araujo, Aline D., Xu, Weijun, Cotterell, Adam, Edmonds, David J., Stanton, Robert V., Derksen, David R., Loria, Paula M., Griffith, David A., Price, David A., Liras, Spiros, Fairlie, David P.

“…Glucagon-like peptide (GLP-1) is an endogenous hormone that induces insulin secretion from pancreatic islets and modified forms are used to treat diabetes…”
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Mechanische Verstärkung von Coiled Coils mit Lactam und Histidin‐Metall‐Klammern by López‐García, Patricia, de Araujo, Aline D., Bergues‐Pupo, Ana E., Tunn, Isabell, Fairlie, David P., Blank, Kerstin G.

“…Coiled Coils (CCs) sind vielversprechende Proteinbausteine für biomimetische Materialien, die aufgrund ihrer mechanischen Eigenschaften vermehrt genutzt…”
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Mechanische Verstärkung von Coiled Coils mit Lactam und Histidin‐Metall‐Klammern by López‐García, Patricia, Araujo, Aline D., Bergues‐Pupo, Ana E., Tunn, Isabell, Fairlie, David P., Blank, Kerstin G.

“…Coiled Coils (CCs) sind vielversprechende Proteinbausteine für biomimetische Materialien, die aufgrund ihrer mechanischen Eigenschaften vermehrt genutzt…”
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Helix Nucleation by the Smallest Known [alpha]-Helix in Water by Hoang, Huy N, Driver, Russell W, Beyer, Renée L, Hill, Timothy A, D.deAraujo, Aline, Plisson, Fabien, Harrison, Rosemary S, Goedecke, Lena, Shepherd, Nicholas E, Fairlie, David P

“…Cyclic pentapeptides (e.g. Ac-(cyclo-1,5)-[KAXAD]-NH2; X=Ala, 1; Arg, 2) in water adopt one [alpha]-helical turn defined by three hydrogen bonds. NMR structure…”
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Comparative [alpha]-Helicity of Cyclic Pentapeptides in Water by deAraujo, Aline D, Hoang, Huy N, Kok, W Mei, Diness, Frederik, Gupta, Praveer, Hill, Timothy A, Driver, Russell W, Price, David A, Liras, Spiros, Fairlie, David P

“…Helix-constrained polypeptides have attracted great interest for modulating protein-protein interactions (PPI). It is not known which are the most effective…”
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A Mild Method for the Preparation of 8-Substituted Xanthines from 5,6-Diaminouracils by W. Joachim Demnitz, F., D. de Araujo, Aline, Bacher, Edmond, A. Santos, Douglas

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Comparative α-Helicity of Cyclic Pentapeptides in Water by de Araujo, Aline D., Hoang, Huy N., Kok, W. Mei, Diness, Frederik, Gupta, Praveer, Hill, Timothy A., Driver, Russell W., Price, David A., Liras, Spiros, Fairlie, David P.

“…Helix‐constrained polypeptides have attracted great interest for modulating protein–protein interactions (PPI). It is not known which are the most effective…”
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Improved regionalization of streamflow by use of the streamflow equivalent of precipitation as an explanatory variable by Pruski, Fernando Falco, Nunes, Aline de Araújo, Pruski, Pedro Lopes, Rodriguez, Renata del Giudice

“…► A new explanatory variable for streamflow regionalization studies is proposed. ► Improvements in the statistical adjustment and in hydrologic behavior were…”
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