Search Results - "Arasa Verge, Emili A."
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Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy
Published in Frontiers in oncology (02-06-2022)“…Cisplatin induces DNA crosslinks that are highly cytotoxic. Hence, platinum complexes are frequently used in the treatment of a broad range of cancers…”
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POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells
Published in Cell reports (Cambridge) (29-11-2022)“…Polymerase theta (POLθ) is an error-prone DNA polymerase whose loss is synthetically lethal in cancer cells bearing breast cancer susceptibility proteins 1 and…”
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Journal Article