Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals

Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions. To analyze the epidemiological and clinical characteristi...

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Bibliographic Details
Published in:	Anais brasileiros de dermatología Vol. 92; no. 5; pp. 661 - 667
Main Authors:	Arantes, Luana Bernardes, Reis, Carmélia Santiago, Novaes, Alice Garbi, Carvalho, Marta Rodrigues de, Göttems, Leila Bernarda Donato, Novaes, Maria Rita Carvalho Garbi
Format:	Journal Article
Language:	English
Published:	Brazil Sociedade Brasileira de Dermatologia 01-09-2017
Subjects:	Adolescent Adult Aged Brazil - epidemiology Child Child, Preschool Cross-Sectional Studies DERMATOLOGY Drug eruptions Epidemiology Female Hospitals, Public Humans Infant Infant, Newborn Investigation Male Middle Aged Retrospective Studies Stevens-Johnson syndrome Stevens-Johnson Syndrome - drug therapy Stevens-Johnson Syndrome - epidemiology Stevens-Johnson Syndrome - etiology Young Adult Drug eruptions Stevens-Johnson syndrome Epidemiology
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Summary:	Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions. To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil. Retrospective, cross-sectional and descriptive study, in which data were collected referring to patients hospitalized in the public healthcare system of the Federal District from 1999 to 2014. Results: Between 1999 and 2014, 86 cases of hospitalized patients with diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis in the Federal District were reported. The majority of patients were women; the most affected age group was 0 to 10 years. Patients older than 60 years (elderly) represent 6.98% of the cases. Most patients admitted to the referral hospital were discharged. However, occurrence of deaths exceeded that of discharge in elderly patients. There is fragility in the registry of hospitalization of patients, both in the hospital information system and in the medical records of the reference hospital. There is a need for greater production and better dissemination of information on the incidence of adverse drug reactions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0365-0596 1806-4841 1806-4841 0365-0596
DOI:	10.1590/abd1806-4841.20176610