Search Results - "Arasaradnam, Ramesh P."

Bile acid diarrhoea and metabolic changes after cholecystectomy: a prospective case-control study by Farrugia, Alexia, Williams, Nigel, Khan, Saboor, P Arasaradnam, Ramesh

“…Bile acid diarrhoea (BAD) can occur due to disruption to the enterohepatic circulation such as following cholecystectomy. However, the mechanism behind this is…”
Get full text

Microbial imbalance in inflammatory bowel disease patients at different taxonomic levels by Alam, Mohammad Tauqeer, Amos, Gregory C A, Murphy, Andrew R J, Murch, Simon, Wellington, Elizabeth M H, Arasaradnam, Ramesh P

“…Inflammatory bowel disease (IBD), is a debilitating group of chronic diseases including Crohn's Disease (CD) and ulcerative colitis (UC), which causes…”
Get full text

Non-Invasive Detection and Staging of Colorectal Cancer Using a Portable Electronic Nose by Tyagi, Heena, Daulton, Emma, Bannaga, Ayman S, Arasaradnam, Ramesh P, Covington, James A

“…Electronic noses (e-nose) offer potential for the detection of cancer in its early stages. The ability to analyse samples in real time, at a low cost, applying…”
Get full text

Tackling climate change is a global medical community responsibility by Moloo, Husein, Hunter, Arnagretta, Arasaradnam, Ramesh P

Get full text

Exploratory Study Using Urinary Volatile Organic Compounds for the Detection of Hepatocellular Carcinoma by Bannaga, Ayman S, Tyagi, Heena, Daulton, Emma, Covington, James A, Arasaradnam, Ramesh P

“…Hepatocellular carcinoma (HCC) biomarkers are lacking in clinical practice. We therefore explored the pattern and composition of urinary volatile organic…”
Get full text

Role of tissue microenvironment resident adipocytes in colon cancer by Tabuso, Maria, Homer-Vanniasinkam, Shervanthi, Adya, Raghu, Arasaradnam, Ramesh P

“…Colorectal cancer(CRC) is a multifactorial disease characterized by several genetic and epigenetic alterations occurring in epithelial cells. It is…”
Get full text

Ustekinumab is effective and safe for ulcerative colitis through 2 years of maintenance therapy by Panaccione, Remo, Danese, Silvio, Sandborn, William J., O'Brien, Christopher D., Zhou, Yiying, Zhang, Hongyan, Adedokun, Omoniyi J., Tikhonov, Ilia, Targan, Stephan, Abreu, Maria T., Hisamatsu, Tadakazu, Scherl, Ellen J., Leong, Rupert W., Rowbotham, David S., Arasaradnam, Ramesh P., Sands, Bruce E., Marano, Colleen

“…Summary Background The ongoing UNIFI long‐term extension evaluates subcutaneous ustekinumab for moderate‐to‐severe ulcerative colitis (UC) from weeks 44…”
Get full text

Efficacy and Safety of Maintenance Ustekinumab for Ulcerative Colitis Through 3 Years: UNIFI Long-term Extension by Abreu, Maria T, Rowbotham, David S, Danese, Silvio, Sandborn, William J, Miao, Ye, Zhang, Hongyan, Tikhonov, Ilia, Panaccione, Remo, Hisamatsu, Tadakazu, Scherl, Ellen J, Leong, Rupert W, Arasaradnam, Ramesh P, Afif, Waqqas, Peyrin-Biroulet, Laurent, Sands, Bruce E, Marano, Colleen

“…Abstract Background and Aims The UNIFI long-term extension [LTE] study reports the efficacy and safety of subcutaneous 90 mg ustekinumab through 3 years of…”
Get full text

Detection of colorectal cancer (CRC) by urinary volatile organic compound analysis by Arasaradnam, Ramesh P, McFarlane, Michael J, Ryan-Fisher, Courtenay, Westenbrink, Erik, Hodges, Phoebe, Hodges, Paula, Thomas, Matthew G, Chambers, Samantha, O'Connell, Nicola, Bailey, Catherine, Harmston, Christopher, Nwokolo, Chuka U, Bardhan, Karna D, Covington, James A

“…Colorectal cancer (CRC) is a leading cause of cancer related death in Europe and the USA. There is no universally accepted effective non-invasive screening…”
Get full text

Study of capsule endoscopy delivery at scale through enhanced artificial intelligence‐enabled analysis (the CESCAIL study) by Lei, Ian Io, Tompkins, Katie, White, Elizabeth, Watson, Angus, Parsons, Nicholas, Noufaily, Angela, Segui, Santi, Wenzek, Hagen, Badreldin, Rawya, Conlin, Abby, Arasaradnam, Ramesh P.

“…Aim Lower gastrointestinal (GI) diagnostics have been facing relentless capacity constraints for many years, even before the COVID‐19 era. Restrictions from…”
Get full text

The pathophysiology of bile acid diarrhoea: differences in the colonic microbiome, metabolome and bile acids by Sagar, Nidhi M., Duboc, Henri, Kay, Gemma L., Alam, Mohammad T., Wicaksono, Alfian N., Covington, James A., Quince, Christopher, Kokkorou, Margarita, Svolos, Vaios, Palmieri, Lola J., Gerasimidis, Konstantinos, Walters, Julian R. F., Arasaradnam, Ramesh P.

“…Bile acid diarrhoea (BAD) is a common disorder resulting from increased loss of bile acids (BAs), overlapping irritable bowel syndrome with diarrhoea (IBS-D)…”
Get full text

Breath Analysis Using eNose and Ion Mobility Technology to Diagnose Inflammatory Bowel Disease-A Pilot Study by Tiele, Akira, Wicaksono, Alfian, Kansara, Jiten, Arasaradnam, Ramesh P, Covington, James A

“…Early diagnosis of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), remains a clinical challenge with current…”
Get full text

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing by Greaves, Laura C, Nooteboom, Marco, Elson, Joanna L, Tuppen, Helen A L, Taylor, Geoffrey A, Commane, Daniel M, Arasaradnam, Ramesh P, Khrapko, Konstantin, Taylor, Robert W, Kirkwood, Thomas B L, Mathers, John C, Turnbull, Douglass M

“…Age-related decline in the integrity of mitochondria is an important contributor to the human ageing process. In a number of ageing stem cell populations, this…”
Get full text

An improved machine learning pipeline for urinary volatiles disease detection: Diagnosing diabetes by Martinez-Vernon, Andrea S, Covington, James A, Arasaradnam, Ramesh P, Esfahani, Siavash, O'Connell, Nicola, Kyrou, Ioannis, Savage, Richard S

“…The measurement of disease biomarkers in easily-obtained bodily fluids has opened the door to a new type of non-invasive medical diagnostics. New technologies…”
Get full text

Clinical utility of colon capsule endoscopy: a moving target? by Jalayeri Nia, Gohar, Arasaradnam, Ramesh P., Koulaouzidis, Anastasios

“…The purpose of this article is to provide an overview of white light colon capsule endoscopy’s current clinical application, concentrating on its most recent…”
Get full text

Urinary Volatiles and Chemical Characterisation for the Non-Invasive Detection of Prostate and Bladder Cancers by Tyagi, Heena, Daulton, Emma, Bannaga, Ayman S, Arasaradnam, Ramesh P, Covington, James A

“…Bladder cancer (BCa) and prostate cancer (PCa) are some of the most common cancers in the world. In both BCa and PCa, the diagnosis is often confirmed with an…”
Get full text

Exploring how microbiome signatures change across inflammatory bowel disease conditions and disease locations by Amos, Gregory C. A., Sergaki, Chrysi, Logan, Alastair, Iriarte, Rolland, Bannaga, Ayman, Chandrapalan, Subashini, Wellington, Elizabeth M. H., Rijpkema, Sjoerd, Arasaradnam, Ramesh P.

“…Understanding the variables that influence microbiome studies is critical for successful translational research. Inflammatory bowel disease (IBD) is a complex…”
Get full text

Field cancerisation in colorectal cancer:A new frontier or pastures past? by Patel, Abhilasha, Tripathi, Gyanendra, Gopalakrishnan, Kishore, Williams, Nigel, Arasaradnam, Ramesh P

“…Despite considerable advances in our understanding of cancer biology, early diagnosis of colorectal cancer remains elusive. Based on the adenoma-carcinoma…”
Get full text

Differentiating coeliac disease from irritable bowel syndrome by urinary volatile organic compound analysis--a pilot study by Arasaradnam, Ramesh P, Westenbrink, Eric, McFarlane, Michael J, Harbord, Ruth, Chambers, Samantha, O'Connell, Nicola, Bailey, Catherine, Nwokolo, Chuka U, Bardhan, Karna D, Savage, Richard, Covington, James A

“…Coeliac disease (CD), a T-cell-mediated gluten sensitive enteropathy, affects ∼ 1% of the UK population and can present with wide ranging clinical features,…”
Get full text

Minimal Gluten Exposure Alters Urinary Volatile Organic Compounds in Stable Coeliac Disease by McFarlane, Michael, Arasaradnam, Ramesh P, Reed, Beryl, Daulton, Emma, Wicaksono, Alfian, Tyagi, Heena, Covington, James A, Nwokolo, Chuka

“…Coeliac disease (CD) patients are distinguishable from healthy individuals via urinary volatile organic compounds (VOCs) analysis. We exposed 20 stable CD…”
Get full text