Search Results - "Arantes, R."

Enhancement of CRISPR/Cas12a trans-cleavage activity using hairpin DNA reporters by Rossetti, Marianna, Merlo, Rosa, Bagheri, Neda, Moscone, Danila, Valenti, Anna, Saha, Aakash, Arantes, Pablo R, Ippodrino, Rudy, Ricci, Francesco, Treglia, Ida, Delibato, Elisabetta, van der Oost, John, Palermo, Giulia, Perugino, Giuseppe, Porchetta, Alessandro

“…Abstract The RNA programmed non-specific (trans) nuclease activity of CRISPR-Cas Type V and VI systems has opened a new era in the field of nucleic acid-based…”
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GPU-Enhanced DFTB Metadynamics for Efficiently Predicting Free Energies of Biochemical Systems by Kumar, Anshuman, Arantes, Pablo R, Saha, Aakash, Palermo, Giulia, Wong, Bryan M

“…Metadynamics calculations of large chemical systems with ab initio methods are computationally prohibitive due to the extensive sampling required to simulate…”
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An alpha-helical lid guides the target DNA toward catalysis in CRISPR-Cas12a by Saha, Aakash, Ahsan, Mohd, Arantes, Pablo R., Schmitz, Michael, Chanez, Christelle, Jinek, Martin, Palermo, Giulia

“…CRISPR-Cas12a is a powerful RNA-guided genome-editing system that generates double-strand DNA breaks using its single RuvC nuclease domain by a sequential…”
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Fighting COVID-19 Using Molecular Dynamics Simulations by Arantes, Pablo R, Saha, Aakash, Palermo, Giulia

“…Molecular dynamics simulations revealed a promising immune target on the SARS-CoV-2 spike protein, proposing novel strategies for vaccine development…”
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Reducing Indigenous Oral Health Inequalities: A Review from 5 Nations by Tiwari, T., Jamieson, L., Broughton, J., Lawrence, H.P., Batliner, T.S., Arantes, R., Albino, J.

“…Indigenous populations around the world experience a disproportionate burden in terms of oral diseases and conditions. These inequalities are likely due to a…”
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New design strategies for ultra-specific CRISPR-Cas13a-based RNA detection with single-nucleotide mismatch sensitivity by Molina Vargas, Adrian M, Sinha, Souvik, Osborn, Raven, Arantes, Pablo R, Patel, Amun, Dewhurst, Stephen, Hardy, Dwight J, Cameron, Andrew, Palermo, Giulia, O’Connell, Mitchell R

“…Abstract An increasingly pressing need for clinical diagnostics has required the development of novel nucleic acid-based detection technologies that are…”
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Unveiling the RNA-mediated allosteric activation discloses functional hotspots in CRISPR-Cas13a by Sinha, Souvik, Molina Vargas, Adrian M, Arantes, Pablo R, Patel, Amun, O’Connell, Mitchell R, Palermo, Giulia

“…Abstract Cas13a is a recent addition to the CRISPR-Cas toolkit that exclusively targets RNA, which makes it a promising tool for RNA detection. It utilizes a…”
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Enhanced specificity mutations perturb allosteric signaling in CRISPR-Cas9 by Nierzwicki, Lukasz, East, Kyle W, Morzan, Uriel N, Arantes, Pablo R, Batista, Victor S, Lisi, George P, Palermo, Giulia

“…CRISPR-Cas9 (clustered regularly interspaced short palindromic repeat and associated Cas9 protein) is a molecular tool with transformative genome editing…”
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Ethanol and caffeine consumption modulates the expression of miRNAs in the cerebellum and plasma of UChB rats by Rossetto, I.M.U., Cagnon, V.H.A., Lizarte, F.S.N., Tirapelli, L.F., Tirapelli, D.P.C., Arantes, R.M.S., Chuffa, L.G.A., Martinez, F.E., Martinez, M.

“…The present study aimed to verify changes in cerebellar and plasmatic expression of miRNAs after the chronic consumption of ethanol and caffeine in the UChB…”
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Analysis of Epstein-Barr Virus (EBV) and PD-L1 Expression in Nasopharyngeal Carcinoma Patients in a Non-Endemic Region by Dias, Josiane M, Santana, Iara V V, da Silva, Vinicius D, Carvalho, André L, Arantes, Lidia M R B

“…The purpose of this study was to evaluate the status of Epstein-Barr virus (EBV) infection and the expression of programmed cell death ligand-1 (PD-L1) in…”
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Osseointegration of zirconia and titanium implants in a rabbit tibiae model evaluated by microtomography, histomorphometry and fluorochrome labeling analyses by Martins, R., Cestari, T. M., Arantes, R. V. N., Santos, P. S., Taga, R., Carbonari, M. J., Oliveira, R. C.

“…Objectives This study compares the osseointegration of machined‐zirconia implants containing yttria (M‐Y‐TZP) with machined (M‐Ti) and resorbable blast media…”
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Reversibility of Lung Collapse and Hypoxemia in Early Acute Respiratory Distress Syndrome by Borges, Joao B, Okamoto, Valdelis N, Matos, Gustavo F. J, Caramez, Maria P. R, Arantes, Paula R, Barros, Fabio, Souza, Ciro E, Victorino, Josue A, Kacmarek, Robert M, Barbas, Carmen S. V, Carvalho, Carlos R. R, Amato, Marcelo B. P

“…The hypothesis that lung collapse is detrimental during the acute respiratory distress syndrome is still debatable. One of the difficulties is the lack of an…”
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Intelligent Supernovae Classification Systems in the KDUST context by Arantes Filho, LuÍs R, Rosa, Reinaldo R, GuimarÃes, Lamartine N F

“…With the advent of large astronomical surveys plus multi-messenger astronomy, both automatic detection and classification of Type Ia supernovae have been…”
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Co-expression of TNF receptors 1 and 2 on melanomas facilitates soluble TNF-induced resistance to MAPK pathway inhibitors by Sander, Cindy A, Rush, Elizabeth A, Shi, Jian, Arantes, Lidia M R B, Tesi, Raymond J, Ross, Mark A, Calderon, Michael J, Watkins, Simon C, Kirkwood, John M, Ferris, Robert L, Butterfield, Lisa H, Vujanovic, Lazar

“…The effectiveness of MAPK pathway inhibitors (MAPKi) used to treat patients with BRAF-mutant melanoma is limited by a range of resistance mechanisms, including…”
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Galactose epimerase deficiency: lessons from the GalNet registry by Derks, Britt, Demirbas, Didem, Arantes, Rodrigo R., Banford, Samantha, Burlina, Alberto B., Cabrera, Analía, Chiesa, Ana, Couce, M. Luz, Dionisi-Vici, Carlo, Gautschi, Matthias, Grünewald, Stephanie, Morava, Eva, Möslinger, Dorothea, Scholl-Bürgi, Sabine, Skouma, Anastasia, Stepien, Karolina M., Timson, David J., Berry, Gerard T., Rubio-Gozalbo, M. Estela

“…Background Galactose epimerase (GALE) deficiency is a rare hereditary disorder of galactose metabolism with only a few cases described in the literature. This…”
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Characteristics of Lactobacillus and Gardnerella vaginalis from women with or without bacterial vaginosis and their relationships in gnotobiotic mice by TEIXEIRA, G. S, CARVALHO, F. P, ARANTES, R. M. E, NUNES, A. C, MOREIRA, J. L. S, MENDONCA, M, ALMEIDA, R. B, FARIAS, L. M, CARVALHO, M. A. R, NICOLI, J. R

“…The objectives of the present study were to evaluate in vitro the production of antagonistic compounds against Gardnerella vaginalis by Lactobacillus strains…”
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Serum miRNAs are differentially altered by ethanol and caffeine consumption in rats by Martinez, M, Rossetto, I. M. U, Arantes, R. M. S, Lizarte, F. S. N, Tirapelli, L. F, Tirapelli, D. P. C, Chuffa, L. G. A, Martinez, F. E

“…Alcoholism is a multifactorial disease with high risk for dependence determined by genetic background, environmental factors and neuroadaptations. The…”
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Classification of cardiorespiratory fitness using the six-minute walk test in adults: Comparison with cardiopulmonary exercise testing by Dourado, V.Z., Nishiaka, R.K., Simões, M.S.M.P., Lauria, V.T., Tanni, S.E., Godoy, I., Gagliardi, A.R.T., Romiti, M., Arantes, R.L.

“…The six-minute walk test (6MWT) distance could facilitate the assessment of cardiorespiratory fitness (CRF) in clinical practice as recommended. We aimed to…”
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Origin of step-like and lobate seafloor features along the continental shelf off Rio de Janeiro State, Santos basin-Brazil by Reis, A.T., Maia, R.M.C., Silva, C.G., Rabineau, M., Guerra, J.V., Gorini, C., Ayres, A., Arantes-Oliveira, R., Benabdellouahed, M., Simões, I., Tardin, R.

“…A combined analysis of seismic and morphological features identified in a set of high-resolution seismic reflection and bathymetric data, shows a systematic…”
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Twisting and swiveling domain motions in Cas9 to recognize target DNA duplexes, make double-strand breaks, and release cleaved duplexes by Wang, Jimin, Arantes, Pablo R, Ahsan, Mohd, Sinha, Souvik, Kyro, Gregory W, Maschietto, Federica, Allen, Brandon, Skeens, Erin, Lisi, George P, Batista, Victor S, Palermo, Giulia

“…The CRISPR-associated protein 9 (Cas9) has been engineered as a precise gene editing tool to make double-strand breaks. CRISPR-associated protein 9 binds the…”
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