Search Results - "Aranha, Cecília M. S. Q."
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Histamine H3 receptor and cholinesterases as synergistic targets for cognitive decline: Strategies to the rational design of multitarget ligands
Published in Chemical biology & drug design (01-08-2021)“…The role of histamine and acetylcholine in cognitive functions suggests that compounds able to increase both histaminergic and cholinergic neurotransmissions…”
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Evaluation of the histamine H3 receptor antagonists from LINS01 series as cholinesterases inhibitors: Enzymatic and modeling studies
Published in Chemical biology & drug design (01-11-2022)“…Histamine is involved in several central nervous system processes including cognition. In the last years, H3 receptor (H3R) antagonists have been widely…”
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Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H3 and dopamine D3 receptors
Published in Bioorganic & medicinal chemistry (15-01-2023)“…[Display omitted] Multitargeting ligands on enzymes and receptors may generate a profile for a potential treatment of cognitive impairment. Considering this, a…”
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4
Histamine H 3 receptor and cholinesterases as synergistic targets for cognitive decline: strategies to the rational design of multitarget ligands
Published in Chemical biology & drug design (01-08-2021)“…The role of histamine and acetylcholine in cognitive functions suggests that compounds able to increase both histaminergic and cholinergic neurotransmissions…”
Get full text
Journal Article -
5
Evaluation of the histamine H 3 receptor antagonists from LINS01 series as cholinesterases inhibitors: Enzymatic and modeling studies
Published in Chemical biology & drug design (01-11-2022)“…Histamine is involved in several central nervous system processes including cognition. In the last years, H receptor (H R) antagonists have been widely…”
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Journal Article -
6
Profiling of LINS01 compounds at human dopamine D2 and D3 receptors
Published in Journal of chemical sciences (Bangalore, India) (01-12-2020)“…Histamine and dopamine neuronal pathways display interesting overlapping in the CNS, especially in the limbic areas, making them very attractive to designing…”
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Toward New Therapeutics for Visceral Leishmaniasis: Efficacy and Mechanism of Action of Amides Inspired by Gibbilimbol B
Published in ACS omega (05-11-2024)“…The problems with current strategies to control canine visceral Leishmaniasis (CVL), which include the euthanasia of infected animals, and also the toxicity of…”
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Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H 3 and dopamine D 3 receptors
Published in Bioorganic & medicinal chemistry (15-01-2023)“…Multitargeting ligands on enzymes and receptors may generate a profile for a potential treatment of cognitive impairment. Considering this, a set of 21…”
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